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Mediterranean Diet, Glucose Homeostasis, and Inflammasome Genetic Variants: The CORDIOPREV Study.

Roncero-Ramos I, Rangel-Zuñiga OA, Lopez-Moreno J, Alcala-Diaz JF, Perez-Martinez P, Jimenez-Lucena R, Castaño JP, Roche HM, Delgado-Lista J, Ordovas JM, Camargo A, Lopez-Miranda J.

Mol Nutr Food Res. 2018 May;62(9):e1700960. doi: 10.1002/mnfr.201700960. Epub 2018 Apr 20.


Telomerase RNA Component Genetic Variants Interact With the Mediterranean Diet Modifying the Inflammatory Status and its Relationship With Aging: CORDIOPREV Study.

Gomez-Delgado F, Delgado-Lista J, Lopez-Moreno J, Rangel-Zuñiga OA, Alcala-Diaz JF, Leon-Acuña A, Corina A, Yubero-Serrano E, Torres-Peña JD, Camargo A, Garcia-Rios A, Caballero J, Castaño J, Ordovas JM, Lopez-Miranda J, Perez-Martinez P.

J Gerontol A Biol Sci Med Sci. 2018 Mar 2;73(3):327-332. doi: 10.1093/gerona/glw194.


Variants of NLRP3 gene are associated with insulin resistance in Chinese Han population with type-2 diabetes.

Zheng Y, Zhang D, Zhang L, Fu M, Zeng Y, Russell R.

Gene. 2013 Nov 1;530(1):151-4. doi: 10.1016/j.gene.2013.07.082. Epub 2013 Aug 22.


A novel mechanism of diabetic vascular endothelial dysfunction: Hypoadiponectinemia-induced NLRP3 inflammasome activation.

Zhang J, Xia L, Zhang F, Zhu D, Xin C, Wang H, Zhang F, Guo X, Lee Y, Zhang L, Wang S, Guo X, Huang C, Gao F, Liu Y, Tao L.

Biochim Biophys Acta Mol Basis Dis. 2017 Jun;1863(6):1556-1567. doi: 10.1016/j.bbadis.2017.02.012. Epub 2017 Feb 13.


NLRP3 gene silencing ameliorates diabetic cardiomyopathy in a type 2 diabetes rat model.

Luo B, Li B, Wang W, Liu X, Xia Y, Zhang C, Zhang M, Zhang Y, An F.

PLoS One. 2014 Aug 19;9(8):e104771. doi: 10.1371/journal.pone.0104771. eCollection 2014.


The genetic polymorphism and expression profiles of NLRP3 inflammasome in patients with chronic myeloid leukemia.

Zhang A, Yu J, Yan S, Zhao X, Chen C, Zhou Y, Zhao X, Hua M, Wang R, Zhang C, Zhong C, He N, Ji C, Ma D.

Hum Immunol. 2018 Jan;79(1):57-62. doi: 10.1016/j.humimm.2017.10.013. Epub 2017 Oct 31.


Ablation of Neuropilin 1 in Myeloid Cells Exacerbates High-Fat Diet-Induced Insulin Resistance Through Nlrp3 Inflammasome In Vivo.

Dai X, Okon I, Liu Z, Bedarida T, Wang Q, Ramprasath T, Zhang M, Song P, Zou MH.

Diabetes. 2017 Sep;66(9):2424-2435. doi: 10.2337/db17-0132. Epub 2017 Jun 28.


Study of the NLRP3 inflammasome component genes and downstream cytokines in patients with type 2 diabetes mellitus with carotid atherosclerosis.

Lee J, Wan J, Lee L, Peng C, Xie H, Lee C.

Lipids Health Dis. 2017 Nov 18;16(1):217. doi: 10.1186/s12944-017-0595-2.


Beneficial effect of CLOCK gene polymorphism rs1801260 in combination with low-fat diet on insulin metabolism in the patients with metabolic syndrome.

Garcia-Rios A, Gomez-Delgado FJ, Garaulet M, Alcala-Diaz JF, Delgado-Lista FJ, Marin C, Rangel-Zuñiga OA, Rodriguez-Cantalejo F, Gomez-Luna P, Ordovas JM, Perez-Jimenez F, Lopez-Miranda J, Perez-Martinez P.

Chronobiol Int. 2014 Apr;31(3):401-8. doi: 10.3109/07420528.2013.864300. Epub 2013 Dec 11.


