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Items: 1 to 20 of 100

1.

Triplications of human chromosome 21 orthologous regions in mice result in expansion of megakaryocyte-erythroid progenitors and reduction of granulocyte-macrophage progenitors.

Liu C, Yu T, Xing Z, Jiang X, Li Y, Pao A, Mu J, Wallace PK, Stoica G, Bakin AV, Yu YE.

Oncotarget. 2017 Dec 19;9(4):4773-4786. doi: 10.18632/oncotarget.23463. eCollection 2018 Jan 12.

2.

Human chromosome 21 orthologous region on mouse chromosome 17 is a major determinant of Down syndrome-related developmental cognitive deficits.

Zhang L, Meng K, Jiang X, Liu C, Pao A, Belichenko PV, Kleschevnikov AM, Josselyn S, Liang P, Ye P, Mobley WC, Yu YE.

Hum Mol Genet. 2014 Feb 1;23(3):578-89. doi: 10.1093/hmg/ddt446. Epub 2013 Sep 16.

3.

Effects of individual segmental trisomies of human chromosome 21 syntenic regions on hippocampal long-term potentiation and cognitive behaviors in mice.

Yu T, Liu C, Belichenko P, Clapcote SJ, Li S, Pao A, Kleschevnikov A, Bechard AR, Asrar S, Chen R, Fan N, Zhou Z, Jia Z, Chen C, Roder JC, Liu B, Baldini A, Mobley WC, Yu YE.

Brain Res. 2010 Dec 17;1366:162-71. doi: 10.1016/j.brainres.2010.09.107. Epub 2010 Oct 26.

4.

Genetic analysis of Down syndrome-associated heart defects in mice.

Liu C, Morishima M, Yu T, Matsui S, Zhang L, Fu D, Pao A, Costa AC, Gardiner KJ, Cowell JK, Nowak NJ, Parmacek MS, Liang P, Baldini A, Yu YE.

Hum Genet. 2011 Nov;130(5):623-32. doi: 10.1007/s00439-011-0980-2. Epub 2011 Mar 26. Erratum in: Hum Genet. 2011 Nov;130(5):633. Nowak, Normal J [corrected to Nowak, Norma J].

5.

Engineered chromosome-based genetic mapping establishes a 3.7 Mb critical genomic region for Down syndrome-associated heart defects in mice.

Liu C, Morishima M, Jiang X, Yu T, Meng K, Ray D, Pao A, Ye P, Parmacek MS, Yu YE.

Hum Genet. 2014 Jun;133(6):743-53. doi: 10.1007/s00439-013-1407-z. Epub 2013 Dec 22.

6.

Perturbation of fetal hematopoiesis in a mouse model of Down syndrome's transient myeloproliferative disorder.

Birger Y, Goldberg L, Chlon TM, Goldenson B, Muler I, Schiby G, Jacob-Hirsch J, Rechavi G, Crispino JD, Izraeli S.

Blood. 2013 Aug 8;122(6):988-98. doi: 10.1182/blood-2012-10-460998. Epub 2013 May 29.

7.

Perturbed hematopoiesis in the Tc1 mouse model of Down syndrome.

Alford KA, Slender A, Vanes L, Li Z, Fisher EM, Nizetic D, Orkin SH, Roberts I, Tybulewicz VL.

Blood. 2010 Apr 8;115(14):2928-37. doi: 10.1182/blood-2009-06-227629. Epub 2010 Feb 12.

8.

Genetic dissection of the Down syndrome critical region.

Jiang X, Liu C, Yu T, Zhang L, Meng K, Xing Z, Belichenko PV, Kleschevnikov AM, Pao A, Peresie J, Wie S, Mobley WC, Yu YE.

Hum Mol Genet. 2015 Nov 15;24(22):6540-51. doi: 10.1093/hmg/ddv364. Epub 2015 Sep 15.

9.

Mouse models of Down syndrome: gene content and consequences.

Gupta M, Dhanasekaran AR, Gardiner KJ.

Mamm Genome. 2016 Dec;27(11-12):538-555. Epub 2016 Aug 18. Review.

10.

miR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukemia.

