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Items: 1 to 20 of 117

1.

The Colibactin Genotoxin Generates DNA Interstrand Cross-Links in Infected Cells.

Bossuet-Greif N, Vignard J, Taieb F, Mirey G, Dubois D, Petit C, Oswald E, Nougayrède JP.

MBio. 2018 Mar 20;9(2). pii: e02393-17. doi: 10.1128/mBio.02393-17.

2.

Escherichia coli ClbS is a colibactin resistance protein.

Bossuet-Greif N, Dubois D, Petit C, Tronnet S, Martin P, Bonnet R, Oswald E, Nougayrède JP.

Mol Microbiol. 2016 Mar;99(5):897-908. doi: 10.1111/mmi.13272. Epub 2015 Dec 1.

3.

Model Colibactins Exhibit Human Cell Genotoxicity in the Absence of Host Bacteria.

Shine EE, Xue M, Patel JR, Healy AR, Surovtseva YV, Herzon SB, Crawford JM.

ACS Chem Biol. 2018 Dec 21;13(12):3286-3293. doi: 10.1021/acschembio.8b00714. Epub 2018 Nov 20.

PMID:
30403848
4.

ClbS Is a Cyclopropane Hydrolase That Confers Colibactin Resistance.

Tripathi P, Shine EE, Healy AR, Kim CS, Herzon SB, Bruner SD, Crawford JM.

J Am Chem Soc. 2017 Dec 13;139(49):17719-17722. doi: 10.1021/jacs.7b09971. Epub 2017 Nov 28.

5.

A Mechanistic Model for Colibactin-Induced Genotoxicity.

Healy AR, Nikolayevskiy H, Patel JR, Crawford JM, Herzon SB.

J Am Chem Soc. 2016 Dec 7;138(48):15563-15570. Epub 2016 Nov 28.

6.

The Bacterial Stress-Responsive Hsp90 Chaperone (HtpG) Is Required for the Production of the Genotoxin Colibactin and the Siderophore Yersiniabactin in Escherichia coli.

Garcie C, Tronnet S, Garénaux A, McCarthy AJ, Brachmann AO, Pénary M, Houle S, Nougayrède JP, Piel J, Taylor PW, Dozois CM, Genevaux P, Oswald E, Martin P.

J Infect Dis. 2016 Sep 15;214(6):916-24. doi: 10.1093/infdis/jiw294. Epub 2016 Jul 13.

PMID:
27412582
7.

Gut symbionts from distinct hosts exhibit genotoxic activity via divergent colibactin biosynthesis pathways.

Engel P, Vizcaino MI, Crawford JM.

Appl Environ Microbiol. 2015 Feb;81(4):1502-12.

8.

Domain-Targeted Metabolomics Delineates the Heterocycle Assembly Steps of Colibactin Biosynthesis.

Trautman EP, Healy AR, Shine EE, Herzon SB, Crawford JM.

J Am Chem Soc. 2017 Mar 22;139(11):4195-4201. doi: 10.1021/jacs.7b00659. Epub 2017 Mar 10.

9.

The bacterial genotoxin colibactin promotes colon tumor growth by modifying the tumor microenvironment.

Dalmasso G, Cougnoux A, Delmas J, Darfeuille-Michaud A, Bonnet R.

Gut Microbes. 2014;5(5):675-80. doi: 10.4161/19490976.2014.969989.

10.

Genetic diversity, phylogroup distribution and virulence gene profile of pks positive Escherichia coli colonizing human intestinal polyps.

Sarshar M, Scribano D, Marazzato M, Ambrosi C, Aprea MR, Aleandri M, Pronio A, Longhi C, Nicoletti M, Zagaglia C, Palamara AT, Conte MP.

Microb Pathog. 2017 Nov;112:274-278. doi: 10.1016/j.micpath.2017.10.009. Epub 2017 Oct 5.

PMID:
28987619
11.

Small-molecule inhibitors prevent the genotoxic and protumoural effects induced by colibactin-producing bacteria.

Cougnoux A, Delmas J, Gibold L, Faïs T, Romagnoli C, Robin F, Cuevas-Ramos G, Oswald E, Darfeuille-Michaud A, Prati F, Dalmasso G, Bonnet R.

Gut. 2016 Feb;65(2):278-85. doi: 10.1136/gutjnl-2014-307241. Epub 2015 Jan 14.

PMID:
25588406
12.

An adherent mucus layer attenuates the genotoxic effect of colibactin.

Reuter C, Alzheimer M, Walles H, Oelschlaeger TA.

Cell Microbiol. 2018 Feb;20(2). doi: 10.1111/cmi.12812. Epub 2017 Dec 5.

PMID:
29156489
13.

Molecular Basis of Gut Microbiome-Associated Colorectal Cancer: A Synthetic Perspective.

Healy AR, Herzon SB.

J Am Chem Soc. 2017 Oct 25;139(42):14817-14824. doi: 10.1021/jacs.7b07807. Epub 2017 Oct 12. Review.

PMID:
28949546
14.

Convergent and Modular Synthesis of Candidate Precolibactins. Structural Revision of Precolibactin A.

Healy AR, Vizcaino MI, Crawford JM, Herzon SB.

J Am Chem Soc. 2016 Apr 27;138(16):5426-32. doi: 10.1021/jacs.6b02276. Epub 2016 Apr 12.

15.

Colibactin: More Than a New Bacterial Toxin.

Faïs T, Delmas J, Barnich N, Bonnet R, Dalmasso G.

Toxins (Basel). 2018 Apr 10;10(4). pii: E151. doi: 10.3390/toxins10040151. Review.

16.

MATE transport of the E. coli-derived genotoxin colibactin.

Mousa JJ, Yang Y, Tomkovich S, Shima A, Newsome RC, Tripathi P, Oswald E, Bruner SD, Jobin C.

Nat Microbiol. 2016 Jan 11;1:15009. doi: 10.1038/nmicrobiol.2015.9.

17.

Characterization of Polyketide Synthase Machinery from the pks Island Facilitates Isolation of a Candidate Precolibactin.

Zha L, Wilson MR, Brotherton CA, Balskus EP.

ACS Chem Biol. 2016 May 20;11(5):1287-95. doi: 10.1021/acschembio.6b00014. Epub 2016 Mar 1.

PMID:
26890481
18.

The Enterobacterial Genotoxins: Cytolethal Distending Toxin and Colibactin.

Taieb F, Petit C, Nougayrède JP, Oswald E.

EcoSal Plus. 2016 Jul;7(1). doi: 10.1128/ecosalplus.ESP-0008-2016. Review.

PMID:
27419387
19.

The Genotoxin Colibactin Is a Determinant of Virulence in Escherichia coli K1 Experimental Neonatal Systemic Infection.

McCarthy AJ, Martin P, Cloup E, Stabler RA, Oswald E, Taylor PW.

Infect Immun. 2015 Sep;83(9):3704-11. doi: 10.1128/IAI.00716-15. Epub 2015 Jul 6.

20.

The Food Contaminant Deoxynivalenol Exacerbates the Genotoxicity of Gut Microbiota.

Payros D, Dobrindt U, Martin P, Secher T, Bracarense AP, Boury M, Laffitte J, Pinton P, Oswald E, Oswald IP.

MBio. 2017 Mar 14;8(2). pii: e00007-17. doi: 10.1128/mBio.00007-17.

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