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Items: 1 to 20 of 82

1.

The Airway Transcriptome as a Biomarker for Early Lung Cancer Detection.

Billatos E, Vick JL, Lenburg ME, Spira AE.

Clin Cancer Res. 2018 Jul 1;24(13):2984-2992. doi: 10.1158/1078-0432.CCR-16-3187. Epub 2018 Feb 20. Review.

PMID:
29463557
2.

Detecting the Presence and Progression of Premalignant Lung Lesions via Airway Gene Expression.

Beane J, Mazzilli SA, Tassinari AM, Liu G, Zhang X, Liu H, Buncio AD, Dhillon SS, Platero SJ, Lenburg ME, Reid ME, Lam S, Spira AE.

Clin Cancer Res. 2017 Sep 1;23(17):5091-5100. doi: 10.1158/1078-0432.CCR-16-2540. Epub 2017 May 22.

3.

Bronchial airway gene expression signatures in mouse lung squamous cell carcinoma and their modulation by cancer chemopreventive agents.

Xiong D, Pan J, Zhang Q, Szabo E, Miller MS, Lubet RA, You M, Wang Y.

Oncotarget. 2017 Mar 21;8(12):18885-18900. doi: 10.18632/oncotarget.13806.

4.

Smoking-induced gene expression changes in the bronchial airway are reflected in nasal and buccal epithelium.

Sridhar S, Schembri F, Zeskind J, Shah V, Gustafson AM, Steiling K, Liu G, Dumas YM, Zhang X, Brody JS, Lenburg ME, Spira A.

BMC Genomics. 2008 May 30;9:259. doi: 10.1186/1471-2164-9-259.

5.

Characterizing the impact of smoking and lung cancer on the airway transcriptome using RNA-Seq.

Beane J, Vick J, Schembri F, Anderlind C, Gower A, Campbell J, Luo L, Zhang XH, Xiao J, Alekseyev YO, Wang S, Levy S, Massion PP, Lenburg M, Spira A.

Cancer Prev Res (Phila). 2011 Jun;4(6):803-17. doi: 10.1158/1940-6207.CAPR-11-0212.

6.

Impact of a bronchial genomic classifier on clinical decision making in patients undergoing diagnostic evaluation for lung cancer.

Ferguson JS, Van Wert R, Choi Y, Rosenbluth MJ, Smith KP, Huang J, Spira A.

BMC Pulm Med. 2016 May 17;16(1):66. doi: 10.1186/s12890-016-0217-1.

7.

A dynamic bronchial airway gene expression signature of chronic obstructive pulmonary disease and lung function impairment.

Steiling K, van den Berge M, Hijazi K, Florido R, Campbell J, Liu G, Xiao J, Zhang X, Duclos G, Drizik E, Si H, Perdomo C, Dumont C, Coxson HO, Alekseyev YO, Sin D, Pare P, Hogg JC, McWilliams A, Hiemstra PS, Sterk PJ, Timens W, Chang JT, Sebastiani P, O'Connor GT, Bild AH, Postma DS, Lam S, Spira A, Lenburg ME.

Am J Respir Crit Care Med. 2013 May 1;187(9):933-42. doi: 10.1164/rccm.201208-1449OC.

8.

Molecular characterization of the peripheral airway field of cancerization in lung adenocarcinoma.

Tsay JC, Li Z, Yie TA, Wu F, Segal L, Greenberg AK, Leibert E, Weiden MD, Pass H, Munger J, Statnikov A, Tchou-Wong KM, Rom WN.

PLoS One. 2015 Feb 23;10(2):e0118132. doi: 10.1371/journal.pone.0118132. eCollection 2015.

9.

Derivation of a bronchial genomic classifier for lung cancer in a prospective study of patients undergoing diagnostic bronchoscopy.

Whitney DH, Elashoff MR, Porta-Smith K, Gower AC, Vachani A, Ferguson JS, Silvestri GA, Brody JS, Lenburg ME, Spira A.

BMC Med Genomics. 2015 May 6;8:18. doi: 10.1186/s12920-015-0091-3.

10.

A Bronchial Genomic Classifier for the Diagnostic Evaluation of Lung Cancer.

