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Increased intracellular Cl- concentration promotes ongoing inflammation in airway epithelium.

Zhang YL, Chen PX, Guan WJ, Guo HM, Qiu ZE, Xu JW, Luo YL, Lan CF, Xu JB, Hao Y, Tan YX, Ye KN, Lun ZR, Zhao L, Zhu YX, Huang J, Ko WH, Zhong WD, Zhou WL, Zhong NS.

Mucosal Immunol. 2018 Jul;11(4):1149-1157. doi: 10.1038/s41385-018-0013-8. Epub 2018 Mar 15.


CFTR is a pattern recognition molecule that extracts Pseudomonas aeruginosa LPS from the outer membrane into epithelial cells and activates NF-kappa B translocation.

Schroeder TH, Lee MM, Yacono PW, Cannon CL, Gerçeker AA, Golan DE, Pier GB.

Proc Natl Acad Sci U S A. 2002 May 14;99(10):6907-12. Epub 2002 May 7.


Flagellin-stimulated Cl- secretion and innate immune responses in airway epithelia: role for p38.

Illek B, Fu Z, Schwarzer C, Banzon T, Jalickee S, Miller SS, Machen TE.

Am J Physiol Lung Cell Mol Physiol. 2008 Oct;295(4):L531-42. doi: 10.1152/ajplung.90292.2008. Epub 2008 Jul 25.


Innate immune response in CF airway epithelia: hyperinflammatory?

Machen TE.

Am J Physiol Cell Physiol. 2006 Aug;291(2):C218-30. Review.


Airway epithelium controls lung inflammation and injury through the NF-kappa B pathway.

Cheng DS, Han W, Chen SM, Sherrill TP, Chont M, Park GY, Sheller JR, Polosukhin VV, Christman JW, Yull FE, Blackwell TS.

J Immunol. 2007 May 15;178(10):6504-13.


TLR-4-mediated innate immunity is reduced in cystic fibrosis airway cells.

John G, Yildirim AO, Rubin BK, Gruenert DC, Henke MO.

Am J Respir Cell Mol Biol. 2010 Apr;42(4):424-31. doi: 10.1165/rcmb.2008-0408OC. Epub 2009 Jun 5.


Decrease of intracellular chloride concentration promotes endothelial cell inflammation by activating nuclear factor-κB pathway.

Yang H, Huang LY, Zeng DY, Huang EW, Liang SJ, Tang YB, Su YX, Tao J, Shang F, Wu QQ, Xiong LX, Lv XF, Liu J, Guan YY, Zhou JG.

Hypertension. 2012 Nov;60(5):1287-93. doi: 10.1161/HYPERTENSIONAHA.112.198648. Epub 2012 Sep 24.


Serum and glucocorticoid-inducible kinase1 increases plasma membrane wt-CFTR in human airway epithelial cells by inhibiting its endocytic retrieval.

Bomberger JM, Coutermarsh BA, Barnaby RL, Sato JD, Chapline MC, Stanton BA.

PLoS One. 2014 Feb 21;9(2):e89599. doi: 10.1371/journal.pone.0089599. eCollection 2014.


Pseudomonas aeruginosa Homoserine lactone activates store-operated cAMP and cystic fibrosis transmembrane regulator-dependent Cl- secretion by human airway epithelia.

Schwarzer C, Wong S, Shi J, Matthes E, Illek B, Ianowski JP, Arant RJ, Isacoff E, Vais H, Foskett JK, Maiellaro I, Hofer AM, Machen TE.

J Biol Chem. 2010 Nov 5;285(45):34850-63. doi: 10.1074/jbc.M110.167668. Epub 2010 Aug 25.


Increased intracellular Cl- concentration mediates Trichomonas vaginalis-induced inflammation in the human vaginal epithelium.

Xu JB, Zhang YL, Huang J, Lu SJ, Sun Q, Chen PX, Jiang P, Qiu ZE, Jiang FN, Zhu YX, Lai DH, Zhong WD, Lun ZR, Zhou WL.

Int J Parasitol. 2019 Jun 26. pii: S0020-7519(19)30166-3. doi: 10.1016/j.ijpara.2019.04.005. [Epub ahead of print]


Serum- and glucocorticoid-induced protein kinase 1 (SGK1) increases the cystic fibrosis transmembrane conductance regulator (CFTR) in airway epithelial cells by phosphorylating Shank2E protein.

Koeppen K, Coutermarsh BA, Madden DR, Stanton BA.

J Biol Chem. 2014 Jun 13;289(24):17142-50. doi: 10.1074/jbc.M114.555599. Epub 2014 May 8.


Pseudomonas aeruginosa-induced apoptosis in airway epithelial cells is mediated by gap junctional communication in a JNK-dependent manner.

Losa D, Köhler T, Bellec J, Dudez T, Crespin S, Bacchetta M, Boulanger P, Hong SS, Morel S, Nguyen TH, van Delden C, Chanson M.

J Immunol. 2014 May 15;192(10):4804-12. doi: 10.4049/jimmunol.1301294. Epub 2014 Apr 14.


The effect of ambroxol on chloride transport, CFTR and ENaC in cystic fibrosis airway epithelial cells.

Varelogianni G, Hussain R, Strid H, Oliynyk I, Roomans GM, Johannesson M.

Cell Biol Int. 2013 Nov;37(11):1149-56. doi: 10.1002/cbin.10146. Epub 2013 Jul 23.


Pivotal role of serum- and glucocorticoid-inducible kinase 1 in vascular inflammation and atherogenesis.

Borst O, Schaub M, Walker B, Schmid E, Münzer P, Voelkl J, Alesutan I, Rodríguez JM, Vogel S, Schoenberger T, Metzger K, Rath D, Umbach A, Kuhl D, Müller II, Seizer P, Geisler T, Gawaz M, Lang F.

Arterioscler Thromb Vasc Biol. 2015 Mar;35(3):547-57. doi: 10.1161/ATVBAHA.114.304454. Epub 2015 Jan 22.


Inhibition of serum- and glucocorticoid-inducible kinase 1 enhances TLR-mediated inflammation and promotes endotoxin-driven organ failure.

Zhou H, Gao S, Duan X, Liang S, Scott DA, Lamont RJ, Wang H.

FASEB J. 2015 Sep;29(9):3737-49. doi: 10.1096/fj.15-270462. Epub 2015 May 20.


YCG063 inhibits Pseudomonas aeruginosa LPS-induced inflammation in human retinal pigment epithelial cells through the TLR2-mediated AKT/NF-κB pathway and ROS-independent pathways.

Paeng SH, Park WS, Jung WK, Lee DS, Kim GY, Choi YH, Seo SK, Jang WH, Choi JS, Lee YM, Park S, Choi IW.

Int J Mol Med. 2015 Sep;36(3):808-16. doi: 10.3892/ijmm.2015.2266. Epub 2015 Jun 30.


CFTR, chloride concentration and cell volume: could mammalian protein histidine phosphorylation play a latent role?

Treharne KJ, Crawford RM, Mehta A.

Exp Physiol. 2006 Jan;91(1):131-9. Epub 2005 Oct 11. Review.


NF-kappaB inhibits sodium transport via down-regulation of SGK1 in renal collecting duct principal cells.

de Seigneux S, Leroy V, Ghzili H, Rousselot M, Nielsen S, Rossier BC, Martin PY, Féraille E.

J Biol Chem. 2008 Sep 12;283(37):25671-81. doi: 10.1074/jbc.M803812200. Epub 2008 Jun 27.

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