The purinergic 2X7 receptor participates in renal inflammation and injury induced by high-fat diet: possible role of NLRP3 inflammasome activation.

Solini A, Menini S, Rossi C, Ricci C, Santini E, Blasetti Fantauzzi C, Iacobini C, Pugliese G.

J Pathol. 2013 Nov;231(3):342-53. doi: 10.1002/path.4237. Epub 2013 Sep 3.


Combined SGLT2 and DPP4 Inhibition Reduces the Activation of the Nlrp3/ASC Inflammasome and Attenuates the Development of Diabetic Nephropathy in Mice with Type 2 Diabetes.

Birnbaum Y, Bajaj M, Yang HC, Ye Y.

Cardiovasc Drugs Ther. 2018 Apr;32(2):135-145. doi: 10.1007/s10557-018-6778-x.


Banxia-houpu decoction restores glucose intolerance in CUMS rats through improvement of insulin signaling and suppression of NLRP3 inflammasome activation in liver and brain.

Jia KK, Zheng YJ, Zhang YX, Liu JH, Jiao RQ, Pan Y, Kong LD.

J Ethnopharmacol. 2017 Sep 14;209:219-229. doi: 10.1016/j.jep.2017.08.004. Epub 2017 Aug 4.


Contribution of redox-dependent activation of endothelial Nlrp3 inflammasomes to hyperglycemia-induced endothelial dysfunction.

Chen Y, Wang L, Pitzer AL, Li X, Li PL, Zhang Y.

J Mol Med (Berl). 2016 Dec;94(12):1335-1347. Epub 2016 Oct 25.


A casein hydrolysate protects mice against high fat diet induced hyperglycemia by attenuating NLRP3 inflammasome-mediated inflammation and improving insulin signaling.

Healy NP, Kirwan AM, McArdle MA, Holohan K, Nongonierma AB, Keane D, Kelly S, Celkova L, Lyons CL, McGillicuddy FC, Finucane OM, Murray BA, Kelly PM, Brennan L, FitzGerald RJ, Roche HM.

Mol Nutr Food Res. 2016 Nov;60(11):2421-2432. doi: 10.1002/mnfr.201501054. Epub 2016 Sep 8.


Suppression of NLRP3 inflammasome by γ-tocotrienol ameliorates type 2 diabetes.

Kim Y, Wang W, Okla M, Kang I, Moreau R, Chung S.

J Lipid Res. 2016 Jan;57(1):66-76. doi: 10.1194/jlr.M062828. Epub 2015 Dec 1.


Lipid environment induces ER stress, TXNIP expression and inflammation in immune cells of individuals with type 2 diabetes.

Szpigel A, Hainault I, Carlier A, Venteclef N, Batto AF, Hajduch E, Bernard C, Ktorza A, Gautier JF, Ferré P, Bourron O, Foufelle F.

Diabetologia. 2018 Feb;61(2):399-412. doi: 10.1007/s00125-017-4462-5. Epub 2017 Oct 7.


Berberine inhibits palmitate-induced NLRP3 inflammasome activation by triggering autophagy in macrophages: A new mechanism linking berberine to insulin resistance improvement.

Zhou H, Feng L, Xu F, Sun Y, Ma Y, Zhang X, Liu H, Xu G, Wu X, Shen Y, Sun Y, Wu X, Xu Q.

Biomed Pharmacother. 2017 May;89:864-874. doi: 10.1016/j.biopha.2017.03.003. Epub 2017 Mar 6.


Instigation of endothelial Nlrp3 inflammasome by adipokine visfatin promotes inter-endothelial junction disruption: role of HMGB1.

Chen Y, Pitzer AL, Li X, Li PL, Wang L, Zhang Y.

J Cell Mol Med. 2015 Dec;19(12):2715-27. doi: 10.1111/jcmm.12657. Epub 2015 Aug 20.


Adipocyte-derived Lysophosphatidylcholine Activates Adipocyte and Adipose Tissue Macrophage Nod-Like Receptor Protein 3 Inflammasomes Mediating Homocysteine-Induced Insulin Resistance.

Zhang SY, Dong YQ, Wang P, Zhang X, Yan Y, Sun L, Liu B, Zhang D, Zhang H, Liu H, Kong W, Hu G, Shah YM, Gonzalez FJ, Wang X, Jiang C.

EBioMedicine. 2018 May;31:202-216. doi: 10.1016/j.ebiom.2018.04.022. Epub 2018 Apr 27.

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