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Items: 1 to 20 of 122

1.

Mitochondrial and glycolytic metabolic compartmentalization in diffuse large B-cell lymphoma.

Gooptu M, Whitaker-Menezes D, Sprandio J, Domingo-Vidal M, Lin Z, Uppal G, Gong J, Fratamico R, Leiby B, Dulau-Florea A, Caro J, Martinez-Outschoorn U.

Semin Oncol. 2017 Jun;44(3):204-217. doi: 10.1053/j.seminoncol.2017.10.002. Epub 2017 Oct 10.

2.

Hodgkin lymphoma: A complex metabolic ecosystem with glycolytic reprogramming of the tumor microenvironment.

Mikkilineni L, Whitaker-Menezes D, Domingo-Vidal M, Sprandio J, Avena P, Cotzia P, Dulau-Florea A, Gong J, Uppal G, Zhan T, Leiby B, Lin Z, Pro B, Sotgia F, Lisanti MP, Martinez-Outschoorn U.

Semin Oncol. 2017 Jun;44(3):218-225. doi: 10.1053/j.seminoncol.2017.10.003. Epub 2017 Oct 10.

3.

Cancer metabolism, stemness and tumor recurrence: MCT1 and MCT4 are functional biomarkers of metabolic symbiosis in head and neck cancer.

Curry JM, Tuluc M, Whitaker-Menezes D, Ames JA, Anantharaman A, Butera A, Leiby B, Cognetti DM, Sotgia F, Lisanti MP, Martinez-Outschoorn UE.

Cell Cycle. 2013 May 1;12(9):1371-84. doi: 10.4161/cc.24092. Epub 2013 Apr 10.

4.

Tumor-stroma metabolic relationship based on lactate shuttle can sustain prostate cancer progression.

Sanità P, Capulli M, Teti A, Galatioto GP, Vicentini C, Chiarugi P, Bologna M, Angelucci A.

BMC Cancer. 2014 Mar 5;14:154. doi: 10.1186/1471-2407-14-154.

5.

Oncogenes and inflammation rewire host energy metabolism in the tumor microenvironment: RAS and NFκB target stromal MCT4.

Martinez-Outschoorn UE, Curry JM, Ko YH, Lin Z, Tuluc M, Cognetti D, Birbe RC, Pribitkin E, Bombonati A, Pestell RG, Howell A, Sotgia F, Lisanti MP.

Cell Cycle. 2013 Aug 15;12(16):2580-97. doi: 10.4161/cc.25510. Epub 2013 Jul 8.

6.

Organized metabolic crime in prostate cancer: The coexpression of MCT1 in tumor and MCT4 in stroma is an independent prognosticator for biochemical failure.

Andersen S, Solstad Ø, Moi L, Donnem T, Eilertsen M, Nordby Y, Ness N, Richardsen E, Busund LT, Bremnes RM.

Urol Oncol. 2015 Aug;33(8):338.e9-17. doi: 10.1016/j.urolonc.2015.05.013. Epub 2015 Jun 8.

PMID:
26066969
7.

Mitochondrial metabolism in cancer metastasis: visualizing tumor cell mitochondria and the "reverse Warburg effect" in positive lymph node tissue.

Sotgia F, Whitaker-Menezes D, Martinez-Outschoorn UE, Flomenberg N, Birbe RC, Witkiewicz AK, Howell A, Philp NJ, Pestell RG, Lisanti MP.

Cell Cycle. 2012 Apr 1;11(7):1445-54. doi: 10.4161/cc.19841. Epub 2012 Apr 1.

8.

Nuclear factor E2-related factor-2 has a differential impact on MCT1 and MCT4 lactate carrier expression in colonic epithelial cells: a condition favoring metabolic symbiosis between colorectal cancer and stromal cells.

Diehl K, Dinges LA, Helm O, Ammar N, Plundrich D, Arlt A, Röcken C, Sebens S, Schäfer H.

Oncogene. 2018 Jan 4;37(1):39-51. doi: 10.1038/onc.2017.299. Epub 2017 Aug 28.

PMID:
28846107
9.

Evidence for a stromal-epithelial "lactate shuttle" in human tumors: MCT4 is a marker of oxidative stress in cancer-associated fibroblasts.

Whitaker-Menezes D, Martinez-Outschoorn UE, Lin Z, Ertel A, Flomenberg N, Witkiewicz AK, Birbe RC, Howell A, Pavlides S, Gandara R, Pestell RG, Sotgia F, Philp NJ, Lisanti MP.

Cell Cycle. 2011 Jun 1;10(11):1772-83. Epub 2011 Jun 1.

10.

CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors.

Le Floch R, Chiche J, Marchiq I, Naiken T, Ilc K, Murray CM, Critchlow SE, Roux D, Simon MP, Pouysségur J.

Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):16663-8. doi: 10.1073/pnas.1106123108. Epub 2011 Sep 19. Erratum in: Proc Natl Acad Sci U S A. 2012 Dec 4;109(49):20166. Naïken, Tanesha [corrected to Naiken, Tanesha]; Ilk, Karine [corrected to Ilc, Karine].

