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Multiple genetically modified GTKO/hCD46/HLA-E/hβ2-mg porcine hearts are protected from complement activation and natural killer cell infiltration during ex vivo perfusion with human blood.

Abicht JM, Sfriso R, Reichart B, Längin M, Gahle K, Puga Yung GL, Seebach JD, Rieben R, Ayares D, Wolf E, Klymiuk N, Baehr A, Kind A, Mayr T, Bauer A.

Xenotransplantation. 2018 Sep;25(5):e12390. doi: 10.1111/xen.12390. Epub 2018 Mar 14.


Release of pig leukocytes and reduced human NK cell recruitment during ex vivo perfusion of HLA-E/human CD46 double-transgenic pig limbs with human blood.

Puga Yung G, Bongoni AK, Pradier A, Madelon N, Papaserafeim M, Sfriso R, Ayares DL, Wolf E, Klymiuk N, Bähr A, Constantinescu MA, Voegelin E, Kiermeir D, Jenni H, Rieben R, Seebach JD.

Xenotransplantation. 2018 Jan;25(1). doi: 10.1111/xen.12357. Epub 2017 Oct 22.


Transgenic expression of human leukocyte antigen-E attenuates GalKO.hCD46 porcine lung xenograft injury.

Laird CT, Burdorf L, French BM, Kubicki N, Cheng X, Braileanu G, Sun W, O'Neill NA, Cimeno A, Parsell D, So E, Bähr A, Klymiuk N, Phelps CJ, Ayares D, Azimzadeh AM, Pierson RN.

Xenotransplantation. 2017 Mar;24(2). doi: 10.1111/xen.12294. Epub 2017 Mar 3.


Complement dependent early immunological responses during ex vivo xenoperfusion of hCD46/HLA-E double transgenic pig forelimbs with human blood.

Bongoni AK, Kiermeir D, Jenni H, Bähr A, Ayares D, Klymiuk N, Wolf E, Voegelin E, Constantinescu MA, Seebach JD, Rieben R.

Xenotransplantation. 2014 May-Jun;21(3):230-43. doi: 10.1111/xen.12090. Epub 2014 Mar 17.


Inhibition of complement component C5 prevents clotting in an ex vivo model of xenogeneic activation of coagulation.

Rataj D, Werwitzke S, Haarmeijer B, Winkler M, Ramackers W, Petersen B, Niemann H, Wünsch A, Bähr A, Klymiuk N, Wolf E, Abicht JM, Ayares D, Tiede A.

Xenotransplantation. 2016 Mar;23(2):117-27. doi: 10.1111/xen.12218. Epub 2016 Jan 16.


Complement C3 inhibitor Cp40 attenuates xenoreactions in pig hearts perfused with human blood.

Abicht JM, Kourtzelis I, Reichart B, Koutsogiannaki S, Primikyri A, Lambris JD, Chavakis T, Holdt L, Kind A, Guethoff S, Mayr T.

Xenotransplantation. 2017 Jan;24(1). doi: 10.1111/xen.12262. Epub 2016 Sep 27.


Meta-analysis of the independent and cumulative effects of multiple genetic modifications on pig lung xenograft performance during ex vivo perfusion with human blood.

Harris DG, Quinn KJ, French BM, Schwartz E, Kang E, Dahi S, Phelps CJ, Ayares DL, Burdorf L, Azimzadeh AM, Pierson RN 3rd.

Xenotransplantation. 2015 Mar-Apr;22(2):102-11. doi: 10.1111/xen.12149. Epub 2014 Dec 2.


HLA-E/human beta2-microglobulin transgenic pigs: protection against xenogeneic human anti-pig natural killer cell cytotoxicity.

Weiss EH, Lilienfeld BG, Müller S, Müller E, Herbach N, Kessler B, Wanke R, Schwinzer R, Seebach JD, Wolf E, Brem G.

Transplantation. 2009 Jan 15;87(1):35-43. doi: 10.1097/TP.0b013e318191c784.


Expression of human CD59 in transgenic pig organs enhances organ survival in an ex vivo xenogeneic perfusion model.

Kroshus TJ, Bolman RM 3rd, Dalmasso AP, Rollins SA, Guilmette ER, Williams BL, Squinto SP, Fodor WL.

Transplantation. 1996 May 27;61(10):1513-21.


Initial in vitro studies on tissues and cells from GTKO/CD46/NeuGcKO pigs.

Lee W, Hara H, Ezzelarab MB, Iwase H, Bottino R, Long C, Ramsoondar J, Ayares D, Cooper DK.

