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Items: 1 to 20 of 102


Hypomethylation of GRHL3 gene is associated with the occurrence of neural tube defects.

Tian T, Wang L, Shen Y, Zhang B, Finnell RH, Ren A.

Epigenomics. 2018 Jul;10(7):891-901. doi: 10.2217/epi-2018-0016. Epub 2018 Mar 28.


Neural tube closure depends on expression of Grainyhead-like 3 in multiple tissues.

De Castro SCP, Hirst CS, Savery D, Rolo A, Lickert H, Andersen B, Copp AJ, Greene NDE.

Dev Biol. 2018 Mar 15;435(2):130-137. doi: 10.1016/j.ydbio.2018.01.016. Epub 2018 Feb 2.


DNA methylation analysis of Homeobox genes implicates HOXB7 hypomethylation as risk factor for neural tube defects.

Rochtus A, Izzi B, Vangeel E, Louwette S, Wittevrongel C, Lambrechts D, Moreau Y, Winand R, Verpoorten C, Jansen K, Van Geet C, Freson K.

Epigenetics. 2015;10(1):92-101. doi: 10.1080/15592294.2014.998531. Epub 2015 Jan 29.


Aberrant methylation of Pax3 gene and neural tube defects in association with exposure to polycyclic aromatic hydrocarbons.

Lin S, Ren A, Wang L, Santos C, Huang Y, Jin L, Li Z, Greene NDE.

Clin Epigenetics. 2019 Jan 21;11(1):13. doi: 10.1186/s13148-019-0611-7.


Fetal DNA hypermethylation in tight junction pathway is associated with neural tube defects: A genome-wide DNA methylation analysis.

Wang L, Lin S, Zhang J, Tian T, Jin L, Ren A.

Epigenetics. 2017 Feb;12(2):157-165. doi: 10.1080/15592294.2016.1277298. Epub 2017 Jan 6.


Overexpression of Grainyhead-like 3 causes spina bifida and interacts genetically with mutant alleles of Grhl2 and Vangl2 in mice.

De Castro SCP, Gustavsson P, Marshall AR, Gordon WM, Galea G, Nikolopoulou E, Savery D, Rolo A, Stanier P, Andersen B, Copp AJ, Greene NDE.

Hum Mol Genet. 2018 Dec 15;27(24):4218-4230. doi: 10.1093/hmg/ddy313.


The green tea polyphenol EGCG alleviates maternal diabetes-induced neural tube defects by inhibiting DNA hypermethylation.

Zhong J, Xu C, Reece EA, Yang P.

Am J Obstet Gynecol. 2016 Sep;215(3):368.e1-368.e10. doi: 10.1016/j.ajog.2016.03.009. Epub 2016 Mar 12.


TRIM4 is associated with neural tube defects based on genome-wide DNA methylation analysis.

Zhang H, Guo Y, Gu H, Wei X, Ma W, Liu D, Yu K, Luo W, Ma L, Liu Y, Xue J, Huang J, Wang Y, Jia S, Dong N, Wang H, Yuan Z.

Clin Epigenetics. 2019 Feb 1;11(1):17. doi: 10.1186/s13148-018-0603-z.


Global DNA hypomethylation is associated with NTD-affected pregnancy: A case-control study.

Chen X, Guo J, Lei Y, Zou J, Lu X, Bao Y, Wu L, Wu J, Zheng X, Shen Y, Wu BL, Zhang T.

Birth Defects Res A Clin Mol Teratol. 2010 Jul;88(7):575-81. doi: 10.1002/bdra.20670.


Methylome analysis for spina bifida shows SOX18 hypomethylation as a risk factor with evidence for a complex (epi)genetic interplay to affect neural tube development.

Rochtus A, Winand R, Laenen G, Vangeel E, Izzi B, Wittevrongel C, Moreau Y, Verpoorten C, Jansen K, Van Geet C, Freson K.

