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Items: 1 to 20 of 103

1.

Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein.

Al-Ramahi I, Giridharan SSP, Chen YC, Patnaik S, Safren N, Hasegawa J, de Haro M, Wagner Gee AK, Titus SA, Jeong H, Clarke J, Krainc D, Zheng W, Irvine RF, Barmada S, Ferrer M, Southall N, Weisman LS, Botas J, Marugan JJ.

Elife. 2017 Dec 26;6. pii: e29123. doi: 10.7554/eLife.29123.

2.

Preventing mutant huntingtin proteolysis and intermittent fasting promote autophagy in models of Huntington disease.

Ehrnhoefer DE, Martin DDO, Schmidt ME, Qiu X, Ladha S, Caron NS, Skotte NH, Nguyen YTN, Vaid K, Southwell AL, Engemann S, Franciosi S, Hayden MR.

Acta Neuropathol Commun. 2018 Mar 6;6(1):16. doi: 10.1186/s40478-018-0518-0.

3.

A toxic mutant huntingtin species is resistant to selective autophagy.

Fu Y, Wu P, Pan Y, Sun X, Yang H, Difiglia M, Lu B.

Nat Chem Biol. 2017 Nov;13(11):1152-1154. doi: 10.1038/nchembio.2461. Epub 2017 Sep 4.

PMID:
28869595
4.

HIPK3 modulates autophagy and HTT protein levels in neuronal and mouse models of Huntington disease.

Fu Y, Sun X, Lu B.

Autophagy. 2018;14(1):169-170. doi: 10.1080/15548627.2017.1393130. Epub 2018 Jan 29.

5.

Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease.

Lu XH, Mattis VB, Wang N, Al-Ramahi I, van den Berg N, Fratantoni SA, Waldvogel H, Greiner E, Osmand A, Elzein K, Xiao J, Dijkstra S, de Pril R, Vinters HV, Faull R, Signer E, Kwak S, Marugan JJ, Botas J, Fischer DF, Svendsen CN, Munoz-Sanjuan I, Yang XW.

Sci Transl Med. 2014 Dec 24;6(268):268ra178. doi: 10.1126/scitranslmed.3010523.

PMID:
25540325
6.

Compartment-Dependent Degradation of Mutant Huntingtin Accounts for Its Preferential Accumulation in Neuronal Processes.

Zhao T, Hong Y, Li S, Li XJ.

J Neurosci. 2016 Aug 10;36(32):8317-28. doi: 10.1523/JNEUROSCI.0806-16.2016.

7.

mGluR5 antagonism increases autophagy and prevents disease progression in the zQ175 mouse model of Huntington's disease.

Abd-Elrahman KS, Hamilton A, Hutchinson SR, Liu F, Russell RC, Ferguson SSG.

Sci Signal. 2017 Dec 19;10(510). pii: eaan6387. doi: 10.1126/scisignal.aan6387.

PMID:
29259100
8.
9.

MicroRNA-27a reduces mutant hutingtin aggregation in an in vitro model of Huntington's disease.

Ban JJ, Chung JY, Lee M, Im W, Kim M.

Biochem Biophys Res Commun. 2017 Jun 24;488(2):316-321. doi: 10.1016/j.bbrc.2017.05.040. Epub 2017 May 8.

PMID:
28495533
10.

Neuronal targets for reducing mutant huntingtin expression to ameliorate disease in a mouse model of Huntington's disease.

Wang N, Gray M, Lu XH, Cantle JP, Holley SM, Greiner E, Gu X, Shirasaki D, Cepeda C, Li Y, Dong H, Levine MS, Yang XW.

Nat Med. 2014 May;20(5):536-41. doi: 10.1038/nm.3514. Epub 2014 Apr 28.

11.

Genetic manipulations of mutant huntingtin in mice: new insights into Huntington's disease pathogenesis.

Lee CY, Cantle JP, Yang XW.

FEBS J. 2013 Sep;280(18):4382-94. doi: 10.1111/febs.12418. Epub 2013 Jul 31. Review.

12.

Sulforaphane enhances proteasomal and autophagic activities in mice and is a potential therapeutic reagent for Huntington's disease.

Liu Y, Hettinger CL, Zhang D, Rezvani K, Wang X, Wang H.

J Neurochem. 2014 May;129(3):539-47. doi: 10.1111/jnc.12647. Epub 2014 Jan 18.

13.
14.

Mutant huntingtin and glycogen synthase kinase 3-beta accumulate in neuronal lipid rafts of a presymptomatic knock-in mouse model of Huntington's disease.

Valencia A, Reeves PB, Sapp E, Li X, Alexander J, Kegel KB, Chase K, Aronin N, DiFiglia M.

J Neurosci Res. 2010 Jan;88(1):179-90. doi: 10.1002/jnr.22184.

PMID:
19642201
15.

IRE1 plays an essential role in ER stress-mediated aggregation of mutant huntingtin via the inhibition of autophagy flux.

Lee H, Noh JY, Oh Y, Kim Y, Chang JW, Chung CW, Lee ST, Kim M, Ryu H, Jung YK.

Hum Mol Genet. 2012 Jan 1;21(1):101-14. doi: 10.1093/hmg/ddr445. Epub 2011 Sep 27.

PMID:
21954231
16.

Formation of hippocampal mHTT aggregates leads to impaired spatial memory, hippocampal activation and adult neurogenesis.

Schwab LC, Richetin K, Barker RA, Déglon N.

Neurobiol Dis. 2017 Jun;102:105-112. doi: 10.1016/j.nbd.2017.03.005. Epub 2017 Mar 9.

PMID:
28286179
17.

Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington's disease.

Aron R, Pellegrini P, Green EW, Maddison DC, Opoku-Nsiah K, Wong JS, Daub AC, Giorgini F, Finkbeiner S.

Nat Commun. 2018 Sep 28;9(1):3191. doi: 10.1038/s41467-018-05653-z. Erratum in: Nat Commun. 2018 Oct 15;9(1):4333.

18.

Huntingtin aggregation kinetics and their pathological role in a Drosophila Huntington's disease model.

Weiss KR, Kimura Y, Lee WC, Littleton JT.

Genetics. 2012 Feb;190(2):581-600. doi: 10.1534/genetics.111.133710. Epub 2011 Nov 17.

19.
20.

Nonmammalian Models of Huntington's Disease.

Chongtham A, Barbaro B, Filip T, Syed A, Huang W, Smith MR, Marsh JL.

Methods Mol Biol. 2018;1780:75-96. doi: 10.1007/978-1-4939-7825-0_5.

PMID:
29856015

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