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A purified, fermented, extract of Triticum aestivum has lymphomacidal activity mediated via natural killer cell activation.

Barisone GA, O'Donnell RT, Ma Y, Abuhay MW, Lundeberg K, Gowda S, Tuscano JM.

PLoS One. 2018 Jan 5;13(1):e0190860. doi: 10.1371/journal.pone.0190860. eCollection 2018.


[Fermented wheat germ extract in the supportive therapy of colorectal cancer].

Farkas E.

Orv Hetil. 2005 Sep 11;146(37):1925-31. Hungarian.


Antitumor Activities and Apoptosis-regulated Mechanisms of Fermented Wheat Germ Extract in the Transplantation Tumor Model of Human HT-29 Cells in Nude Mice.

Zhang JY, Xiao X, Dong Y, Wu J, Zhou XH.

Biomed Environ Sci. 2015 Oct;28(10):718-27. doi: 10.3967/bes2015.102.


Cooperation of the proapoptotic receptor agonist rhApo2L/TRAIL with the CD20 antibody rituximab against non-Hodgkin lymphoma xenografts.

Daniel D, Yang B, Lawrence DA, Totpal K, Balter I, Lee WP, Gogineni A, Cole MJ, Yee SF, Ross S, Ashkenazi A.

Blood. 2007 Dec 1;110(12):4037-46. Epub 2007 Aug 27.


Treatment of non-Hodgkin's lymphoma xenografts with the HB22.7 anti-CD22 monoclonal antibody and phosphatase inhibitors improves efficacy.

O'Donnell RT, Pearson D, McKnight HC, Ma YP, Tuscano JM.

Cancer Immunol Immunother. 2009 Oct;58(10):1715-22. doi: 10.1007/s00262-009-0688-5. Epub 2009 Mar 18.


Distinct apoptotic signaling characteristics of the anti-CD40 monoclonal antibody dacetuzumab and rituximab produce enhanced antitumor activity in non-Hodgkin lymphoma.

Lewis TS, McCormick RS, Emmerton K, Lau JT, Yu SF, McEarchern JA, Grewal IS, Law CL.

Clin Cancer Res. 2011 Jul 15;17(14):4672-81. doi: 10.1158/1078-0432.CCR-11-0479. Epub 2011 May 24.


The Effects of Adjuvant Fermented Wheat Germ Extract on Cancer Cell Lines: A Systematic Review.

Zhurakivska K, Troiano G, Caponio VCA, Dioguardi M, Arena C, Lo Muzio L.

Nutrients. 2018 Oct 19;10(10). pii: E1546. doi: 10.3390/nu10101546.


A new extract of the plant Calendula officinalis produces a dual in vitro effect: cytotoxic anti-tumor activity and lymphocyte activation.

Jiménez-Medina E, Garcia-Lora A, Paco L, Algarra I, Collado A, Garrido F.

BMC Cancer. 2006 May 5;6:119.


The HB22.7 Anti-CD22 monoclonal antibody enhances bortezomib-mediated lymphomacidal activity in a sequence dependent manner.

Martin SM, Churchill E, McKnight H, Mahaffey CM, Ma Y, O'Donnell RT, Tuscano JM.

J Hematol Oncol. 2011 Dec 1;4:49. doi: 10.1186/1756-8722-4-49.


Recombinant interleukin-2 significantly augments activity of rituximab in human tumor xenograft models of B-cell non-Hodgkin lymphoma.

Lopes de Menezes DE, Denis-Mize K, Tang Y, Ye H, Kunich JC, Garrett EN, Peng J, Cousens LS, Gelb AB, Heise C, Wilson SE, Jallal B, Aukerman SL.

J Immunother. 2007 Jan;30(1):64-74.


Fermented wheat germ extract inhibits glycolysis/pentose cycle enzymes and induces apoptosis through poly(ADP-ribose) polymerase activation in Jurkat T-cell leukemia tumor cells.

Comin-Anduix B, Boros LG, Marin S, Boren J, Callol-Massot C, Centelles JJ, Torres JL, Agell N, Bassilian S, Cascante M.

