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Trefoil Factor 2 Promotes Type 2 Immunity and Lung Repair through Intrinsic Roles in Hematopoietic and Nonhematopoietic Cells.

Hung LY, Oniskey TK, Sen D, Krummel MF, Vaughan AE, Cohen NA, Herbert DR.

Am J Pathol. 2018 May;188(5):1161-1170. doi: 10.1016/j.ajpath.2018.01.020. Epub 2018 Feb 16.


Macrophages promote epithelial proliferation following infectious and non-infectious lung injury through a Trefoil factor 2-dependent mechanism.

Hung LY, Sen D, Oniskey TK, Katzen J, Cohen NA, Vaughan AE, Nieves W, Urisman A, Beers MF, Krummel MF, Herbert DR.

Mucosal Immunol. 2019 Jan;12(1):64-76. doi: 10.1038/s41385-018-0096-2. Epub 2018 Oct 18.


Trefoil factor 2 rapidly induces interleukin 33 to promote type 2 immunity during allergic asthma and hookworm infection.

Wills-Karp M, Rani R, Dienger K, Lewkowich I, Fox JG, Perkins C, Lewis L, Finkelman FD, Smith DE, Bryce PJ, Kurt-Jones EA, Wang TC, Sivaprasad U, Hershey GK, Herbert DR.

J Exp Med. 2012 Mar 12;209(3):607-22. doi: 10.1084/jem.20110079. Epub 2012 Feb 13.


TFF2 deficiency exacerbates weight loss and alters immune cell and cytokine profiles in DSS colitis, and this cannot be rescued by wild-type bone marrow.

Judd LM, Chalinor HV, Walduck A, Pavlic DI, Däbritz J, Dubeykovskaya Z, Wang TC, Menheniott TR, Giraud AS.

Am J Physiol Gastrointest Liver Physiol. 2015 Jan 1;308(1):G12-24. doi: 10.1152/ajpgi.00172.2014. Epub 2014 Oct 16.


Lung-resident CD4⁺ T cells are sufficient for IL-4Rα-dependent recall immunity to Nippostrongylus brasiliensis infection.

Thawer SG, Horsnell WG, Darby M, Hoving JC, Dewals B, Cutler AJ, Lang D, Brombacher F.

Mucosal Immunol. 2014 Mar;7(2):239-48. doi: 10.1038/mi.2013.40. Epub 2013 Jun 19.


Surfactant Protein-D Is Essential for Immunity to Helminth Infection.

Thawer S, Auret J, Schnoeller C, Chetty A, Smith K, Darby M, Roberts L, Mackay RM, Whitwell HJ, Timms JF, Madsen J, Selkirk ME, Brombacher F, Clark HW, Horsnell WG.

PLoS Pathog. 2016 Feb 22;12(2):e1005461. doi: 10.1371/journal.ppat.1005461. eCollection 2016 Feb.


Plasmodium chabaudi limits early Nippostrongylus brasiliensis-induced pulmonary immune activation and Th2 polarization in co-infected mice.

Hoeve MA, Mylonas KJ, Fairlie-Clarke KJ, Mahajan SM, Allen JE, Graham AL.

BMC Immunol. 2009 Dec 1;10:60. doi: 10.1186/1471-2172-10-60.


Nippostrongylus brasiliensis: identification of intelectin-1 and -2 as Stat6-dependent genes expressed in lung and intestine during infection.

Voehringer D, Stanley SA, Cox JS, Completo GC, Lowary TL, Locksley RM.

Exp Parasitol. 2007 Aug;116(4):458-66. Epub 2007 Mar 6.


Nippostrongylus brasiliensis infection leads to the development of emphysema associated with the induction of alternatively activated macrophages.

Marsland BJ, Kurrer M, Reissmann R, Harris NL, Kopf M.

Eur J Immunol. 2008 Feb;38(2):479-88. doi: 10.1002/eji.200737827.


