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Items: 1 to 20 of 82

1.

Role and inhibition of GLI1 protein in cancer.

Mastrangelo E, Milani M.

Lung Cancer (Auckl). 2018 Mar 27;9:35-43. doi: 10.2147/LCTT.S124483. eCollection 2018. Review.

2.

Gli1-Mediated Regulation of Sox2 Facilitates Self-Renewal of Stem-Like Cells and Confers Resistance to EGFR Inhibitors in Non-Small Cell Lung Cancer.

Bora-Singhal N, Perumal D, Nguyen J, Chellappan S.

Neoplasia. 2015 Jul;17(7):538-51. doi: 10.1016/j.neo.2015.07.001.

3.

CK2α, over-expressed in human malignant pleural mesothelioma, regulates the Hedgehog signaling pathway in mesothelioma cells.

Zhang S, Yang YL, Wang Y, You B, Dai Y, Chan G, Hsieh D, Kim IJ, Fang LT, Au A, Stoppler HJ, Xu Z, Jablons DM, You L.

J Exp Clin Cancer Res. 2014 Nov 25;33:93. doi: 10.1186/s13046-014-0093-6.

4.

Inhibition of p70S6K2 down-regulates Hedgehog/GLI pathway in non-small cell lung cancer cell lines.

Mizuarai S, Kawagishi A, Kotani H.

Mol Cancer. 2009 Jul 6;8:44. doi: 10.1186/1476-4598-8-44.

5.

Inhibition of Gli1-mediated prostate cancer cell proliferation by inhibiting the mTOR/S6K1 signaling pathway.

Yang H, Hu L, Liu Z, Qin Y, Li R, Zhang G, Zhao B, Bi C, Lei Y, Bai Y.

Oncol Lett. 2017 Dec;14(6):7970-7976. doi: 10.3892/ol.2017.7254. Epub 2017 Oct 23.

6.

Inhibition of CK2α down-regulates Hedgehog/Gli signaling leading to a reduction of a stem-like side population in human lung cancer cells.

Zhang S, Wang Y, Mao JH, Hsieh D, Kim IJ, Hu LM, Xu Z, Long H, Jablons DM, You L.

PLoS One. 2012;7(6):e38996. doi: 10.1371/journal.pone.0038996. Epub 2012 Jun 29.

7.

Synergism between Hedgehog-GLI and EGFR signaling in Hedgehog-responsive human medulloblastoma cells induces downregulation of canonical Hedgehog-target genes and stabilized expression of GLI1.

Götschel F, Berg D, Gruber W, Bender C, Eberl M, Friedel M, Sonntag J, Rüngeler E, Hache H, Wierling C, Nietfeld W, Lehrach H, Frischauf A, Schwartz-Albiez R, Aberger F, Korf U.

PLoS One. 2013 Jun 10;8(6):e65403. doi: 10.1371/journal.pone.0065403. Print 2013.

8.

RNA editing of the GLI1 transcription factor modulates the output of Hedgehog signaling.

Shimokawa T, Rahman MF, Tostar U, Sonkoly E, Ståhle M, Pivarcsi A, Palaniswamy R, Zaphiropoulos PG.

RNA Biol. 2013 Feb;10(2):321-33. doi: 10.4161/rna.23343. Epub 2013 Jan 16.

9.

The GLI genes as the molecular switch in disrupting Hedgehog signaling in colon cancer.

Mazumdar T, DeVecchio J, Agyeman A, Shi T, Houghton JA.

Oncotarget. 2011 Aug;2(8):638-45.

10.

Gli1 mediates lung cancer cell proliferation and Sonic Hedgehog-dependent mesenchymal cell activation.

Bermudez O, Hennen E, Koch I, Lindner M, Eickelberg O.

PLoS One. 2013 May 7;8(5):e63226. doi: 10.1371/journal.pone.0063226. Print 2013.

11.

