Similar articles for PMID: 29699923

Year	Number of Results
1999	1
2002	3
2003	1
2004	1
2005	1
2006	1
2007	5
2008	2
2009	4
2010	13
2011	11
2012	12
2013	14
2014	12
2015	9
2016	8
2017	6
2018	5
2019	6
2020	3
2021	2
2022	1
2024	0

1

Discovery of dimethyl pent-4-ynoic acid derivatives, as potent and orally bioavailable DGAT1 inhibitors that suppress body weight in diet-induced mouse obesity model.

Yu T, Wu C, Shih N, Li Q, Chan C, Pan H, Yao D, Pan Y, Liang W, Shen L, Zhao H, Li J, Chen S. Yu T, et al. Bioorg Med Chem Lett. 2018 Jun 1;28(10):1686-1692. doi: 10.1016/j.bmcl.2018.04.051. Epub 2018 Apr 21. Bioorg Med Chem Lett. 2018. PMID: 29699923

2

Synthesis and evaluation of cyclohexane carboxylic acid head group containing isoxazole and thiazole analogs as DGAT1 inhibitors.

Kandre S, Bhagat PR, Reddy MM, Dalal R, Dixit A, Deshmukh NJ, Anthony J, Bose J, Anupindi R, Sharma R, Gupte A. Kandre S, et al. Eur J Med Chem. 2014 May 22;79:203-15. doi: 10.1016/j.ejmech.2014.03.077. Epub 2014 Mar 28. Eur J Med Chem. 2014. PMID: 24735646

3

Discovery and optimization of adamantane carboxylic acid derivatives as potent diacylglycerol acyltransferase 1 inhibitors for the potential treatment of obesity and diabetes.

Pagire SH, Pagire HS, Lee GB, Han SJ, Kwak HJ, Kim JY, Kim KY, Rhee SD, Ryu JI, Song JS, Bae MA, Park MJ, Kim D, Lee DH, Ahn JH. Pagire SH, et al. Eur J Med Chem. 2015 Aug 28;101:716-35. doi: 10.1016/j.ejmech.2015.06.043. Epub 2015 Jun 27. Eur J Med Chem. 2015. PMID: 26218650

4

A novel coenzyme A:diacylglycerol acyltransferase 1 inhibitor stimulates lipid metabolism in muscle and lowers weight in animal models of obesity.

Yamamoto T, Yamaguchi H, Miki H, Kitamura S, Nakada Y, Aicher TD, Pratt SA, Kato K. Yamamoto T, et al. Eur J Pharmacol. 2011 Jan 15;650(2-3):663-72. doi: 10.1016/j.ejphar.2010.10.040. Epub 2010 Oct 29. Eur J Pharmacol. 2011. PMID: 21034741

5

Pharmacological characterization of [trans-5'-(4-amino-7,7-dimethyl-2-trifluoromethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)-2',3'-dihydrospiro(cyclohexane-1,1'-inden)-4-yl]acetic acid monobenzenesulfonate (JTT-553), a novel acyl CoA:diacylglycerol transferase (DGAT) 1 inhibitor.

Tomimoto D, Okuma C, Ishii Y, Akiyama Y, Ohta T, Kakutani M, Ohkuma Y, Ogawa N. Tomimoto D, et al. Biol Pharm Bull. 2015;38(2):263-9. doi: 10.1248/bpb.b14-00655. Biol Pharm Bull. 2015. PMID: 25747985 Free article.

6

Pharmacological inhibition to examine the role of DGAT1 in dietary lipid absorption in rodents and humans.

Maciejewski BS, LaPerle JL, Chen D, Ghosh A, Zavadoski WJ, McDonald TS, Manion TB, Mather D, Patterson TA, Hanna M, Watkins S, Gibbs EM, Calle RA, Steppan CM. Maciejewski BS, et al. Am J Physiol Gastrointest Liver Physiol. 2013 Jun 1;304(11):G958-69. doi: 10.1152/ajpgi.00384.2012. Epub 2013 Apr 4. Am J Physiol Gastrointest Liver Physiol. 2013. PMID: 23558010 Free article. Clinical Trial.

7

Evaluation of thiazole containing biaryl analogs as diacylglycerol acyltransferase 1 (DGAT1) inhibitors.

Kadam KS, Jadhav RD, Kandre S, Guha T, Reddy MM, Brahma MK, Deshmukh NJ, Dixit A, Doshi L, Srinivasan S, Devle J, Damre A, Nemmani KV, Gupte A, Sharma R. Kadam KS, et al. Eur J Med Chem. 2013 Jul;65:337-47. doi: 10.1016/j.ejmech.2013.05.006. Epub 2013 May 14. Eur J Med Chem. 2013. PMID: 23735282

8

Discovery of novel quinoline carboxylic acid series as DGAT1 inhibitors.

Zhou G, Ting PC, Wishart G, Zorn N, Aslanian RG, Lin M, Smith M, Walker SS, Cook J, Van Heek M, Lachowicz J. Zhou G, et al. Bioorg Med Chem Lett. 2014 Apr 1;24(7):1790-4. doi: 10.1016/j.bmcl.2014.02.028. Epub 2014 Feb 19. Bioorg Med Chem Lett. 2014. PMID: 24618302

9

Coenzyme A: diacylglycerol acyltransferase 1 inhibitor ameliorates obesity, liver steatosis, and lipid metabolism abnormality in KKAy mice fed high-fat or high-carbohydrate diets.

Yamamoto T, Yamaguchi H, Miki H, Shimada M, Nakada Y, Ogino M, Asano K, Aoki K, Tamura N, Masago M, Kato K. Yamamoto T, et al. Eur J Pharmacol. 2010 Aug 25;640(1-3):243-9. doi: 10.1016/j.ejphar.2010.04.050. Epub 2010 May 16. Eur J Pharmacol. 2010. PMID: 20478303

10

Current status of the research and development of diacylglycerol O-acyltransferase 1 (DGAT1) inhibitors.

DeVita RJ, Pinto S. DeVita RJ, et al. J Med Chem. 2013 Dec 27;56(24):9820-5. doi: 10.1021/jm4007033. Epub 2013 Sep 3. J Med Chem. 2013. PMID: 23919406 Review.

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