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Items: 1 to 20 of 99

1.

Epigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood.

Yuan X, Tsujimoto K, Hashimoto K, Kawahori K, Hanzawa N, Hamaguchi M, Seki T, Nawa M, Ehara T, Kitamura Y, Hatada I, Konishi M, Itoh N, Nakagawa Y, Shimano H, Takai-Igarashi T, Kamei Y, Ogawa Y.

Nat Commun. 2018 Feb 12;9(1):636. doi: 10.1038/s41467-018-03038-w.

2.

Hepatic Aryl Hydrocarbon Receptor Attenuates Fibroblast Growth Factor 21 Expression.

Girer NG, Murray IA, Omiecinski CJ, Perdew GH.

J Biol Chem. 2016 Jul 15;291(29):15378-87. doi: 10.1074/jbc.M116.715151. Epub 2016 May 25.

3.

Activation of the farnesoid X receptor induces hepatic expression and secretion of fibroblast growth factor 21.

Cyphert HA, Ge X, Kohan AB, Salati LM, Zhang Y, Hillgartner FB.

J Biol Chem. 2012 Jul 20;287(30):25123-38. doi: 10.1074/jbc.M112.375907. Epub 2012 Jun 1.

4.

PPARalpha is a key regulator of hepatic FGF21.

Lundåsen T, Hunt MC, Nilsson LM, Sanyal S, Angelin B, Alexson SE, Rudling M.

Biochem Biophys Res Commun. 2007 Aug 24;360(2):437-40. Epub 2007 Jun 21.

PMID:
17601491
5.

Liver-enriched transcription factor CREBH interacts with peroxisome proliferator-activated receptor α to regulate metabolic hormone FGF21.

Kim H, Mendez R, Zheng Z, Chang L, Cai J, Zhang R, Zhang K.

Endocrinology. 2014 Mar;155(3):769-82. doi: 10.1210/en.2013-1490. Epub 2014 Jan 1.

6.

The hepatokine FGF21 is crucial for peroxisome proliferator-activated receptor-α agonist-induced amelioration of metabolic disorders in obese mice.

Goto T, Hirata M, Aoki Y, Iwase M, Takahashi H, Kim M, Li Y, Jheng HF, Nomura W, Takahashi N, Kim CS, Yu R, Seno S, Matsuda H, Aizawa-Abe M, Ebihara K, Itoh N, Kawada T.

J Biol Chem. 2017 Jun 2;292(22):9175-9190. doi: 10.1074/jbc.M116.767590. Epub 2017 Apr 12.

7.

Diet Polyphenol Curcumin Stimulates Hepatic Fgf21 Production and Restores Its Sensitivity in High-Fat-Diet-Fed Male Mice.

Zeng K, Tian L, Patel R, Shao W, Song Z, Liu L, Manuel J, Ma X, McGilvray I, Cummins CL, Weng J, Jin T.

Endocrinology. 2017 Feb 1;158(2):277-292. doi: 10.1210/en.2016-1596. Erratum in: Endocrinology. 2017 Jun 1;158(6):2012.

PMID:
27967217
8.

The PPARα-FGF21 hormone axis contributes to metabolic regulation by the hepatic JNK signaling pathway.

Vernia S, Cavanagh-Kyros J, Garcia-Haro L, Sabio G, Barrett T, Jung DY, Kim JK, Xu J, Shulha HP, Garber M, Gao G, Davis RJ.

Cell Metab. 2014 Sep 2;20(3):512-25. doi: 10.1016/j.cmet.2014.06.010. Epub 2014 Jul 17.

9.

Circadian expression of FGF21 is induced by PPARalpha activation in the mouse liver.

Oishi K, Uchida D, Ishida N.

FEBS Lett. 2008 Oct 29;582(25-26):3639-42. doi: 10.1016/j.febslet.2008.09.046. Epub 2008 Oct 7.

10.

Upregulation of rat liver PPARα-FGF21 signaling by a docosahexaenoic acid and thyroid hormone combined protocol.

Videla LA, Fernández V, Vargas R, Cornejo P, Tapia G, Varela N, Valenzuela R, Arenas A, Fernández J, Hernández-Rodas MC, Riquelme B.

Biofactors. 2016 Nov 12;42(6):638-646. doi: 10.1002/biof.1300. Epub 2016 Jun 1.

PMID:
27248050
11.

Sodium butyrate stimulates expression of fibroblast growth factor 21 in liver by inhibition of histone deacetylase 3.

