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Items: 1 to 20 of 111

1.

MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma.

Huang T, Kim CK, Alvarez AA, Pangeni RP, Wan X, Song X, Shi T, Yang Y, Sastry N, Horbinski CM, Lu S, Stupp R, Kessler JA, Nishikawa R, Nakano I, Sulman EP, Lu X, James CD, Yin XM, Hu B, Cheng SY.

Cancer Cell. 2017 Dec 11;32(6):840-855.e8. doi: 10.1016/j.ccell.2017.11.005.

2.

ATG4B promotes colorectal cancer growth independent of autophagic flux.

Liu PF, Leung CM, Chang YH, Cheng JS, Chen JJ, Weng CJ, Tsai KW, Hsu CJ, Liu YC, Hsu PC, Pan HW, Shu CW.

Autophagy. 2014 Aug;10(8):1454-65. doi: 10.4161/auto.29556. Epub 2014 Jun 12.

3.

A novel ATG4B antagonist inhibits autophagy and has a negative impact on osteosarcoma tumors.

Akin D, Wang SK, Habibzadegah-Tari P, Law B, Ostrov D, Li M, Yin XM, Kim JS, Horenstein N, Dunn WA Jr.

Autophagy. 2014;10(11):2021-35. doi: 10.4161/auto.32229. Epub 2014 Oct 30.

4.

Ablation of ATG4B Suppressed Autophagy and Activated AMPK for Cell Cycle Arrest in Cancer Cells.

Liu PF, Hsu CJ, Tsai WL, Cheng JS, Chen JJ, Huang IF, Tseng HH, Chang HW, Shu CW.

Cell Physiol Biochem. 2017;44(2):728-740. doi: 10.1159/000485286. Epub 2017 Nov 23.

5.

HSF1 upregulates ATG4B expression and enhances epirubicin-induced protective autophagy in hepatocellular carcinoma cells.

Zhang N, Wu Y, Lyu X, Li B, Yan X, Xiong H, Li X, Huang G, Zeng Y, Zhang Y, Lian J, Ni Z, He F.

Cancer Lett. 2017 Nov 28;409:81-90. doi: 10.1016/j.canlet.2017.08.039. Epub 2017 Sep 6.

PMID:
28889000
6.

Autophagy impairment mediated by S-nitrosation of ATG4B leads to neurotoxicity in response to hyperglycemia.

Li Y, Zhang Y, Wang L, Wang P, Xue Y, Li X, Qiao X, Zhang X, Xu T, Liu G, Li P, Chen C.

Autophagy. 2017 Jul 3;13(7):1145-1160. doi: 10.1080/15548627.2017.1320467.

7.

ATG4B inhibitor FMK-9a induces autophagy independent on its enzyme inhibition.

Chu J, Fu Y, Xu J, Zheng X, Gu Q, Luo X, Dai Q, Zhang S, Liu P, Hong L, Li M.

Arch Biochem Biophys. 2018 Apr 15;644:29-36. doi: 10.1016/j.abb.2018.03.001. Epub 2018 Mar 3.

PMID:
29510087
8.

ATG4B inhibitors with a benzotropolone core structure block autophagy and augment efficiency of chemotherapy in mice.

Kurdi A, Cleenewerck M, Vangestel C, Lyssens S, Declercq W, Timmermans JP, Stroobants S, Augustyns K, De Meyer GRY, Van Der Veken P, Martinet W.

Biochem Pharmacol. 2017 Aug 15;138:150-162. doi: 10.1016/j.bcp.2017.06.119. Epub 2017 Jun 19.

PMID:
28642033
9.

Chalcone flavokawain B induces autophagic-cell death via reactive oxygen species-mediated signaling pathways in human gastric carcinoma and suppresses tumor growth in nude mice.

Chang CT, Hseu YC, Thiyagarajan V, Lin KY, Way TD, Korivi M, Liao JW, Yang HL.

Arch Toxicol. 2017 Oct;91(10):3341-3364. doi: 10.1007/s00204-017-1967-0. Epub 2017 Apr 3.

PMID:
28374157
10.

A reversible phospho-switch mediated by ULK1 regulates the activity of autophagy protease ATG4B.

Pengo N, Agrotis A, Prak K, Jones J, Ketteler R.

