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Items: 1 to 20 of 106

1.

In Silico Identification and Experimental Validation of Novel Anti-Alzheimer's Multitargeted Ligands from a Marine Source Featuring a "2-Aminoimidazole plus Aromatic Group" Scaffold.

Vitale RM, Rispoli V, Desiderio D, Sgammato R, Thellung S, Canale C, Vassalli M, Carbone M, Ciavatta ML, Mollo E, Felicità V, Arcone R, Gavagnin Capoggiani M, Masullo M, Florio T, Amodeo P.

ACS Chem Neurosci. 2018 Jun 20;9(6):1290-1303. doi: 10.1021/acschemneuro.7b00416. Epub 2018 Mar 7.

PMID:
29473731
2.

Development of cyanopyridine-triazine hybrids as lead multitarget anti-Alzheimer agents.

Maqbool M, Manral A, Jameel E, Kumar J, Saini V, Shandilya A, Tiwari M, Hoda N, Jayaram B.

Bioorg Med Chem. 2016 Jun 15;24(12):2777-88. doi: 10.1016/j.bmc.2016.04.041. Epub 2016 Apr 22.

PMID:
27157006
3.

Uleine Disrupts Key Enzymatic and Non-Enzymatic Biomarkers that Leads to Alzheimer's Disease.

Seidl C, de Moraes Santos CA, De Simone A, Bartolini M, Weffort-Santos AM, Andrisano V.

Curr Alzheimer Res. 2017;14(3):317-326. doi: 10.2174/1567205013666161026150455.

PMID:
27784218
4.

Biological evaluation of synthetic α,β-unsaturated carbonyl based cyclohexanone derivatives as neuroprotective novel inhibitors of acetylcholinesterase, butyrylcholinesterase and amyloid-β aggregation.

Zha GF, Zhang CP, Qin HL, Jantan I, Sher M, Amjad MW, Hussain MA, Hussain Z, Bukhari SN.

Bioorg Med Chem. 2016 May 15;24(10):2352-9. doi: 10.1016/j.bmc.2016.04.015. Epub 2016 Apr 8.

PMID:
27083471
5.

Multiple Ligands Targeting Cholinesterases and β-Amyloid: Synthesis, Biological Evaluation of Heterodimeric Compounds with Benzylamine Pharmacophore.

Szałaj N, Bajda M, Dudek K, Brus B, Gobec S, Malawska B.

Arch Pharm (Weinheim). 2015 Aug;348(8):556-63. doi: 10.1002/ardp.201500117. Epub 2015 May 29.

PMID:
26032855
6.

New cyclopentaquinoline hybrids with multifunctional capacities for the treatment of Alzheimer's disease.

Czarnecka K, Girek M, Maciejewska K, Skibiński R, Jończyk J, Bajda M, Kabziński J, Sołowiej P, Majsterek I, Szymański P.

J Enzyme Inhib Med Chem. 2017 Dec;33(1):158-170. doi: 10.1080/14756366.2017.1406485. Erratum in: J Enzyme Inhib Med Chem. 2018 Dec;33(1):558-559.

7.

Novel deoxyvasicinone derivatives as potent multitarget-directed ligands for the treatment of Alzheimer's disease: Design, synthesis, and biological evaluation.

Ma F, Du H.

Eur J Med Chem. 2017 Nov 10;140:118-127. doi: 10.1016/j.ejmech.2017.09.008. Epub 2017 Sep 8.

PMID:
28923380
8.

Design of multi-target compounds as AChE, BACE1, and amyloid-β(1-42) oligomerization inhibitors: in silico and in vitro studies.

Hernández-Rodríguez M, Correa-Basurto J, Martínez-Ramos F, Padilla-Martínez II, Benítez-Cardoza CG, Mera-Jiménez E, Rosales-Hernández MC.

J Alzheimers Dis. 2014;41(4):1073-85. doi: 10.3233/JAD-140471.

PMID:
24762947
9.

Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease.

Jeřábek J, Uliassi E, Guidotti L, Korábečný J, Soukup O, Sepsova V, Hrabinova M, Kuča K, Bartolini M, Peña-Altamira LE, Petralla S, Monti B, Roberti M, Bolognesi ML.

Eur J Med Chem. 2017 Feb 15;127:250-262. doi: 10.1016/j.ejmech.2016.12.048. Epub 2016 Dec 26.

PMID:
28064079
10.

Tacrine-based Multifunctional Agents in Alzheimer's Disease: An Old Story in Continuous Development§.

Milelli A, De Simone A, Ticchi N, Chen HH, Betari N, Andrisano V, Tumiatti V.

Curr Med Chem. 2017;24(32):3522-3546. doi: 10.2174/0929867324666170309123920. Review.

PMID:
28294041
11.

