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Items: 1 to 20 of 109

1.

Hypoxia enhances H2O2-mediated upregulation of hepcidin: Evidence for NOX4-mediated iron regulation.

Silva I, Rausch V, Peccerella T, Millonig G, Seitz HK, Mueller S.

Redox Biol. 2018 Jun;16:1-10. doi: 10.1016/j.redox.2018.02.005. Epub 2018 Feb 12.

2.

Does Hypoxia Cause Carcinogenic Iron Accumulation in Alcoholic Liver Disease (ALD)?

Silva I, Rausch V, Seitz HK, Mueller S.

Cancers (Basel). 2017 Oct 25;9(11). pii: E145. doi: 10.3390/cancers9110145. Review.

3.

Sustained submicromolar H2O2 levels induce hepcidin via signal transducer and activator of transcription 3 (STAT3).

Millonig G, Ganzleben I, Peccerella T, Casanovas G, Brodziak-Jarosz L, Breitkopf-Heinlein K, Dick TP, Seitz HK, Muckenthaler MU, Mueller S.

J Biol Chem. 2012 Oct 26;287(44):37472-82. doi: 10.1074/jbc.M112.358911. Epub 2012 Aug 29.

4.

Hepatic hypoxia-inducible factor-2 down-regulates hepcidin expression in mice through an erythropoietin-mediated increase in erythropoiesis.

Mastrogiannaki M, Matak P, Mathieu JR, Delga S, Mayeux P, Vaulont S, Peyssonnaux C.

Haematologica. 2012 Jun;97(6):827-34. doi: 10.3324/haematol.2011.056119. Epub 2011 Dec 29.

5.

Regulation of type II transmembrane serine proteinase TMPRSS6 by hypoxia-inducible factors: new link between hypoxia signaling and iron homeostasis.

Lakhal S, Schödel J, Townsend AR, Pugh CW, Ratcliffe PJ, Mole DR.

J Biol Chem. 2011 Feb 11;286(6):4090-7. doi: 10.1074/jbc.M110.173096. Epub 2010 Oct 21.

6.

NADPH oxidase 4 deficiency leads to impaired wound repair and reduced dityrosine-crosslinking, but does not affect myofibroblast formation.

Lévigne D, Modarressi A, Krause KH, Pittet-Cuénod B.

Free Radic Biol Med. 2016 Jul;96:374-84. doi: 10.1016/j.freeradbiomed.2016.04.194. Epub 2016 Apr 30.

7.

Ceramide Induces Human Hepcidin Gene Transcription through JAK/STAT3 Pathway.

Lu S, Natarajan SK, Mott JL, Kharbanda KK, Harrison-Findik DD.

PLoS One. 2016 Jan 25;11(1):e0147474. doi: 10.1371/journal.pone.0147474. eCollection 2016.

8.

Hypoxia inhibits hepcidin expression in HuH7 hepatoma cells via decreased SMAD4 signaling.

Chaston TB, Matak P, Pourvali K, Srai SK, McKie AT, Sharp PA.

Am J Physiol Cell Physiol. 2011 Apr;300(4):C888-95. doi: 10.1152/ajpcell.00121.2010. Epub 2011 Feb 2.

9.

Icariin regulates systemic iron metabolism by increasing hepatic hepcidin expression through Stat3 and Smad1/5/8 signaling.

Zhang M, Liu J, Guo W, Liu X, Liu S, Yin H.

Int J Mol Med. 2016 May;37(5):1379-88. doi: 10.3892/ijmm.2016.2545. Epub 2016 Apr 1.

PMID:
27035325
10.

Differential transcriptional regulation of hypoxia-inducible factor-1α by arsenite under normoxia and hypoxia: involvement of Nrf2.

Al Taleb Z, Petry A, Chi TF, Mennerich D, Görlach A, Dimova EY, Kietzmann T.

J Mol Med (Berl). 2016 Oct;94(10):1153-1166. Epub 2016 Jun 10.

