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Items: 1 to 20 of 172

1.

Distinct Stimulatory Mechanisms Regulate the Catalytic Activity of Polycomb Repressive Complex 2.

Lee CH, Holder M, Grau D, Saldaña-Meyer R, Yu JR, Ganai RA, Zhang J, Wang M, LeRoy G, Dobenecker MW, Reinberg D, Armache KJ.

Mol Cell. 2018 May 3;70(3):435-448.e5. doi: 10.1016/j.molcel.2018.03.019. Epub 2018 Apr 19.

2.

EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency.

Shen X, Liu Y, Hsu YJ, Fujiwara Y, Kim J, Mao X, Yuan GC, Orkin SH.

Mol Cell. 2008 Nov 21;32(4):491-502. doi: 10.1016/j.molcel.2008.10.016.

3.

Dissecting the role of H3K27 acetylation and methylation in PRC2 mediated control of cellular identity.

Lavarone E, Barbieri CM, Pasini D.

Nat Commun. 2019 Apr 11;10(1):1679. doi: 10.1038/s41467-019-09624-w.

4.

EZH2 variants differentially regulate polycomb repressive complex 2 in histone methylation and cell differentiation.

Mu W, Starmer J, Yee D, Magnuson T.

Epigenetics Chromatin. 2018 Dec 6;11(1):71. doi: 10.1186/s13072-018-0242-9.

5.

The H3K36me2 Methyltransferase Nsd1 Demarcates PRC2-Mediated H3K27me2 and H3K27me3 Domains in Embryonic Stem Cells.

Streubel G, Watson A, Jammula SG, Scelfo A, Fitzpatrick DJ, Oliviero G, McCole R, Conway E, Glancy E, Negri GL, Dillon E, Wynne K, Pasini D, Krogan NJ, Bracken AP, Cagney G.

Mol Cell. 2018 Apr 19;70(2):371-379.e5. doi: 10.1016/j.molcel.2018.02.027. Epub 2018 Mar 29.

6.

EZH1 in germ cells safeguards the function of PRC2 during spermatogenesis.

Mu W, Starmer J, Shibata Y, Yee D, Magnuson T.

Dev Biol. 2017 Apr 15;424(2):198-207. doi: 10.1016/j.ydbio.2017.02.017. Epub 2017 Feb 28.

7.

Nucleosome-binding activities within JARID2 and EZH1 regulate the function of PRC2 on chromatin.

Son J, Shen SS, Margueron R, Reinberg D.

Genes Dev. 2013 Dec 15;27(24):2663-77. doi: 10.1101/gad.225888.113. Erratum in: Genes Dev. 2014 Apr 15;28(8):921.

8.

Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms.

Margueron R, Li G, Sarma K, Blais A, Zavadil J, Woodcock CL, Dynlacht BD, Reinberg D.

Mol Cell. 2008 Nov 21;32(4):503-18. doi: 10.1016/j.molcel.2008.11.004.

9.

Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas.

Sneeringer CJ, Scott MP, Kuntz KW, Knutson SK, Pollock RM, Richon VM, Copeland RA.

Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):20980-5. doi: 10.1073/pnas.1012525107. Epub 2010 Nov 15.

10.

Molecular Mechanisms Directing PRC2 Recruitment and H3K27 Methylation.

Laugesen A, Højfeldt JW, Helin K.

Mol Cell. 2019 Apr 4;74(1):8-18. doi: 10.1016/j.molcel.2019.03.011. Review.

PMID:
30951652
11.

A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities.

Conway E, Jerman E, Healy E, Ito S, Holoch D, Oliviero G, Deevy O, Glancy E, Fitzpatrick DJ, Mucha M, Watson A, Rice AM, Chammas P, Huang C, Pratt-Kelly I, Koseki Y, Nakayama M, Ishikura T, Streubel G, Wynne K, Hokamp K, McLysaght A, Ciferri C, Di Croce L, Cagney G, Margueron R, Koseki H, Bracken AP.

Mol Cell. 2018 May 3;70(3):408-421.e8. doi: 10.1016/j.molcel.2018.03.005. Epub 2018 Apr 5.

12.

Ezh1 and Ezh2 differentially regulate PSD-95 gene transcription in developing hippocampal neurons.

Henriquez B, Bustos FJ, Aguilar R, Becerra A, Simon F, Montecino M, van Zundert B.

Mol Cell Neurosci. 2013 Nov;57:130-43. doi: 10.1016/j.mcn.2013.07.012. Epub 2013 Aug 8.

PMID:
23932971
13.

Jarid2 Methylation via the PRC2 Complex Regulates H3K27me3 Deposition during Cell Differentiation.

Sanulli S, Justin N, Teissandier A, Ancelin K, Portoso M, Caron M, Michaud A, Lombard B, da Rocha ST, Offer J, Loew D, Servant N, Wassef M, Burlina F, Gamblin SJ, Heard E, Margueron R.

Mol Cell. 2015 Mar 5;57(5):769-783. doi: 10.1016/j.molcel.2014.12.020. Epub 2015 Jan 22.

14.

Functional analysis of AEBP2, a PRC2 Polycomb protein, reveals a Trithorax phenotype in embryonic development and in ESCs.

Grijzenhout A, Godwin J, Koseki H, Gdula MR, Szumska D, McGouran JF, Bhattacharya S, Kessler BM, Brockdorff N, Cooper S.

Development. 2016 Aug 1;143(15):2716-23. doi: 10.1242/dev.123935. Epub 2016 Jun 17.

15.

The histone H3K27 methylation mark regulates intestinal epithelial cell density-dependent proliferation and the inflammatory response.

Turgeon N, Blais M, Delabre JF, Asselin C.

J Cell Biochem. 2013 May;114(5):1203-15. doi: 10.1002/jcb.24463.

16.

Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.

Oliviero G, Brien GL, Waston A, Streubel G, Jerman E, Andrews D, Doyle B, Munawar N, Wynne K, Crean J, Bracken AP, Cagney G.

Mol Cell Proteomics. 2016 Nov;15(11):3450-3460. Epub 2016 Sep 15.

17.

Inner workings and regulatory inputs that control Polycomb repressive complex 2.

O'Meara MM, Simon JA.

Chromosoma. 2012 Jun;121(3):221-34. doi: 10.1007/s00412-012-0361-1. Epub 2012 Feb 19. Review.

18.

Accurate H3K27 methylation can be established de novo by SUZ12-directed PRC2.

Højfeldt JW, Laugesen A, Willumsen BM, Damhofer H, Hedehus L, Tvardovskiy A, Mohammad F, Jensen ON, Helin K.

Nat Struct Mol Biol. 2018 Mar;25(3):225-232. doi: 10.1038/s41594-018-0036-6. Epub 2018 Feb 26.

19.

Structure-Activity Relationship Studies for Enhancer of Zeste Homologue 2 (EZH2) and Enhancer of Zeste Homologue 1 (EZH1) Inhibitors.

Yang X, Li F, Konze KD, Meslamani J, Ma A, Brown PJ, Zhou MM, Arrowsmith CH, Kaniskan HÜ, Vedadi M, Jin J.

J Med Chem. 2016 Aug 25;59(16):7617-33. doi: 10.1021/acs.jmedchem.6b00855. Epub 2016 Aug 11.

20.

CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cells.

Wei Y, Chen YH, Li LY, Lang J, Yeh SP, Shi B, Yang CC, Yang JY, Lin CY, Lai CC, Hung MC.

Nat Cell Biol. 2011 Jan;13(1):87-94. doi: 10.1038/ncb2139. Epub 2010 Dec 5.

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