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A common variant in ARHGEF10 alters delta-6 desaturase activity and influence susceptibility to hypertriglyceridemia.

de Toro-Martín J, Guénard F, Rudkowska I, Lemieux S, Couture P, Vohl MC.

J Clin Lipidol. 2018 Mar - Apr;12(2):311-320.e3. doi: 10.1016/j.jacl.2017.10.020. Epub 2017 Nov 2.


Genetic variation of the FADS1 FADS2 gene cluster and n-6 PUFA composition in erythrocyte membranes in the European Prospective Investigation into Cancer and Nutrition-Potsdam study.

Zietemann V, Kröger J, Enzenbach C, Jansen E, Fritsche A, Weikert C, Boeing H, Schulze MB.

Br J Nutr. 2010 Dec;104(12):1748-59. doi: 10.1017/S0007114510002916. Epub 2010 Aug 9.


Single nucleotide polymorphisms in the FADS gene cluster are associated with delta-5 and delta-6 desaturase activities estimated by serum fatty acid ratios.

Bokor S, Dumont J, Spinneker A, Gonzalez-Gross M, Nova E, Widhalm K, Moschonis G, Stehle P, Amouyel P, De Henauw S, Molnàr D, Moreno LA, Meirhaeghe A, Dallongeville J; HELENA Study Group.

J Lipid Res. 2010 Aug;51(8):2325-33. doi: 10.1194/jlr.M006205. Epub 2010 Apr 28.


Genetic variation at the FADS1-FADS2 gene locus influences delta-5 desaturase activity and LC-PUFA proportions after fish oil supplement.

Al-Hilal M, Alsaleh A, Maniou Z, Lewis FJ, Hall WL, Sanders TA, O'Dell SD; MARINA study team.

J Lipid Res. 2013 Feb;54(2):542-51. doi: 10.1194/jlr.P032276. Epub 2012 Nov 15.


Variation in the FADS1/2 gene cluster alters plasma n-6 PUFA and is weakly associated with hsCRP levels in healthy young adults.

Roke K, Ralston JC, Abdelmagid S, Nielsen DE, Badawi A, El-Sohemy A, Ma DW, Mutch DM.

Prostaglandins Leukot Essent Fatty Acids. 2013 Sep;89(4):257-63. doi: 10.1016/j.plefa.2013.06.003. Epub 2013 Jul 16.


Associations of estimated Δ-5-desaturase and Δ-6-desaturase activities with stroke risk factors and risk of stroke: the Kuopio Ischaemic Heart Disease Risk Factor Study.

Daneshmand R, Kurl S, Tuomainen TP, Virtanen JK.

Br J Nutr. 2017 Feb;117(4):582-590. doi: 10.1017/S000711451700054X.


Recent insights into the relation of Δ5 desaturase and Δ6 desaturase activity to the development of type 2 diabetes.

Kröger J, Schulze MB.

Curr Opin Lipidol. 2012 Feb;23(1):4-10. doi: 10.1097/MOL.0b013e32834d2dc5. Review.


The effect of FADS2 gene rs174583 polymorphism on desaturase activities, fatty acid profile, insulin resistance, biochemical indices, and incidence of type 2 diabetes.

Mazoochian L, Mohammad Sadeghi HM, Pourfarzam M.

J Res Med Sci. 2018 May 30;23:47. doi: 10.4103/jrms.JRMS_961_17. eCollection 2018.


Delta-5 and delta-6 desaturases: crucial enzymes in polyunsaturated fatty acid-related pathways with pleiotropic influences in health and disease.

Tosi F, Sartori F, Guarini P, Olivieri O, Martinelli N.

Adv Exp Med Biol. 2014;824:61-81. doi: 10.1007/978-3-319-07320-0_7. Review.


Variants in CPT1A, FADS1, and FADS2 are Associated with Higher Levels of Estimated Plasma and Erythrocyte Delta-5 Desaturases in Alaskan Eskimos.

Voruganti VS, Higgins PB, Ebbesson SO, Kennish J, Göring HH, Haack K, Laston S, Drigalenko E, Wenger CR, Harris WS, Fabsitz RR, Devereux RB, Maccluer JW, Curran JE, Carless MA, Johnson MP, Moses EK, Blangero J, Umans JG, Howard BV, Cole SA, Comuzzie AG.