J Biol Chem. 2002 Nov 29;277(48):46408-14. Epub 2002 Sep 25.


The IL-15-Based ALT-803 Complex Enhances FcγRIIIa-Triggered NK Cell Responses and In Vivo Clearance of B Cell Lymphomas.

Rosario M, Liu B, Kong L, Collins LI, Schneider SE, Chen X, Han K, Jeng EK, Rhode PR, Leong JW, Schappe T, Jewell BA, Keppel CR, Shah K, Hess B, Romee R, Piwnica-Worms DR, Cashen AF, Bartlett NL, Wong HC, Fehniger TA.

Clin Cancer Res. 2016 Feb 1;22(3):596-608. doi: 10.1158/1078-0432.CCR-15-1419. Epub 2015 Sep 30.


Targeting the CD20 and CXCR4 pathways in non-hodgkin lymphoma with rituximab and high-affinity CXCR4 antagonist BKT140.

Beider K, Ribakovsky E, Abraham M, Wald H, Weiss L, Rosenberg E, Galun E, Avigdor A, Eizenberg O, Peled A, Nagler A.

Clin Cancer Res. 2013 Jul 1;19(13):3495-507. doi: 10.1158/1078-0432.CCR-12-3015. Epub 2013 May 1.


Immunomodulatory drugs Revlimid (lenalidomide) and CC-4047 induce apoptosis of both hematological and solid tumor cells through NK cell activation.

Zhu D, Corral LG, Fleming YW, Stein B.

Cancer Immunol Immunother. 2008 Dec;57(12):1849-59. doi: 10.1007/s00262-008-0512-7. Epub 2008 Apr 8.


Fermented wheat germ extract induces apoptosis and downregulation of major histocompatibility complex class I proteins in tumor T and B cell lines.

Fajka-Boja R, Hidvégi M, Shoenfeld Y, Ion G, Demydenko D, Tömösközi-Farkas R, Vizler C, Telekes A, Resetar A, Monostori E.

Int J Oncol. 2002 Mar;20(3):563-70.


Potent in vitro and in vivo activity of an Fc-engineered humanized anti-HM1.24 antibody against multiple myeloma via augmented effector function.

Tai YT, Horton HM, Kong SY, Pong E, Chen H, Cemerski S, Bernett MJ, Nguyen DH, Karki S, Chu SY, Lazar GA, Munshi NC, Desjarlais JR, Anderson KC, Muchhal US.

Blood. 2012 Mar 1;119(9):2074-82. doi: 10.1182/blood-2011-06-364521. Epub 2012 Jan 13.


Anti-cancer activity of Angelica gigas by increasing immune response and stimulating natural killer and natural killer T cells.

Kim SH, Lee SW, Park HJ, Lee SH, Im WK, Kim YD, Kim KH, Park SJ, Hong S, Jeon SH.

BMC Complement Altern Med. 2018 Jul 18;18(1):218. doi: 10.1186/s12906-018-2277-7.


Wheat germ extract decreases glucose uptake and RNA ribose formation but increases fatty acid synthesis in MIA pancreatic adenocarcinoma cells.

Boros LG, Lapis K, Szende B, Tömösközi-Farkas R, Balogh A, Boren J, Marin S, Cascante M, Hidvégi M.

Pancreas. 2001 Aug;23(2):141-7.


Antiproliferative and antimetabolic effects behind the anticancer property of fermented wheat germ extract.

Otto C, Hahlbrock T, Eich K, Karaaslan F, Jürgens C, Germer CT, Wiegering A, Kämmerer U.

BMC Complement Altern Med. 2016 Jun 1;16:160. doi: 10.1186/s12906-016-1138-5.


Effect of fermented wheat germ extract with lactobacillus plantarum dy-1 on HT-29 cell proliferation and apoptosis.

Zhang JY, Xiao X, Dong Y, Wu J, Yao F, Zhou XH.

J Agric Food Chem. 2015 Mar 11;63(9):2449-57. doi: 10.1021/acs.jafc.5b00041. Epub 2015 Mar 2.


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