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Items: 1 to 20 of 80

1.

In-depth PtdIns(3,4,5)P3 signalosome analysis identifies DAPP1 as a negative regulator of GPVI-driven platelet function.

Durrant TN, Hutchinson JL, Heesom KJ, Anderson KE, Stephens LR, Hawkins PT, Marshall AJ, Moore SF, Hers I.

Blood Adv. 2017 Jun 13;1(14):918-932. doi: 10.1182/bloodadvances.2017005173.

2.

Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase.

Bago R, Malik N, Munson MJ, Prescott AR, Davies P, Sommer E, Shpiro N, Ward R, Cross D, Ganley IG, Alessi DR.

Biochem J. 2014 Nov 1;463(3):413-27. doi: 10.1042/BJ20140889.

3.

Non-redundant roles of phosphoinositide 3-kinase isoforms alpha and beta in glycoprotein VI-induced platelet signaling and thrombus formation.

Gilio K, Munnix IC, Mangin P, Cosemans JM, Feijge MA, van der Meijden PE, Olieslagers S, Chrzanowska-Wodnicka MB, Lillian R, Schoenwaelder S, Koyasu S, Sage SO, Jackson SP, Heemskerk JW.

J Biol Chem. 2009 Dec 4;284(49):33750-62. doi: 10.1074/jbc.M109.048439. Epub 2009 Oct 8.

4.

Ligand-Biased Regulation of PtdIns(3,4,5)P3-Dependent Signal Transduction in GPCR Control of Pituitary Hormone Release.

Pemberton JG, Chang JP.

Endocrinology. 2017 Feb 1;158(2):378-401. doi: 10.1210/en.2016-1552.

PMID:
27906555
5.

Signalling through Class I PI3Ks in mammalian cells.

Hawkins PT, Anderson KE, Davidson K, Stephens LR.

Biochem Soc Trans. 2006 Nov;34(Pt 5):647-62. Review.

PMID:
17052169
6.

Regulation of PI3K effector signalling in cancer by the phosphoinositide phosphatases.

Rodgers SJ, Ferguson DT, Mitchell CA, Ooms LM.

Biosci Rep. 2017 Feb 10;37(1). pii: BSR20160432. doi: 10.1042/BSR20160432. Print 2017 Feb 28. Review.

7.

Proteomic analysis of integrin alphaIIbbeta3 outside-in signaling reveals Src-kinase-independent phosphorylation of Dok-1 and Dok-3 leading to SHIP-1 interactions.

Senis YA, Antrobus R, Severin S, Parguiña AF, Rosa I, Zitzmann N, Watson SP, García A.

J Thromb Haemost. 2009 Oct;7(10):1718-26. doi: 10.1111/j.1538-7836.2009.03565.x. Epub 2009 Aug 11.

8.

RhoG protein regulates glycoprotein VI-Fc receptor γ-chain complex-mediated platelet activation and thrombus formation.

Kim S, Dangelmaier C, Bhavanasi D, Meng S, Wang H, Goldfinger LE, Kunapuli SP.

J Biol Chem. 2013 Nov 22;288(47):34230-8. doi: 10.1074/jbc.M113.504928. Epub 2013 Oct 8.

9.

The lipid products of phosphoinositide 3-kinase isoforms in cancer and thrombosis.

Anquetil T, Payrastre B, Gratacap MP, Viaud J.

Cancer Metastasis Rev. 2018 Sep;37(2-3):477-489. doi: 10.1007/s10555-018-9735-z. Review.

PMID:
29868934
10.

Platelet endothelial cell adhesion molecule-1 regulates collagen-stimulated platelet function by modulating the association of phosphatidylinositol 3-kinase with Grb-2-associated binding protein-1 and linker for activation of T cells.

Moraes LA, Barrett NE, Jones CI, Holbrook LM, Spyridon M, Sage T, Newman DK, Gibbins JM.

J Thromb Haemost. 2010 Nov;8(11):2530-41. doi: 10.1111/j.1538-7836.2010.04025.x.

12.

Phosphatidylinositol 3,4,5-trisphosphate triggers platelet aggregation by activating Ca2+ influx.

Lu PJ, Hsu AL, Wang DS, Chen CS.

Biochemistry. 1998 Jul 7;37(27):9776-83.

PMID:
9657691
14.

Targeted phosphotyrosine profiling of glycoprotein VI signaling implicates oligophrenin-1 in platelet filopodia formation.

Bleijerveld OB, van Holten TC, Preisinger C, van der Smagt JJ, Farndale RW, Kleefstra T, Willemsen MH, Urbanus RT, de Groot PG, Heck AJ, Roest M, Scholten A.

Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1538-43. doi: 10.1161/ATVBAHA.112.300916. Epub 2013 Apr 25.

PMID:
23619296
15.

Plant-based Food Cyanidin-3-Glucoside Modulates Human Platelet Glycoprotein VI Signaling and Inhibits Platelet Activation and Thrombus Formation.

Yao Y, Chen Y, Adili R, McKeown T, Chen P, Zhu G, Li D, Ling W, Ni H, Yang Y.

J Nutr. 2017 Oct;147(10):1917-1925. doi: 10.3945/jn.116.245944. Epub 2017 Aug 30.

PMID:
28855423
16.

Role of phosphoinositide 3-kinase beta in glycoprotein VI-mediated Akt activation in platelets.

Kim S, Mangin P, Dangelmaier C, Lillian R, Jackson SP, Daniel JL, Kunapuli SP.

J Biol Chem. 2009 Dec 4;284(49):33763-72. doi: 10.1074/jbc.M109.048553. Epub 2009 Aug 21.

17.

Phosphoinositide 3-kinases as accelerators and brakes of autophagy.

O Farrell F, Rusten TE, Stenmark H.

FEBS J. 2013 Dec;280(24):6322-37. doi: 10.1111/febs.12486. Epub 2013 Sep 5. Review.

18.

Genetic analysis of the role of protein kinase Ctheta in platelet function and thrombus formation.

Hall KJ, Harper MT, Gilio K, Cosemans JM, Heemskerk JW, Poole AW.

PLoS One. 2008 Sep 25;3(9):e3277. doi: 10.1371/journal.pone.0003277.

19.

Activation of phosphatidylinositol 3-kinase β by the platelet collagen receptors integrin α2β1 and GPVI: The role of Pyk2 and c-Cbl.

Manganaro D, Consonni A, Guidetti GF, Canobbio I, Visconte C, Kim S, Okigaki M, Falasca M, Hirsch E, Kunapuli SP, Torti M.

Biochim Biophys Acta. 2015 Aug;1853(8):1879-88. doi: 10.1016/j.bbamcr.2015.05.004. Epub 2015 May 8.

20.

ELMO1 deficiency enhances platelet function.

Patel A, Kostyak J, Dangelmaier C, Badolia R, Bhavanasi D, Aslan JE, Merali S, Kim S, Eble JA, Goldfinger L, Kunapuli S.

Blood Adv. 2019 Feb 26;3(4):575-587. doi: 10.1182/bloodadvances.2018016444.

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