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PgaB orthologues contain a glycoside hydrolase domain that cleaves deacetylated poly-β(1,6)-N-acetylglucosamine and can disrupt bacterial biofilms.

Little DJ, Pfoh R, Le Mauff F, Bamford NC, Notte C, Baker P, Guragain M, Robinson H, Pier GB, Nitz M, Deora R, Sheppard DC, Howell PL.

PLoS Pathog. 2018 Apr 23;14(4):e1006998. doi: 10.1371/journal.ppat.1006998. eCollection 2018 Apr.


Modification and periplasmic translocation of the biofilm exopolysaccharide poly-β-1,6-N-acetyl-D-glucosamine.

Little DJ, Li G, Ing C, DiFrancesco BR, Bamford NC, Robinson H, Nitz M, Pomès R, Howell PL.

Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):11013-8. doi: 10.1073/pnas.1406388111. Epub 2014 Jul 3.


The structure- and metal-dependent activity of Escherichia coli PgaB provides insight into the partial de-N-acetylation of poly-β-1,6-N-acetyl-D-glucosamine.

Little DJ, Poloczek J, Whitney JC, Robinson H, Nitz M, Howell PL.

J Biol Chem. 2012 Sep 7;287(37):31126-37. doi: 10.1074/jbc.M112.390005. Epub 2012 Jul 18.


The protein BpsB is a poly-β-1,6-N-acetyl-D-glucosamine deacetylase required for biofilm formation in Bordetella bronchiseptica.

Little DJ, Milek S, Bamford NC, Ganguly T, DiFrancesco BR, Nitz M, Deora R, Howell PL.

J Biol Chem. 2015 Sep 11;290(37):22827-40. doi: 10.1074/jbc.M115.672469. Epub 2015 Jul 22.


Synthesis and evaluation of inhibitors of E. coli PgaB, a polysaccharide de-N-acetylase involved in biofilm formation.

Chibba A, Poloczek J, Little DJ, Howell PL, Nitz M.

Org Biomol Chem. 2012 Sep 21;10(35):7103-7. doi: 10.1039/c2ob26105g. Epub 2012 Aug 2.


Roles of pgaABCD genes in synthesis, modification, and export of the Escherichia coli biofilm adhesin poly-beta-1,6-N-acetyl-D-glucosamine.

Itoh Y, Rice JD, Goller C, Pannuri A, Taylor J, Meisner J, Beveridge TJ, Preston JF 3rd, Romeo T.

J Bacteriol. 2008 May;190(10):3670-80. doi: 10.1128/JB.01920-07. Epub 2008 Mar 21.


Structural basis for the De-N-acetylation of Poly-β-1,6-N-acetyl-D-glucosamine in Gram-positive bacteria.

Little DJ, Bamford NC, Pokrovskaya V, Robinson H, Nitz M, Howell PL.

J Biol Chem. 2014 Dec 26;289(52):35907-17. doi: 10.1074/jbc.M114.611400. Epub 2014 Oct 30.


Structural Basis for Translocation of a Biofilm-supporting Exopolysaccharide across the Bacterial Outer Membrane.

Wang Y, Andole Pannuri A, Ni D, Zhou H, Cao X, Lu X, Romeo T, Huang Y.

J Biol Chem. 2016 May 6;291(19):10046-57. doi: 10.1074/jbc.M115.711762. Epub 2016 Mar 8.


The structure of the deacetylase domain of Escherichia coli PgaB, an enzyme required for biofilm formation: a circularly permuted member of the carbohydrate esterase 4 family.

Nishiyama T, Noguchi H, Yoshida H, Park SY, Tame JR.

Acta Crystallogr D Biol Crystallogr. 2013 Jan;69(Pt 1):44-51. doi: 10.1107/S0907444912042059. Epub 2012 Dec 20.


Synthetic {beta}-(1->6)-linked N-acetylated and nonacetylated oligoglucosamines used to produce conjugate vaccines for bacterial pathogens.

Gening ML, Maira-Litrán T, Kropec A, Skurnik D, Grout M, Tsvetkov YE, Nifantiev NE, Pier GB.

Infect Immun. 2010 Feb;78(2):764-72. doi: 10.1128/IAI.01093-09. Epub 2009 Nov 30.


Combining in situ proteolysis and mass spectrometry to crystallize Escherichia coli PgaB.

Little DJ, Whitney JC, Robinson H, Yip P, Nitz M, Howell PL.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Jul 1;68(Pt 7):842-5. doi: 10.1107/S1744309112022075. Epub 2012 Jun 28.


Molecular basis for preferential protective efficacy of antibodies directed to the poorly acetylated form of staphylococcal poly-N-acetyl-beta-(1-6)-glucosamine.

Cerca N, Jefferson KK, Maira-Litrán T, Pier DB, Kelly-Quintos C, Goldmann DA, Azeredo J, Pier GB.

Infect Immun. 2007 Jul;75(7):3406-13. Epub 2007 Apr 30.


Structural basis for antibody targeting of the broadly expressed microbial polysaccharide poly-N-acetylglucosamine.

Soliman C, Walduck AK, Yuriev E, Richards JS, Cywes-Bentley C, Pier GB, Ramsland PA.

J Biol Chem. 2018 Apr 6;293(14):5079-5089. doi: 10.1074/jbc.RA117.001170. Epub 2018 Feb 15.


The diguanylate cyclase YddV controls production of the exopolysaccharide poly-N-acetylglucosamine (PNAG) through regulation of the PNAG biosynthetic pgaABCD operon.

Tagliabue L, Antoniani D, Maciag A, Bocci P, Raffaelli N, Landini P.

Microbiology. 2010 Oct;156(Pt 10):2901-11. doi: 10.1099/mic.0.041350-0. Epub 2010 Jun 24.


Characterization of the poly-β-1,6-N-acetylglucosamine polysaccharide component of Burkholderia biofilms.

Yakandawala N, Gawande PV, LoVetri K, Cardona ST, Romeo T, Nitz M, Madhyastha S.

Appl Environ Microbiol. 2011 Dec;77(23):8303-9. doi: 10.1128/AEM.05814-11. Epub 2011 Oct 7.


The pgaABCD locus of Acinetobacter baumannii encodes the production of poly-beta-1-6-N-acetylglucosamine, which is critical for biofilm formation.

Choi AH, Slamti L, Avci FY, Pier GB, Maira-Litrán T.

J Bacteriol. 2009 Oct;191(19):5953-63. doi: 10.1128/JB.00647-09. Epub 2009 Jul 24.


Genetic dissection of an exogenously induced biofilm in laboratory and clinical isolates of E. coli.

Amini S, Goodarzi H, Tavazoie S.

PLoS Pathog. 2009 May;5(5):e1000432. doi: 10.1371/journal.ppat.1000432. Epub 2009 May 15.


Comparative opsonic and protective activities of Staphylococcus aureus conjugate vaccines containing native or deacetylated Staphylococcal Poly-N-acetyl-beta-(1-6)-glucosamine.

Maira-Litrán T, Kropec A, Goldmann DA, Pier GB.

Infect Immun. 2005 Oct;73(10):6752-62. Erratum in: Infect Immun. 2005 Nov;73(11):7789.


Role of de-N-acetylase PgaB from Aggregatibacter actinomycetemcomitans in exopolysaccharide export in biofilm mode of growth.

Shanmugam M, Oyeniyi AO, Parthiban C, Gujjarlapudi SK, Pier GB, Ramasubbu N.

Mol Oral Microbiol. 2017 Dec;32(6):500-510. doi: 10.1111/omi.12188. Epub 2017 Jul 3.

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