Li H, Gao Z, Zhang J, Ye X, Xu A, Ye J, Jia W.

Diabetes. 2012 Apr;61(4):797-806. doi: 10.2337/db11-0846. Epub 2012 Feb 14.

12.

Hepatic FGF21 expression is induced at birth via PPARalpha in response to milk intake and contributes to thermogenic activation of neonatal brown fat.

Hondares E, Rosell M, Gonzalez FJ, Giralt M, Iglesias R, Villarroya F.

Cell Metab. 2010 Mar 3;11(3):206-12. doi: 10.1016/j.cmet.2010.02.001.

13.

Single ingestion of soy β-conglycinin induces increased postprandial circulating FGF21 levels exerting beneficial health effects.

Hashidume T, Kato A, Tanaka T, Miyoshi S, Itoh N, Nakata R, Inoue H, Oikawa A, Nakai Y, Shimizu M, Inoue J, Sato R.

Sci Rep. 2016 Jun 17;6:28183. doi: 10.1038/srep28183.

14.

Conjugated linoleic acid induces hepatic expression of fibroblast growth factor 21 through PPAR-α.

Yu J, Yu B, Jiang H, Chen D.

Br J Nutr. 2012 Feb;107(4):461-5. doi: 10.1017/S0007114511003205. Epub 2011 Jul 18.

PMID:
21767451
15.

Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21.

Li Y, Wong K, Giles A, Jiang J, Lee JW, Adams AC, Kharitonenkov A, Yang Q, Gao B, Guarente L, Zang M.

Gastroenterology. 2014 Feb;146(2):539-49.e7. doi: 10.1053/j.gastro.2013.10.059. Epub 2013 Nov 1.

16.

A Specific ChREBP and PPARα Cross-Talk Is Required for the Glucose-Mediated FGF21 Response.

Iroz A, Montagner A, Benhamed F, Levavasseur F, Polizzi A, Anthony E, Régnier M, Fouché E, Lukowicz C, Cauzac M, Tournier E, Do-Cruzeiro M, Daujat-Chavanieu M, Gerbal-Chalouin S, Fauveau V, Marmier S, Burnol AF, Guilmeau S, Lippi Y, Girard J, Wahli W, Dentin R, Guillou H, Postic C.

Cell Rep. 2017 Oct 10;21(2):403-416. doi: 10.1016/j.celrep.2017.09.065.

17.

Thyroid hormone regulates hepatic expression of fibroblast growth factor 21 in a PPARalpha-dependent manner.

Adams AC, Astapova I, Fisher FM, Badman MK, Kurgansky KE, Flier JS, Hollenberg AN, Maratos-Flier E.

J Biol Chem. 2010 May 7;285(19):14078-82. doi: 10.1074/jbc.C110.107375. Epub 2010 Mar 17.

18.

Glucagon and lipid interactions in the regulation of hepatic AMPK signaling and expression of PPARalpha and FGF21 transcripts in vivo.

Berglund ED, Kang L, Lee-Young RS, Hasenour CM, Lustig DG, Lynes SE, Donahue EP, Swift LL, Charron MJ, Wasserman DH.

Am J Physiol Endocrinol Metab. 2010 Oct;299(4):E607-14. doi: 10.1152/ajpendo.00263.2010. Epub 2010 Jul 27. Retraction in: Am J Physiol Endocrinol Metab. 2016 Nov 1;311(5):E850.

19.

FGF21 Is Not a Major Mediator for Bone Homeostasis or Metabolic Actions of PPARα and PPARγ Agonists.

Li X, Stanislaus S, Asuncion F, Niu QT, Chinookoswong N, Villasenor K, Wang J, Wong P, Boyce R, Dwyer D, Han CY, Chen MM, Liu B, Stolina M, Ke HZ, Ominsky MS, Véniant MM, Xu J.

J Bone Miner Res. 2017 Apr;32(4):834-845. doi: 10.1002/jbmr.2936. Epub 2016 Sep 9.

20.

Orphan nuclear receptor Nur77 mediates fasting-induced hepatic fibroblast growth factor 21 expression.

Min AK, Bae KH, Jung YA, Choi YK, Kim MJ, Kim JH, Jeon JH, Kim JG, Lee IK, Park KG.

Endocrinology. 2014 Aug;155(8):2924-31. doi: 10.1210/en.2013-1758. Epub 2014 Jun 2. Erratum in: Endocrinology. 2015 Jan;156(1):406.

PMID:
24885573

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