Silvestri GA, Vachani A, Whitney D, Elashoff M, Porta Smith K, Ferguson JS, Parsons E, Mitra N, Brody J, Lenburg ME, Spira A; AEGIS Study Team.

N Engl J Med. 2015 Jul 16;373(3):243-51. doi: 10.1056/NEJMoa1504601. Epub 2015 May 17.

11.

Genomic Landscape Established by Allelic Imbalance in the Cancerization Field of a Normal Appearing Airway.

Jakubek Y, Lang W, Vattathil S, Garcia M, Xu L, Huang L, Yoo SY, Shen L, Lu W, Chow CW, Weber Z, Davies G, Huang J, Behrens C, Kalhor N, Moran C, Fujimoto J, Mehran R, El-Zein R, Swisher SG, Wang J, Fowler J, Spira AE, Ehli EA, Wistuba II, Scheet P, Kadara H.

Cancer Res. 2016 Jul 1;76(13):3676-83. doi: 10.1158/0008-5472.CAN-15-3064. Epub 2016 May 23.

12.

Transcriptomic architecture of the adjacent airway field cancerization in non-small cell lung cancer.

Kadara H, Fujimoto J, Yoo SY, Maki Y, Gower AC, Kabbout M, Garcia MM, Chow CW, Chu Z, Mendoza G, Shen L, Kalhor N, Hong WK, Moran C, Wang J, Spira A, Coombes KR, Wistuba II.

J Natl Cancer Inst. 2014 Mar;106(3):dju004. doi: 10.1093/jnci/dju004. Epub 2014 Feb 22.

13.

Detection of early lung cancer among military personnel (DECAMP) consortium: study protocols.

Billatos E, Duan F, Moses E, Marques H, Mahon I, Dymond L, Apgar C, Aberle D, Washko G, Spira A; DECAMP investigators.

BMC Pulm Med. 2019 Mar 7;19(1):59. doi: 10.1186/s12890-019-0825-7.

14.

Enriching the molecular definition of the airway "field of cancerization:" establishing new paradigms for the patient at risk for lung cancer.

Gomperts BN, Walser TC, Spira A, Dubinett SM.

Cancer Prev Res (Phila). 2013 Jan;6(1):4-7. doi: 10.1158/1940-6207.CAPR-12-0470. Epub 2012 Dec 11.

15.

Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer.

Spira A, Beane JE, Shah V, Steiling K, Liu G, Schembri F, Gilman S, Dumas YM, Calner P, Sebastiani P, Sridhar S, Beamis J, Lamb C, Anderson T, Gerry N, Keane J, Lenburg ME, Brody JS.

Nat Med. 2007 Mar;13(3):361-6. Epub 2007 Mar 4.

PMID:
17334370
16.

Sputum-based molecular biomarkers for the early detection of lung cancer: limitations and promise.

Kim CE, Tchou-Wong KM, Rom WN.

Cancers (Basel). 2011 Jul 19;3(3):2975-89. doi: 10.3390/cancers3032975.

17.

Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer.

Wang X, Chorley BN, Pittman GS, Kleeberger SR, Brothers J 2nd, Liu G, Spira A, Bell DA.

PLoS One. 2010 Aug 3;5(8):e11934. doi: 10.1371/journal.pone.0011934.

18.

Airway brushing as a new experimental methodology to detect airway gene expression signatures in mouse lung squamous cell carcinoma.

Pan J, Xiong D, Zhang Q, Szabo E, Miller MS, Lubet RA, Wang Y, You M.

Sci Rep. 2018 Jun 11;8(1):8895. doi: 10.1038/s41598-018-26902-7.

19.

Airway PI3K pathway activation is an early and reversible event in lung cancer development.

Gustafson AM, Soldi R, Anderlind C, Scholand MB, Qian J, Zhang X, Cooper K, Walker D, McWilliams A, Liu G, Szabo E, Brody J, Massion PP, Lenburg ME, Lam S, Bild AH, Spira A.

Sci Transl Med. 2010 Apr 7;2(26):26ra25. doi: 10.1126/scitranslmed.3000251.

20.

Role of biomarkers for early detection of lung cancer and chemoprevention.

Hirsch FR, Merrick DT, Franklin WA.

Eur Respir J. 2002 Jun;19(6):1151-8. Review.

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