Menin directly represses Gli1 expression independent of canonical Hedgehog signaling.

Gurung B, Feng Z, Hua X.

Mol Cancer Res. 2013 Oct;11(10):1215-22. doi: 10.1158/1541-7786.MCR-13-0170. Epub 2013 Aug 8.

12.

Hedgehog signaling in small-cell lung cancer: frequent in vivo but a rare event in vitro.

Vestergaard J, Pedersen MW, Pedersen N, Ensinger C, Tümer Z, Tommerup N, Poulsen HS, Larsen LA.

Lung Cancer. 2006 Jun;52(3):281-90. Epub 2006 Apr 17.

PMID:
16616798
13.

Gli1 protein regulates the S-phase checkpoint in tumor cells via Bid protein, and its inhibition sensitizes to DNA topoisomerase 1 inhibitors.

Tripathi K, Mani C, Barnett R, Nalluri S, Bachaboina L, Rocconi RP, Athar M, Owen LB, Palle K.

J Biol Chem. 2014 Nov 7;289(45):31513-25. doi: 10.1074/jbc.M114.606483. Epub 2014 Sep 24.

14.

Sonic hedgehog signaling pathway is activated in ALK-positive anaplastic large cell lymphoma.

Singh RR, Cho-Vega JH, Davuluri Y, Ma S, Kasbidi F, Milito C, Lennon PA, Drakos E, Medeiros LJ, Luthra R, Vega F.

Cancer Res. 2009 Mar 15;69(6):2550-8. doi: 10.1158/0008-5472.CAN-08-1808. Epub 2009 Feb 24.

15.

Protein kinase Cdelta negatively regulates hedgehog signaling by inhibition of Gli1 activity.

Cai Q, Li J, Gao T, Xie J, Evers BM.

J Biol Chem. 2009 Jan 23;284(4):2150-8. doi: 10.1074/jbc.M803235200. Epub 2008 Nov 17.

16.

In vitro and in vivo inhibition of breast cancer cell growth by targeting the Hedgehog/GLI pathway with SMO (GDC-0449) or GLI (GANT-61) inhibitors.

Benvenuto M, Masuelli L, De Smaele E, Fantini M, Mattera R, Cucchi D, Bonanno E, Di Stefano E, Frajese GV, Orlandi A, Screpanti I, Gulino A, Modesti A, Bei R.

Oncotarget. 2016 Feb 23;7(8):9250-70. doi: 10.18632/oncotarget.7062.

17.

Gli1 transcriptional activity is negatively regulated by AKT2 in neuroblastoma.

Paul P, Volny N, Lee S, Qiao J, Chung DH.

Oncotarget. 2013 Aug;4(8):1149-57.

18.

WIP1 phosphatase modulates the Hedgehog signaling by enhancing GLI1 function.

Pandolfi S, Montagnani V, Penachioni JY, Vinci MC, Olivito B, Borgognoni L, Stecca B.

Oncogene. 2013 Oct;32(40):4737-47. doi: 10.1038/onc.2012.502. Epub 2012 Nov 12.

PMID:
23146903
19.

Aberrant activation of hedgehog signaling pathway contributes to endometrial carcinogenesis through beta-catenin.

Liao X, Siu MK, Au CW, Chan QK, Chan HY, Wong ES, Ip PP, Ngan HY, Cheung AN.

Mod Pathol. 2009 Jun;22(6):839-47. doi: 10.1038/modpathol.2009.45. Epub 2009 Mar 27.

20.

Combinatorial chemoprevention reveals a novel smoothened-independent role of GLI1 in esophageal carcinogenesis.

Rizvi S, Demars CJ, Comba A, Gainullin VG, Rizvi Z, Almada LL, Wang K, Lomberk G, Fernández-Zapico ME, Buttar NS.

Cancer Res. 2010 Sep 1;70(17):6787-96. doi: 10.1158/0008-5472.CAN-10-0197. Epub 2010 Jul 20.

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