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The Chlamydia pneumoniae Tarp Ortholog CPn0572 Stabilizes Host F-Actin by Displacement of Cofilin.

Zrieq R, Braun C, Hegemann JH.

Front Cell Infect Microbiol. 2017 Dec 12;7:511. doi: 10.3389/fcimb.2017.00511. eCollection 2017.


CPn0572, the C. pneumoniae ortholog of TarP, reorganizes the actin cytoskeleton via a newly identified F-actin binding domain and recruitment of vinculin.

Braun C, Alcázar-Román AR, Laska A, Mölleken K, Fleig U, Hegemann JH.

PLoS One. 2019 Jan 10;14(1):e0210403. doi: 10.1371/journal.pone.0210403. eCollection 2019.


Chlamydia trachomatis Tarp harbors distinct G and F actin binding domains that bundle actin filaments.

Jiwani S, Alvarado S, Ohr RJ, Romero A, Nguyen B, Jewett TJ.

J Bacteriol. 2013 Feb;195(4):708-16. doi: 10.1128/JB.01768-12. Epub 2012 Nov 30.


Tyrosine phosphorylation of the chlamydial effector protein Tarp is species specific and not required for recruitment of actin.

Clifton DR, Dooley CA, Grieshaber SS, Carabeo RA, Fields KA, Hackstadt T.

Infect Immun. 2005 Jul;73(7):3860-8.


Chlamydial TARP is a bacterial nucleator of actin.

Jewett TJ, Fischer ER, Mead DJ, Hackstadt T.

Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15599-604. Epub 2006 Oct 6.


Targeted Disruption of Chlamydia trachomatis Invasion by in Trans Expression of Dominant Negative Tarp Effectors.

Parrett CJ, Lenoci RV, Nguyen B, Russell L, Jewett TJ.

Front Cell Infect Microbiol. 2016 Aug 23;6:84. doi: 10.3389/fcimb.2016.00084. eCollection 2016.


Severing of F-actin by yeast cofilin is pH-independent.

Pavlov D, Muhlrad A, Cooper J, Wear M, Reisler E.

Cell Motil Cytoskeleton. 2006 Sep;63(9):533-42.


Chlamydia trachomatis Tarp cooperates with the Arp2/3 complex to increase the rate of actin polymerization.

Jiwani S, Ohr RJ, Fischer ER, Hackstadt T, Alvarado S, Romero A, Jewett TJ.

Biochem Biophys Res Commun. 2012 Apr 20;420(4):816-21. doi: 10.1016/j.bbrc.2012.03.080. Epub 2012 Mar 23.


Actin filament severing by cofilin dismantles actin patches and produces mother filaments for new patches.

Chen Q, Pollard TD.

Curr Biol. 2013 Jul 8;23(13):1154-62. doi: 10.1016/j.cub.2013.05.005. Epub 2013 May 30.


The conserved Tarp actin binding domain is important for chlamydial invasion.

Jewett TJ, Miller NJ, Dooley CA, Hackstadt T.

PLoS Pathog. 2010 Jul 15;6(7):e1000997. doi: 10.1371/journal.ppat.1000997.


Control of actin turnover by a salmonella invasion protein.

McGhie EJ, Hayward RD, Koronakis V.

Mol Cell. 2004 Feb 27;13(4):497-510.


Helical rotation of the diaphanous-related formin mDia1 generates actin filaments resistant to cofilin.

Mizuno H, Tanaka K, Yamashiro S, Narita A, Watanabe N.

Proc Natl Acad Sci U S A. 2018 May 29;115(22):E5000-E5007. doi: 10.1073/pnas.1803415115. Epub 2018 May 14.


Vinculin Interacts with the Chlamydia Effector TarP Via a Tripartite Vinculin Binding Domain to Mediate Actin Recruitment and Assembly at the Plasma Membrane.

Thwaites TR, Pedrosa AT, Peacock TP, Carabeo RA.

Front Cell Infect Microbiol. 2015 Nov 30;5:88. doi: 10.3389/fcimb.2015.00088. eCollection 2015.


Srv2/CAP is required for polarized actin cable assembly and patch internalization during clathrin-mediated endocytosis.

Toshima JY, Horikomi C, Okada A, Hatori MN, Nagano M, Masuda A, Yamamoto W, Siekhaus DE, Toshima J.

J Cell Sci. 2016 Jan 15;129(2):367-79. doi: 10.1242/jcs.176651. Epub 2015 Nov 24.


Biophysical characterization of actin bundles generated by the Chlamydia trachomatis Tarp effector.

Ghosh S, Park J, Thomas M, Cruz E, Cardona O, Kang H, Jewett T.

Biochem Biophys Res Commun. 2018 Jun 2;500(2):423-428. doi: 10.1016/j.bbrc.2018.04.093. Epub 2018 Apr 17.


Aip1p interacts with cofilin to disassemble actin filaments.

Rodal AA, Tetreault JW, Lappalainen P, Drubin DG, Amberg DC.

J Cell Biol. 1999 Jun 14;145(6):1251-64.


Cofilin cross-bridges adjacent actin protomers and replaces part of the longitudinal F-actin interface.

Kudryashov DS, Galkin VE, Orlova A, Phan M, Egelman EH, Reisler E.

J Mol Biol. 2006 May 5;358(3):785-97. Epub 2006 Feb 28.


Rapid nucleotide exchange renders Asp-11 mutant actins resistant to depolymerizing activity of cofilin, leading to dominant toxicity in vivo.

Umeki N, Nakajima J, Noguchi TQ, Tokuraku K, Nagasaki A, Ito K, Hirose K, Uyeda TQ.

J Biol Chem. 2013 Jan 18;288(3):1739-49. doi: 10.1074/jbc.M112.404657. Epub 2012 Dec 3.


Aip1 promotes actin filament severing by cofilin and regulates constriction of the cytokinetic contractile ring.

Chen Q, Courtemanche N, Pollard TD.

J Biol Chem. 2015 Jan 23;290(4):2289-300. doi: 10.1074/jbc.M114.612978. Epub 2014 Dec 1.


Drebrin inhibits cofilin-induced severing of F-actin.

Grintsevich EE, Reisler E.

Cytoskeleton (Hoboken). 2014 Aug;71(8):472-83. doi: 10.1002/cm.21184. Epub 2014 Aug 18.

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