Xenotransplantation. 2016 Mar;23(2):137-50. doi: 10.1111/xen.12229. Epub 2016 Mar 14.


Activation of the lectin pathway of complement in pig-to-human xenotransplantation models.

Bongoni AK, Kiermeir D, Jenni H, Wünsch A, Bähr A, Ayares D, Seebach JD, Wolf E, Klymiuk N, Constantinescu MA, Vögelin E, Rieben R.

Transplantation. 2013 Nov 15;96(9):791-9. doi: 10.1097/TP.0b013e3182a3a52b.


Surface modification of pig endothelial cells with a branched heparin conjugate improves their compatibility with human blood.

Bongoni AK, Salvaris E, Nordling S, Klymiuk N, Wolf E, Ayares DL, Rieben R, Magnusson PU, Cowan PJ.

Sci Rep. 2017 Jun 30;7(1):4450. doi: 10.1038/s41598-017-04898-w.


Prevention of hyperacute rejection by human decay accelerating factor in xenogeneic perfused working hearts.

Schmoeckel M, Nollert G, Shahmohammadi M, Young VK, Chavez G, Kasper-König W, White DJ, Müller-Höcker J, Arendt RM, Wilbert-Lampen U, Hammer C, Reichart B.

Transplantation. 1996 Sep 27;62(6):729-34.


Human CD55 expression blocks hyperacute rejection and restricts complement activation in Gal knockout cardiac xenografts.

McGregor CG, Ricci D, Miyagi N, Stalboerger PG, Du Z, Oehler EA, Tazelaar HD, Byrne GW.

Transplantation. 2012 Apr 15;93(7):686-92. doi: 10.1097/TP.0b013e3182472850.


CD4+CD25Hi FoxP3+ regulatory T cells in long-term cardiac xenotransplantation.

Singh AK, Chan JL, Seavey CN, Corcoran PC, Hoyt RF Jr, Lewis BGT, Thomas ML, Ayares DL, Horvath KA, Mohiuddin MM.

Xenotransplantation. 2018 Mar;25(2):e12379. doi: 10.1111/xen.12379. Epub 2017 Dec 17.


Transgenic expression of HLA-E single chain trimer protects porcine endothelial cells against human natural killer cell-mediated cytotoxicity.

Lilienfeld BG, Crew MD, Forte P, Baumann BC, Seebach JD.

Xenotransplantation. 2007 Mar;14(2):126-34.


The Role of NK Cells in Pig-to-Human Xenotransplantation.

Puga Yung G, Schneider MKJ, Seebach JD.

J Immunol Res. 2017;2017:4627384. doi: 10.1155/2017/4627384. Epub 2017 Dec 19. Review.


Transgenic Expression of Human CD46 on Porcine Endothelium: Effect on Coagulation and Fibrinolytic Cascades During Ex Vivo Human-to-Pig Limb Xenoperfusions.

Bongoni AK, Kiermeir D, Schnider J, Jenni H, Garimella P, Bähr A, Klymiuk N, Wolf E, Ayares D, Voegelin E, Constantinescu MA, Seebach JD, Rieben R.

Transplantation. 2015 Oct;99(10):2061-9. doi: 10.1097/TP.0000000000000746.


Expression of human CD46 modulates inflammation associated with GalTKO lung xenograft injury.

Burdorf L, Stoddard T, Zhang T, Rybak E, Riner A, Avon C, Laaris A, Cheng X, Sievert E, Braileanu G, Newton A, Phelps CJ, Ayares D, Azimzadeh AM, Pierson RN 3rd.

Am J Transplant. 2014 May;14(5):1084-95. doi: 10.1111/ajt.12673. Epub 2014 Apr 2.


Platelet sequestration and activation during GalTKO.hCD46 pig lung perfusion by human blood is primarily mediated by GPIb, GPIIb/IIIa, and von Willebrand Factor.

Burdorf L, Riner A, Rybak E, Salles II, De Meyer SF, Shah A, Quinn KJ, Harris D, Zhang T, Parsell D, Ali F, Schwartz E, Kang E, Cheng X, Sievert E, Zhao Y, Braileanu G, Phelps CJ, Ayares DL, Deckmyn H, Pierson RN 3rd, Azimzadeh AM, Dandro A, Karavi K.

Xenotransplantation. 2016 May;23(3):222-236. doi: 10.1111/xen.12236. Epub 2016 May 18. Erratum in: Xenotransplantation. 2016 Sep;23(5):423.

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