11.

Heparanase Overexpression Reduces Hepcidin Expression, Affects Iron Homeostasis and Alters the Response to Inflammation.

Asperti M, Stuemler T, Poli M, Gryzik M, Lifshitz L, Meyron-Holtz EG, Vlodavsky I, Arosio P.

PLoS One. 2016 Oct 6;11(10):e0164183. doi: 10.1371/journal.pone.0164183. eCollection 2016.

12.

Serum-induced up-regulation of hepcidin expression involves the bone morphogenetic protein signaling pathway.

Shanmugam NK, Cherayil BJ.

Biochem Biophys Res Commun. 2013 Nov 15;441(2):383-6. doi: 10.1016/j.bbrc.2013.10.065. Epub 2013 Oct 21.

13.

ROS-induced ROS release orchestrated by Nox4, Nox2, and mitochondria in VEGF signaling and angiogenesis.

Kim YM, Kim SJ, Tatsunami R, Yamamura H, Fukai T, Ushio-Fukai M.

Am J Physiol Cell Physiol. 2017 Jun 1;312(6):C749-C764. doi: 10.1152/ajpcell.00346.2016. Epub 2017 Apr 19.

14.

Contribution of STAT3 and SMAD4 pathways to the regulation of hepcidin by opposing stimuli.

Huang H, Constante M, Layoun A, Santos MM.

Blood. 2009 Apr 9;113(15):3593-9. doi: 10.1182/blood-2008-08-173641. Epub 2009 Feb 9.

15.

A complex signaling network involving protein kinase CK2 is required for hepatitis C virus core protein-mediated modulation of the iron-regulatory hepcidin gene expression.

Foka P, Dimitriadis A, Kyratzopoulou E, Giannimaras DA, Sarno S, Simos G, Georgopoulou U, Mamalaki A.

Cell Mol Life Sci. 2014 Nov;71(21):4243-58. doi: 10.1007/s00018-014-1621-4. Epub 2014 Apr 10.

PMID:
24718935
16.

Peroxisome proliferator-activated receptor gamma depletion stimulates Nox4 expression and human pulmonary artery smooth muscle cell proliferation.

Bijli KM, Kleinhenz JM, Murphy TC, Kang BY, Adesina SE, Sutliff RL, Hart CM.

Free Radic Biol Med. 2015 Mar;80:111-20. doi: 10.1016/j.freeradbiomed.2014.12.019. Epub 2014 Dec 31.

17.

STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation.

Verga Falzacappa MV, Vujic Spasic M, Kessler R, Stolte J, Hentze MW, Muckenthaler MU.

Blood. 2007 Jan 1;109(1):353-8. Epub 2006 Aug 31.

18.

Distinct roles of Nox1 and Nox4 in basal and angiotensin II-stimulated superoxide and hydrogen peroxide production.

Dikalov SI, Dikalova AE, Bikineyeva AT, Schmidt HH, Harrison DG, Griendling KK.

Free Radic Biol Med. 2008 Nov 1;45(9):1340-51. doi: 10.1016/j.freeradbiomed.2008.08.013. Epub 2008 Aug 16.

19.

Hydrogen Sulfide Attenuates Inflammatory Hepcidin by Reducing IL-6 Secretion and Promoting SIRT1-Mediated STAT3 Deacetylation.

Xin H, Wang M, Tang W, Shen Z, Miao L, Wu W, Li C, Wang X, Xin X, Zhu YZ.

Antioxid Redox Signal. 2016 Jan 10;24(2):70-83. doi: 10.1089/ars.2015.6315. Epub 2015 Sep 3.

20.

Iron-regulatory gene expression during liver regeneration.

Mollbrink A, Holmström P, Sjöström M, Hultcrantz R, Eriksson LC, Stål P.

Scand J Gastroenterol. 2012 May;47(5):591-600. doi: 10.3109/00365521.2012.661761. Epub 2012 Feb 27.

PMID:
22364558

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