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FOXO3a Provides a Quickstep from Autophagy Inhibition to Apoptosis in Cancer Therapy.

Codogno P, Morel E.

Dev Cell. 2018 Mar 12;44(5):537-539. doi: 10.1016/j.devcel.2018.02.019.


Autophagy Inhibition Mediates Apoptosis Sensitization in Cancer Therapy by Relieving FOXO3a Turnover.

Fitzwalter BE, Towers CG, Sullivan KD, Andrysik Z, Hoh M, Ludwig M, O'Prey J, Ryan KM, Espinosa JM, Morgan MJ, Thorburn A.

Dev Cell. 2018 Mar 12;44(5):555-565.e3. doi: 10.1016/j.devcel.2018.02.014.


FOXO3 links autophagy to apoptosis.

Fitzwalter BE, Thorburn A.

Autophagy. 2018;14(8):1467-1468. doi: 10.1080/15548627.2018.1475819. Epub 2018 Jul 21.


Estrogen receptor β upregulates FOXO3a and causes induction of apoptosis through PUMA in prostate cancer.

Dey P, Ström A, Gustafsson JÅ.

Oncogene. 2014 Aug 14;33(33):4213-25. doi: 10.1038/onc.2013.384. Epub 2013 Sep 30.


Inhibition of AKT/FoxO3a signaling induced PUMA expression in response to p53-independent cytotoxic effects of H1: A derivative of tetrandrine.

Zhang YX, Liu XM, Wang J, Li J, Liu Y, Zhang H, Yu XW, Wei N.

Cancer Biol Ther. 2015;16(6):965-75. doi: 10.1080/15384047.2015.1040950. Epub 2015 Apr 20.


Myc and PI3K/AKT signaling cooperatively repress FOXO3a-dependent PUMA and GADD45a gene expression.

Amente S, Zhang J, Lavadera ML, Lania L, Avvedimento EV, Majello B.

Nucleic Acids Res. 2011 Dec;39(22):9498-507. doi: 10.1093/nar/gkr638. Epub 2011 Aug 10. Erratum in: Nucleic Acids Res. 2014 Feb;42(3):2098.


Inhibition of AKT promotes FOXO3a-dependent apoptosis in prostate cancer.

Das TP, Suman S, Alatassi H, Ankem MK, Damodaran C.

Cell Death Dis. 2016 Feb 25;7:e2111. doi: 10.1038/cddis.2015.403.


Upregulation of forkhead box O3 transcription is involved in C2-ceramide induced apoptosis and autophagy in ovarian cancer cells in vitro.

Jin Z, Zheng L, Xin X, Li Y, Hua T, Wu T, Wang H.

Mol Med Rep. 2014 Dec;10(6):3099-105. doi: 10.3892/mmr.2014.2664. Epub 2014 Oct 15.


Melatonin induces transcriptional regulation of Bim by FoxO3a in HepG2 cells.

Carbajo-Pescador S, Steinmetz C, Kashyap A, Lorenz S, Mauriz JL, Heise M, Galle PR, González-Gallego J, Strand S.

Br J Cancer. 2013 Feb 5;108(2):442-9. doi: 10.1038/bjc.2012.563. Epub 2012 Dec 20.


The essential role of p53-up-regulated modulator of apoptosis (Puma) and its regulation by FoxO3a transcription factor in β-amyloid-induced neuron death.

Akhter R, Sanphui P, Biswas SC.

J Biol Chem. 2014 Apr 11;289(15):10812-22. doi: 10.1074/jbc.M113.519355. Epub 2014 Feb 24.


CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress.

Ghosh AP, Klocke BJ, Ballestas ME, Roth KA.

PLoS One. 2012;7(6):e39586. doi: 10.1371/journal.pone.0039586. Epub 2012 Jun 28.


JNK- and Akt-mediated Puma expression in the apoptosis of cisplatin-resistant ovarian cancer cells.

Zhao Z, Wang J, Tang J, Liu X, Zhong Q, Wang F, Hu W, Yuan Z, Nie C, Wei Y.

Biochem J. 2012 Jun 1;444(2):291-301. doi: 10.1042/BJ20111855.


Subcellular localization of FOXO3a as a potential biomarker of response to combined treatment with inhibitors of PI3K and autophagy in PIK3CA-mutant cancer cells.

Kim HJ, Lee SY, Kim CY, Kim YH, Ju W, Kim SC.

Oncotarget. 2017 Jan 24;8(4):6608-6622. doi: 10.18632/oncotarget.14245.


Autophagy induction by leptin contributes to suppression of apoptosis in cancer cells and xenograft model: involvement of p53/FoxO3A axis.

Nepal S, Kim MJ, Hong JT, Kim SH, Sohn DH, Lee SH, Song K, Choi DY, Lee ES, Park PH.

Oncotarget. 2015 Mar 30;6(9):7166-81.


FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal.

You H, Pellegrini M, Tsuchihara K, Yamamoto K, Hacker G, Erlacher M, Villunger A, Mak TW.

J Exp Med. 2006 Jul 10;203(7):1657-63. Epub 2006 Jun 26.


Dihydromyricetin protects against liver ischemia/reperfusion induced apoptosis via activation of FOXO3a-mediated autophagy.

Chen Y, Lv L, Pi H, Qin W, Chen J, Guo D, Lin J, Chi X, Jiang Z, Yang H, Jiang Y.

Oncotarget. 2016 Nov 22;7(47):76508-76522. doi: 10.18632/oncotarget.12894.


Apoptosis induction by MEK inhibition in human lung cancer cells is mediated by Bim.

Meng J, Fang B, Liao Y, Chresta CM, Smith PD, Roth JA.

PLoS One. 2010 Sep 27;5(9):e13026. doi: 10.1371/journal.pone.0013026.


PUMA induction by FoxO3a mediates the anticancer activities of the broad-range kinase inhibitor UCN-01.

Dudgeon C, Wang P, Sun X, Peng R, Sun Q, Yu J, Zhang L.

Mol Cancer Ther. 2010 Nov;9(11):2893-902. doi: 10.1158/1535-7163.MCT-10-0635. Epub 2010 Oct 26.


Forkhead box protein O3 suppresses uveal melanoma development by increasing the expression of Bcl‑2‑like protein 11 and cyclin‑dependent kinase inhibitor 1B.

Yan F, Liao R, Lin S, Deng X, Little PJ, Zheng W.

Mol Med Rep. 2018 Feb;17(2):3109-3114. doi: 10.3892/mmr.2017.8215. Epub 2017 Dec 7.


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