Klusmann JH, Li Z, Böhmer K, Maroz A, Koch ML, Emmrich S, Godinho FJ, Orkin SH, Reinhardt D.

Genes Dev. 2010 Mar 1;24(5):478-90. doi: 10.1101/gad.1856210.

11.

Surveying the Down syndrome mouse model resource identifies critical regions responsible for chronic otitis media.

Bhutta MF, Cheeseman MT, Herault Y, Yu YE, Brown SD.

Mamm Genome. 2013 Dec;24(11-12):439-45. doi: 10.1007/s00335-013-9475-x. Epub 2013 Sep 26.

12.

Overlapping trisomies for human chromosome 21 orthologs produce similar effects on skull and brain morphology of Dp(16)1Yey and Ts65Dn mice.

Starbuck JM, Dutka T, Ratliff TS, Reeves RH, Richtsmeier JT.

Am J Med Genet A. 2014 Aug;164A(8):1981-1990. doi: 10.1002/ajmg.a.36594. Epub 2014 May 1.

13.

The genetic background and application of Down syndrome mouse models.

Meng XW, Wang J, Ma QW.

Yi Chuan. 2018 Mar 20;40(3):207-217. doi: 10.16288/j.yczz.17-279. Review.

PMID:
29576544
14.

Abnormalities in the myeloid progenitor compartment in Down syndrome fetal liver precede acquisition of GATA1 mutations.

Tunstall-Pedoe O, Roy A, Karadimitris A, de la Fuente J, Fisk NM, Bennett P, Norton A, Vyas P, Roberts I.

Blood. 2008 Dec 1;112(12):4507-11. doi: 10.1182/blood-2008-04-152967. Epub 2008 Aug 8.

PMID:
18689547
15.

A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions.

Yu T, Li Z, Jia Z, Clapcote SJ, Liu C, Li S, Asrar S, Pao A, Chen R, Fan N, Carattini-Rivera S, Bechard AR, Spring S, Henkelman RM, Stoica G, Matsui S, Nowak NJ, Roder JC, Chen C, Bradley A, Yu YE.

Hum Mol Genet. 2010 Jul 15;19(14):2780-91. doi: 10.1093/hmg/ddq179. Epub 2010 May 4.

16.

Early lineage priming by trisomy of Erg leads to myeloproliferation in a Down syndrome model.

Ng AP, Hu Y, Metcalf D, Hyland CD, Ierino H, Phipson B, Wu D, Baldwin TM, Kauppi M, Kiu H, Di Rago L, Hilton DJ, Smyth GK, Alexander WS.

PLoS Genet. 2015 May 14;11(5):e1005211. doi: 10.1371/journal.pgen.1005211. eCollection 2015 May.

17.

Increased dosage of the chromosome 21 ortholog Dyrk1a promotes megakaryoblastic leukemia in a murine model of Down syndrome.

Malinge S, Bliss-Moreau M, Kirsammer G, Diebold L, Chlon T, Gurbuxani S, Crispino JD.

J Clin Invest. 2012 Mar;122(3):948-62. doi: 10.1172/JCI60455. Epub 2012 Feb 22.

18.

Sex differences in protein expression in the mouse brain and their perturbations in a model of Down syndrome.

Block A, Ahmed MM, Dhanasekaran AR, Tong S, Gardiner KJ.

Biol Sex Differ. 2015 Nov 9;6:24. doi: 10.1186/s13293-015-0043-9. eCollection 2015.

19.

Highly penetrant myeloproliferative disease in the Ts65Dn mouse model of Down syndrome.

Kirsammer G, Jilani S, Liu H, Davis E, Gurbuxani S, Le Beau MM, Crispino JD.

Blood. 2008 Jan 15;111(2):767-75. Epub 2007 Sep 27.

20.

Pluripotent stem cells reveal erythroid-specific activities of the GATA1 N-terminus.

Byrska-Bishop M, VanDorn D, Campbell AE, Betensky M, Arca PR, Yao Y, Gadue P, Costa FF, Nemiroff RL, Blobel GA, French DL, Hardison RC, Weiss MJ, Chou ST.

J Clin Invest. 2015 Mar 2;125(3):993-1005. doi: 10.1172/JCI75714. Epub 2015 Jan 26.

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