Front Genet. 2012 Jun 11;3:86. doi: 10.3389/fgene.2012.00086. eCollection 2012.


Polymorphisms in FADS1 and FADS2 alter desaturase activity in young Caucasian and Asian adults.

Merino DM, Johnston H, Clarke S, Roke K, Nielsen D, Badawi A, El-Sohemy A, Ma DW, Mutch DM.

Mol Genet Metab. 2011 Jun;103(2):171-8. doi: 10.1016/j.ymgme.2011.02.012. Epub 2011 Feb 23.


The role of a FADS1 polymorphism in the association of fatty acid blood levels, BMI and blood pressure in young children-Analyses based on path models.

Wolters M, Dering C, Siani A, Russo P, Kaprio J, Risé P, Moreno LA, De Henauw S, Mehlig K, Veidebaum T, Molnár D, Tornaritis M, Iacoviello L, Pitsiladis Y, Galli C, Foraita R, Börnhorst C; IDEFICS and I. Family consortia.

PLoS One. 2017 Jul 21;12(7):e0181485. doi: 10.1371/journal.pone.0181485. eCollection 2017.


Association of changes in body fatness and fatty acid composition of plasma phospholipids during early puberty in Japanese children.

Abe Y, Okada T, Iguchi H, Saito E, Kuromori Y, Iwata F, Hara M, Mugishima H, Kitamura Y.

J Atheroscler Thromb. 2012;19(12):1102-9. Epub 2012 Aug 3.


Associations between long chain polyunsaturated fatty acids and cardiovascular lipid risk factors in youth with type 1 diabetes: SEARCH Nutrition Ancillary Study.

Couch SC, Crandell J, King I, Peairs A, Shah AS, Dolan LM, Tooze J, Crume T, Mayer-Davis E.

J Diabetes Complications. 2017 Jan;31(1):67-73. doi: 10.1016/j.jdiacomp.2016.10.002. Epub 2016 Oct 5.


FADS Gene Polymorphisms, Fatty Acid Desaturase Activities, and HDL-C in Type 2 Diabetes.

Huang MC, Chang WT, Chang HY, Chung HF, Chen FP, Huang YF, Hsu CC, Hwang SJ.

Int J Environ Res Public Health. 2017 May 28;14(6). pii: E572. doi: 10.3390/ijerph14060572.


Diet and gene expression: delta-5 and delta-6 desaturases in healthy Chinese and European subjects.

Xiang M, Rahman MA, Ai H, Li X, Harbige LS.

Ann Nutr Metab. 2006;50(6):492-8. Epub 2006 Sep 19.


Genome-Wide Association Studies of Estimated Fatty Acid Desaturase Activity in Serum and Adipose Tissue in Elderly Individuals: Associations with Insulin Sensitivity.

Marklund M, Morris AP, Mahajan A, Ingelsson E, Lindgren CM, Lind L, Risérus U.

Nutrients. 2018 Nov 17;10(11). pii: E1791. doi: 10.3390/nu10111791.


Plasma fatty acid composition, estimated desaturase activities, and their relation with the metabolic syndrome in a population at high risk of cardiovascular disease.

Mayneris-Perxachs J, Guerendiain M, Castellote AI, Estruch R, Covas MI, Fitó M, Salas-Salvadó J, Martínez-González MA, Aros F, Lamuela-Raventós RM, López-Sabater MC; for PREDIMED Study Investigators.

Clin Nutr. 2014 Feb;33(1):90-7. doi: 10.1016/j.clnu.2013.03.001. Epub 2013 Mar 28.


[Desaturases of fatty acids (FADS) and their physiological and clinical implication].

Žák A, Slabý A, Tvrzická E, Jáchymová M, Macášek J, Vecka M, Zeman M, Staňková B.

Cas Lek Cesk. 2016;155(2):15-21. Review. Czech.


The Association of Polyunsaturated Fatty Acid δ-5-Desaturase Activity with Risk Factors for Type 2 Diabetes Is Dependent on Plasma ApoB-Lipoproteins in Overweight and Obese Adults.

Lamantia V, Bissonnette S, Provost V, Devaux M, Cyr Y, Daneault C, Rosiers CD, Faraj M.

J Nutr. 2019 Jan 1;149(1):57-67. doi: 10.1093/jn/nxy238.


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