γδ T cells play a protective role during infection with Nippostrongylus brasiliensis by promoting goblet cell function in the small intestine.

Inagaki-Ohara K, Sakamoto Y, Dohi T, Smith AL.

Immunology. 2011 Dec;134(4):448-58. doi: 10.1111/j.1365-2567.2011.03503.x.


Protective roles of eosinophils in Nippostrongylus brasiliensis infection.

Shin EH, Osada Y, Chai JY, Matsumoto N, Takatsu K, Kojima S.

Int Arch Allergy Immunol. 1997 Oct;114 Suppl 1:45-50.


Airway trefoil factor expression during naphthalene injury and repair.

Greeley MA, Van Winkle LS, Edwards PC, Plopper CG.

Toxicol Sci. 2010 Feb;113(2):453-67. doi: 10.1093/toxsci/kfp268. Epub 2009 Oct 30.


IL-9-mediated survival of type 2 innate lymphoid cells promotes damage control in helminth-induced lung inflammation.

Turner JE, Morrison PJ, Wilhelm C, Wilson M, Ahlfors H, Renauld JC, Panzer U, Helmby H, Stockinger B.

J Exp Med. 2013 Dec 16;210(13):2951-65. doi: 10.1084/jem.20130071. Epub 2013 Nov 18.


Host- and Helminth-Derived Endocannabinoids That Have Effects on Host Immunity Are Generated during Infection.

Batugedara HM, Argueta D, Jang JC, Lu D, Macchietto M, Kaur J, Ge S, Dillman AR, DiPatrizio NV, Nair MG.

Infect Immun. 2018 Oct 25;86(11). pii: e00441-18. doi: 10.1128/IAI.00441-18. Print 2018 Nov.


Loss of Trefoil Factor 2 From Pancreatic Duct Glands Promotes Formation of Intraductal Papillary Mucinous Neoplasms in Mice.

Yamaguchi J, Mino-Kenudson M, Liss AS, Chowdhury S, Wang TC, Fernández-Del Castillo C, Lillemoe KD, Warshaw AL, Thayer SP.

Gastroenterology. 2016 Dec;151(6):1232-1244.e10. doi: 10.1053/j.gastro.2016.07.045. Epub 2016 Aug 12.


Trefoil factor 2 negatively regulates type 1 immunity against Toxoplasma gondii.

McBerry C, Egan CE, Rani R, Yang Y, Wu D, Boespflug N, Boon L, Butcher B, Mirpuri J, Hogan SP, Denkers EY, Aliberti J, Herbert DR.

J Immunol. 2012 Sep 15;189(6):3078-84. doi: 10.4049/jimmunol.1103374. Epub 2012 Aug 15.


Type 3 muscarinic receptors contribute to intestinal mucosal homeostasis and clearance of Nippostrongylus brasiliensis through induction of TH2 cytokines.

McLean LP, Smith A, Cheung L, Urban JF Jr, Sun R, Grinchuk V, Desai N, Zhao A, Raufman JP, Shea-Donohue T.

Am J Physiol Gastrointest Liver Physiol. 2016 Jul 1;311(1):G130-41. doi: 10.1152/ajpgi.00461.2014. Epub 2016 May 12.


Trefoil factor-2 is an allergen-induced gene regulated by Th2 cytokines and STAT6 in the lung.

Nikolaidis NM, Zimmermann N, King NE, Mishra A, Pope SM, Finkelman FD, Rothenberg ME.

Am J Respir Cell Mol Biol. 2003 Oct;29(4):458-64. Epub 2003 Apr 17.


Ym1 induces RELMα and rescues IL-4Rα deficiency in lung repair during nematode infection.

Sutherland TE, Rückerl D, Logan N, Duncan S, Wynn TA, Allen JE.

PLoS Pathog. 2018 Nov 30;14(11):e1007423. doi: 10.1371/journal.ppat.1007423. eCollection 2018 Nov.

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