Clin Epigenetics. 2016 Oct 13;8:108. eCollection 2016.


Rare deleterious variants in GRHL3 are associated with human spina bifida.

Lemay P, De Marco P, Emond A, Spiegelman D, Dionne-Laporte A, Laurent S, Merello E, Accogli A, Rouleau GA, Capra V, Kibar Z.

Hum Mutat. 2017 Jun;38(6):716-724. doi: 10.1002/humu.23214. Epub 2017 Mar 24.


Grainyhead genes and mammalian neural tube closure.

Gustavsson P, Copp AJ, Greene ND.

Birth Defects Res A Clin Mol Teratol. 2008 Oct;82(10):728-35. doi: 10.1002/bdra.20494. Review.


Mis-expression of grainyhead-like transcription factors in zebrafish leads to defects in enveloping layer (EVL) integrity, cellular morphogenesis and axial extension.

Miles LB, Darido C, Kaslin J, Heath JK, Jane SM, Dworkin S.

Sci Rep. 2017 Dec 14;7(1):17607. doi: 10.1038/s41598-017-17898-7.


Tissue-Specific Methylation of Long Interspersed Nucleotide Element-1 of Homo Sapiens (L1Hs) During Human Embryogenesis and Roles in Neural Tube Defects.

Wang L, Chang S, Guan J, Shangguan S, Lu X, Wang Z, Wu L, Zou J, Zhao H, Bao Y, Qiu Z, Niu B, Zhang T.

Curr Mol Med. 2015;15(5):497-507.


Folate deficiency disturbs hsa-let-7 g level through methylation regulation in neural tube defects.

Wang L, Shangguan S, Xin Y, Chang S, Wang Z, Lu X, Wu L, Niu B, Zhang T.

J Cell Mol Med. 2017 Dec;21(12):3244-3253. doi: 10.1111/jcmm.13228. Epub 2017 Jun 19.


Increased expression of Grainyhead-like-3 rescues spina bifida in a folate-resistant mouse model.

Gustavsson P, Greene ND, Lad D, Pauws E, de Castro SC, Stanier P, Copp AJ.

Hum Mol Genet. 2007 Nov 1;16(21):2640-6. Epub 2007 Aug 24.


DNA methylation aberrations rather than polymorphisms of FZD3 gene increase the risk of spina bifida in a high-risk region for neural tube defects.

Shangguan S, Wang L, Chang S, Lu X, Wang Z, Wu L, Wang J, Wang X, Guan Z, Bao Y, Zhao H, Zou J, Niu B, Zhang T.

Birth Defects Res A Clin Mol Teratol. 2015 Jan;103(1):37-44. doi: 10.1002/bdra.23285. Epub 2014 Aug 18.


Relationship of Methylation within Upper Stream Region of Transcription Starts Site of HOXA5 Gene with Neural Tube Defects.

Zhang J, Tian T, Yi Q, Wang LL, Ren AG.

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2017 Dec 20;39(6):785-791. doi: 10.3881/j.issn.1000-503X.2017.06.009.


Altered methylation of IGF2 DMR0 is associated with neural tube defects.

Wu L, Wang L, Shangguan S, Chang S, Wang Z, Lu X, Zhang Q, Wang J, Zhao H, Wang F, Guo J, Niu B, Guo J, Zhang T.

Mol Cell Biochem. 2013 Aug;380(1-2):33-42. doi: 10.1007/s11010-013-1655-1. Epub 2013 May 21.


Neural tube defects induced by folate deficiency in mutant curly tail (Grhl3) embryos are associated with alteration in folate one-carbon metabolism but are unlikely to result from diminished methylation.

De Castro SC, Leung KY, Savery D, Burren K, Rozen R, Copp AJ, Greene ND.

Birth Defects Res A Clin Mol Teratol. 2010 Aug;88(8):612-8. doi: 10.1002/bdra.20690.

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