Nat Commun. 2017 Aug 18;8(1):294. doi: 10.1038/s41467-017-00303-2.

11.

SLC27A4 regulate ATG4B activity and control reactions to chemotherapeutics-induced autophagy in human lung cancer cells.

Wu S, Su J, Qian H, Guo T.

Tumour Biol. 2016 May;37(5):6943-52. doi: 10.1007/s13277-015-4587-4. Epub 2015 Dec 11.

PMID:
26662804
12.

AKT-mediated phosphorylation of ATG4B impairs mitochondrial activity and enhances the Warburg effect in hepatocellular carcinoma cells.

Ni Z, He J, Wu Y, Hu C, Dai X, Yan X, Li B, Li X, Xiong H, Li Y, Li S, Xu L, Li Y, Lian J, He F.

Autophagy. 2018;14(4):685-701. doi: 10.1080/15548627.2017.1407887. Epub 2018 Jan 29.

13.

ATG4B contains a C-terminal LIR motif important for binding and efficient cleavage of mammalian orthologs of yeast Atg8.

Skytte Rasmussen M, Mouilleron S, Kumar Shrestha B, Wirth M, Lee R, Bowitz Larsen K, Abudu Princely Y, O'Reilly N, Sjøttem E, Tooze SA, Lamark T, Johansen T.

Autophagy. 2017 May 4;13(5):834-853. doi: 10.1080/15548627.2017.1287651. Epub 2017 Feb 15.

14.

Rab7b modulates autophagic flux by interacting with Atg4B.

Kjos I, Borg Distefano M, Sætre F, Repnik U, Holland P, Jones AT, Engedal N, Simonsen A, Bakke O, Progida C.

EMBO Rep. 2017 Oct;18(10):1727-1739. doi: 10.15252/embr.201744069. Epub 2017 Aug 23.

15.

ATG4B (Autophagin-1) phosphorylation modulates autophagy.

Yang Z, Wilkie-Grantham RP, Yanagi T, Shu CW, Matsuzawa S, Reed JC.

J Biol Chem. 2015 Oct 30;290(44):26549-61. doi: 10.1074/jbc.M115.658088. Epub 2015 Sep 16.

16.

Context-dependent role of ATG4B as target for autophagy inhibition in prostate cancer therapy.

Tran E, Chow A, Goda T, Wong A, Blakely K, Rocha M, Taeb S, Hoang VC, Liu SK, Emmenegger U.

Biochem Biophys Res Commun. 2013 Nov 29;441(4):726-31. doi: 10.1016/j.bbrc.2013.10.117. Epub 2013 Oct 30.

PMID:
24184480
17.

Blockade of TGF-β signaling by the TGFβR-I kinase inhibitor LY2109761 enhances radiation response and prolongs survival in glioblastoma.

Zhang M, Kleber S, Röhrich M, Timke C, Han N, Tuettenberg J, Martin-Villalba A, Debus J, Peschke P, Wirkner U, Lahn M, Huber PE.

Cancer Res. 2011 Dec 1;71(23):7155-67. doi: 10.1158/0008-5472.CAN-11-1212. Epub 2011 Oct 17.

18.

Let-7i-Induced Atg4B Suppression Is Essential for Autophagy of Placental Trophoblast in Preeclampsia.

Xu Y, Huang X, Xie J, Chen Y, Fu J, Wang L.

J Cell Physiol. 2017 Sep;232(9):2581-2589. doi: 10.1002/jcp.25661. Epub 2017 Apr 10.

PMID:
27770612
19.

Polo‑like kinase 4 promotes tumorigenesis and induces resistance to radiotherapy in glioblastoma.

Wang J, Zuo J, Wang M, Ma X, Gao K, Bai X, Wang N, Xie W, Liu H.

Oncol Rep. 2019 Apr;41(4):2159-2167. doi: 10.3892/or.2019.7012. Epub 2019 Feb 14.

20.

Targeting the MIR34C-5p-ATG4B-autophagy axis enhances the sensitivity of cervical cancer cells to pirarubicin.

Wu Y, Ni Z, Yan X, Dai X, Hu C, Zheng Y, He F, Lian J.

Autophagy. 2016 Jul 2;12(7):1105-17. doi: 10.1080/15548627.2016.1173798. Epub 2016 Apr 20.

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