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Contribution of Adipose-Derived Factor D/Adipsin to Complement Alternative Pathway Activation: Lessons from Lipodystrophy.

Wu X, Hutson I, Akk AM, Mascharak S, Pham CTN, Hourcade DE, Brown R, Atkinson JP, Harris CA.

J Immunol. 2018 Apr 15;200(8):2786-2797. doi: 10.4049/jimmunol.1701668. Epub 2018 Mar 12.


Complement Factor D protects mice from ethanol-induced inflammation and liver injury.

McCullough RL, McMullen MR, Sheehan MM, Poulsen KL, Roychowdhury S, Chiang DJ, Pritchard MT, Caballeria J, Nagy LE.

Am J Physiol Gastrointest Liver Physiol. 2018 Jul 1;315(1):G66-G79. doi: 10.1152/ajpgi.00334.2017. Epub 2018 Mar 29.


Serum concentrations of fibroblast growth factor 21 are elevated in patients with congenital or acquired lipodystrophy.

Miehle K, Ebert T, Kralisch S, Hoffmann A, Kratzsch J, Schlögl H, Stumvoll M, Fasshauer M.

Cytokine. 2016 Jul;83:239-244. doi: 10.1016/j.cyto.2016.04.015. Epub 2016 May 11.


Progranulin is increased in human and murine lipodystrophy.

Miehle K, Ebert T, Kralisch S, Hoffmann A, Kratzsch J, Schlögl H, Stumvoll M, Fasshauer M.

Diabetes Res Clin Pract. 2016 Oct;120:1-7. doi: 10.1016/j.diabres.2016.07.017. Epub 2016 Jul 30.


Adipsin and complement factor D activity: an immune-related defect in obesity.

Rosen BS, Cook KS, Yaglom J, Groves DL, Volanakis JE, Damm D, White T, Spiegelman BM.

Science. 1989 Jun 23;244(4911):1483-7.


Inhibition of complement alternative pathway in mice with Fab antibody to recombinant adipsin/factor D.

Pascual M, Catana E, White T, Spiegelman BM, Schifferli JA.

Eur J Immunol. 1993 Jun;23(6):1389-92.


Roles of adipocytes and fibroblasts in activation of the alternative pathway of complement in inflammatory arthritis in mice.

Arend WP, Mehta G, Antonioli AH, Takahashi M, Takahashi K, Stahl GL, Holers VM, Banda NK.

J Immunol. 2013 Jun 15;190(12):6423-33. doi: 10.4049/jimmunol.1300580. Epub 2013 May 6.


Small-molecule factor D inhibitors targeting the alternative complement pathway.

Maibaum J, Liao SM, Vulpetti A, Ostermann N, Randl S, Rüdisser S, Lorthiois E, Erbel P, Kinzel B, Kolb FA, Barbieri S, Wagner J, Durand C, Fettis K, Dussauge S, Hughes N, Delgado O, Hommel U, Gould T, Mac Sweeney A, Gerhartz B, Cumin F, Flohr S, Schubart A, Jaffee B, Harrison R, Risitano AM, Eder J, Anderson K.

Nat Chem Biol. 2016 Dec;12(12):1105-1110. doi: 10.1038/nchembio.2208. Epub 2016 Oct 24.


Complement activation pathways in murine immune complex-induced arthritis and in C3a and C5a generation in vitro.

Banda NK, Levitt B, Wood AK, Takahashi K, Stahl GL, Holers VM, Arend WP.

Clin Exp Immunol. 2010 Jan;159(1):100-8. doi: 10.1111/j.1365-2249.2009.04035.x. Epub 2009 Oct 19.


Adipsin and an endogenous pathway of complement from adipose cells.

Choy LN, Rosen BS, Spiegelman BM.

J Biol Chem. 1992 Jun 25;267(18):12736-41.


Lutein and Factor D: two intriguing players in the field of age-related macular degeneration.

Tian Y, Kijlstra A, Webers CAB, Berendschot TTJM.

Arch Biochem Biophys. 2015 Apr 15;572:49-53. doi: 10.1016/ Epub 2015 Jan 28. Review.


MASP-3 is the exclusive pro-factor D activator in resting blood: the lectin and the alternative complement pathways are fundamentally linked.

Dobó J, Szakács D, Oroszlán G, Kortvely E, Kiss B, Boros E, Szász R, Závodszky P, Gál P, Pál G.

Sci Rep. 2016 Aug 18;6:31877. doi: 10.1038/srep31877.


Human adipsin is identical to complement factor D and is expressed at high levels in adipose tissue.

White RT, Damm D, Hancock N, Rosen BS, Lowell BB, Usher P, Flier JS, Spiegelman BM.

J Biol Chem. 1992 May 5;267(13):9210-3.


Analysis of Factor D Isoforms in Malpuech-Michels-Mingarelli-Carnevale Patients Highlights the Role of MASP-3 as a Maturase in the Alternative Pathway of Complement.

Pihl R, Jensen L, Hansen AG, Thøgersen IB, Andres S, Dagnæs-Hansen F, Oexle K, Enghild JJ, Thiel S.

J Immunol. 2017 Aug 9. pii: ji1700518. doi: 10.4049/jimmunol.1700518. [Epub ahead of print]


Circulating serum chemerin levels are elevated in lipodystrophy.

Miehle K, Ebert T, Kralisch S, Hoffmann A, Kratzsch J, Schlögl H, Stumvoll M, Fasshauer M.

Clin Endocrinol (Oxf). 2016 Jun;84(6):932-8. doi: 10.1111/cen.12976. Epub 2015 Dec 15.


The down-stream effects of mannan-induced lectin complement pathway activation depend quantitatively on alternative pathway amplification.

Harboe M, Garred P, Karlstrøm E, Lindstad JK, Stahl GL, Mollnes TE.

Mol Immunol. 2009 Dec;47(2-3):373-80. doi: 10.1016/j.molimm.2009.09.005. Epub 2009 Oct 1.


Modest release of adipsin/factor D by liposuction when using the superwet or tumescent technique.

Samdal F, Mollnes TE, Amland PF, Truedsson L.

Plast Reconstr Surg. 1997 May;99(6):1591-4; discussion 1595-6.


Essential role of complement mannose-binding lectin-associated serine proteases-1/3 in the murine collagen antibody-induced model of inflammatory arthritis.

Banda NK, Takahashi M, Levitt B, Glogowska M, Nicholas J, Takahashi K, Stahl GL, Fujita T, Arend WP, Holers VM.

J Immunol. 2010 Nov 1;185(9):5598-606. doi: 10.4049/jimmunol.1001564. Epub 2010 Sep 24.


Regulation of plasma PAI-1 concentrations in HAART-associated lipodystrophy during rosiglitazone therapy.

Yki-Järvinen H, Sutinen J, Silveira A, Korsheninnikova E, Fisher RM, Kannisto K, Ehrenborg E, Eriksson P, Hamsten A.

Arterioscler Thromb Vasc Biol. 2003 Apr 1;23(4):688-94. Epub 2003 Feb 20.


MASP-1 and MASP-2 Do Not Activate Pro-Factor D in Resting Human Blood, whereas MASP-3 Is a Potential Activator: Kinetic Analysis Involving Specific MASP-1 and MASP-2 Inhibitors.

Oroszlán G, Kortvely E, Szakács D, Kocsis A, Dammeier S, Zeck A, Ueffing M, Závodszky P, Pál G, Gál P, Dobó J.

J Immunol. 2016 Jan 15;196(2):857-65. doi: 10.4049/jimmunol.1501717. Epub 2015 Dec 16.

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