11.

Using the "reverse Warburg effect" to identify high-risk breast cancer patients: stromal MCT4 predicts poor clinical outcome in triple-negative breast cancers.

Witkiewicz AK, Whitaker-Menezes D, Dasgupta A, Philp NJ, Lin Z, Gandara R, Sneddon S, Martinez-Outschoorn UE, Sotgia F, Lisanti MP.

Cell Cycle. 2012 Mar 15;11(6):1108-17. doi: 10.4161/cc.11.6.19530. Epub 2012 Mar 15.

12.

Mitochondrial Metabolism as a Treatment Target in Anaplastic Thyroid Cancer.

Johnson JM, Lai SY, Cotzia P, Cognetti D, Luginbuhl A, Pribitkin EA, Zhan T, Mollaee M, Domingo-Vidal M, Chen Y, Campling B, Bar-Ad V, Birbe R, Tuluc M, Martinez Outschoorn U, Curry J.

Semin Oncol. 2015 Dec;42(6):915-22. doi: 10.1053/j.seminoncol.2015.09.025. Epub 2015 Sep 24.

13.

MCT1 Modulates Cancer Cell Pyruvate Export and Growth of Tumors that Co-express MCT1 and MCT4.

Hong CS, Graham NA, Gu W, Espindola Camacho C, Mah V, Maresh EL, Alavi M, Bagryanova L, Krotee PAL, Gardner BK, Behbahan IS, Horvath S, Chia D, Mellinghoff IK, Hurvitz SA, Dubinett SM, Critchlow SE, Kurdistani SK, Goodglick L, Braas D, Graeber TG, Christofk HR.

Cell Rep. 2016 Feb 23;14(7):1590-1601. doi: 10.1016/j.celrep.2016.01.057. Epub 2016 Feb 11.

14.

Stromal-epithelial metabolic coupling in gastric cancer: stromal MCT4 and mitochondrial TOMM20 as poor prognostic factors.

Zhao Z, Han F, He Y, Yang S, Hua L, Wu J, Zhan W.

Eur J Surg Oncol. 2014 Oct;40(10):1361-8. doi: 10.1016/j.ejso.2014.04.005. Epub 2014 Apr 28.

PMID:
24821064
15.

Metabolic coupling and the Reverse Warburg Effect in cancer: Implications for novel biomarker and anticancer agent development.

Wilde L, Roche M, Domingo-Vidal M, Tanson K, Philp N, Curry J, Martinez-Outschoorn U.

Semin Oncol. 2017 Jun;44(3):198-203. doi: 10.1053/j.seminoncol.2017.10.004. Epub 2017 Oct 10. Review.

16.

Inhibition of monocarboxyate transporter 1 by AZD3965 as a novel therapeutic approach for diffuse large B-cell lymphoma and Burkitt lymphoma.

Noble RA, Bell N, Blair H, Sikka A, Thomas H, Phillips N, Nakjang S, Miwa S, Crossland R, Rand V, Televantou D, Long A, Keun HC, Bacon CM, Bomken S, Critchlow SE, Wedge SR.

Haematologica. 2017 Jul;102(7):1247-1257. doi: 10.3324/haematol.2016.163030. Epub 2017 Apr 6.

17.

Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: visualizing the therapeutic effects of metformin in tumor tissue.

Whitaker-Menezes D, Martinez-Outschoorn UE, Flomenberg N, Birbe RC, Witkiewicz AK, Howell A, Pavlides S, Tsirigos A, Ertel A, Pestell RG, Broda P, Minetti C, Lisanti MP, Sotgia F.

Cell Cycle. 2011 Dec 1;10(23):4047-64. doi: 10.4161/cc.10.23.18151. Epub 2011 Dec 1.

18.

The metabolic microenvironment of melanomas: Prognostic value of MCT1 and MCT4.

Pinheiro C, Miranda-Gonçalves V, Longatto-Filho A, Vicente AL, Berardinelli GN, Scapulatempo-Neto C, Costa RF, Viana CR, Reis RM, Baltazar F, Vazquez VL.

Cell Cycle. 2016 Jun 2;15(11):1462-70. doi: 10.1080/15384101.2016.1175258. Epub 2016 Apr 22.

19.

Lactic acid induces lactate transport and glycolysis/OXPHOS interconversion in glioblastoma.

Duan K, Liu ZJ, Hu SQ, Huo HY, Xu ZR, Ruan JF, Sun Y, Dai LP, Yan CB, Xiong W, Cui QH, Yu HJ, Yu M, Qin Y.

Biochem Biophys Res Commun. 2018 Sep 5;503(2):888-894. doi: 10.1016/j.bbrc.2018.06.092. Epub 2018 Jun 21.

PMID:
29928884
20.

Immunohistochemical analysis of MCT1, MCT2 and MCT4 expression in rat plantaris muscle.

Hashimoto T, Masuda S, Taguchi S, Brooks GA.

J Physiol. 2005 Aug 15;567(Pt 1):121-9. Epub 2005 Jun 2.

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