Synthesis, in vitro assay, and molecular modeling of new piperidine derivatives having dual inhibitory potency against acetylcholinesterase and Abeta1-42 aggregation for Alzheimer's disease therapeutics.

Kwon YE, Park JY, No KT, Shin JH, Lee SK, Eun JS, Yang JH, Shin TY, Kim DK, Chae BS, Leem JY, Kim KH.

Bioorg Med Chem. 2007 Oct 15;15(20):6596-607. Epub 2007 Jul 25.

PMID:
17681794
12.

Recent advances in the multitarget-directed ligands approach for the treatment of Alzheimer's disease.

León R, Garcia AG, Marco-Contelles J.

Med Res Rev. 2013 Jan;33(1):139-89. doi: 10.1002/med.20248. Epub 2011 Jul 26. Review.

PMID:
21793014
13.

Design, synthesis and biological evaluation of benzo[e][1,2,4]triazin-7(1H)-one and [1,2,4]-triazino[5,6,1-jk]carbazol-6-one derivatives as dual inhibitors of beta-amyloid aggregation and acetyl/butyryl cholinesterase.

Catto M, Berezin AA, Lo Re D, Loizou G, Demetriades M, De Stradis A, Campagna F, Koutentis PA, Carotti A.

Eur J Med Chem. 2012 Dec;58:84-97. doi: 10.1016/j.ejmech.2012.10.003. Epub 2012 Oct 11.

PMID:
23108363
14.

Rational design, synthesis and biological screening of triazine-triazolopyrimidine hybrids as multitarget anti-Alzheimer agents.

Jameel E, Meena P, Maqbool M, Kumar J, Ahmed W, Mumtazuddin S, Tiwari M, Hoda N, Jayaram B.

Eur J Med Chem. 2017 Aug 18;136:36-51. doi: 10.1016/j.ejmech.2017.04.064. Epub 2017 Apr 24.

PMID:
28478343
15.

Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease.

Rosini M, Simoni E, Bartolini M, Tarozzi A, Matera R, Milelli A, Hrelia P, Andrisano V, Bolognesi ML, Melchiorre C.

Eur J Med Chem. 2011 Nov;46(11):5435-42. doi: 10.1016/j.ejmech.2011.09.001. Epub 2011 Sep 8.

PMID:
21924801
16.

Novel Multitarget-Directed Ligands Aiming at Symptoms and Causes of Alzheimer's Disease.

Więckowska A, Wichur T, Godyń J, Bucki A, Marcinkowska M, Siwek A, Więckowski K, Zaręba P, Knez D, Głuch-Lutwin M, Kazek G, Latacz G, Mika K, Kołaczkowski M, Korabecny J, Soukup O, Benkova M, Kieć-Kononowicz K, Gobec S, Malawska B.

ACS Chem Neurosci. 2018 May 16;9(5):1195-1214. doi: 10.1021/acschemneuro.8b00024. Epub 2018 Feb 13.

PMID:
29384656
17.

Antiaggregation Potential of Padina gymnospora against the Toxic Alzheimer's Beta-Amyloid Peptide 25-35 and Cholinesterase Inhibitory Property of Its Bioactive Compounds.

Shanmuganathan B, Sheeja Malar D, Sathya S, Pandima Devi K.

PLoS One. 2015 Nov 4;10(11):e0141708. doi: 10.1371/journal.pone.0141708. eCollection 2015.

18.

2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents.

Rizzo S, Tarozzi A, Bartolini M, Da Costa G, Bisi A, Gobbi S, Belluti F, Ligresti A, Allarà M, Monti JP, Andrisano V, Di Marzo V, Hrelia P, Rampa A.

Eur J Med Chem. 2012 Dec;58:519-32. doi: 10.1016/j.ejmech.2012.10.045. Epub 2012 Nov 2.

PMID:
23164658
19.

New tacrine-acridine hybrids as promising multifunctional drugs for potential treatment of Alzheimer's disease.

Chufarova N, Czarnecka K, Skibiński R, Cuchra M, Majsterek I, Szymański P.

Arch Pharm (Weinheim). 2018 Jul;351(7):e1800050. doi: 10.1002/ardp.201800050. Epub 2018 Jun 5.

PMID:
29870588
20.

Design, Synthesis, and Biological Evaluation of 1-Benzylamino-2-hydroxyalkyl Derivatives as New Potential Disease-Modifying Multifunctional Anti-Alzheimer's Agents.

Panek D, Więckowska A, Jończyk J, Godyń J, Bajda M, Wichur T, Pasieka A, Knez D, Pišlar A, Korabecny J, Soukup O, Sepsova V, Sabaté R, Kos J, Gobec S, Malawska B.

ACS Chem Neurosci. 2018 May 16;9(5):1074-1094. doi: 10.1021/acschemneuro.7b00461. Epub 2018 Feb 1.

PMID:
29345897

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