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Items: 1 to 20 of 115

1.

Activities of 11-Azaartemisinin and N-Sulfonyl Derivatives against Asexual and Transmissible Malaria Parasites.

Harmse R, Coertzen D, Wong HN, Smit FJ, van der Watt ME, Reader J, Nondaba SH, Birkholtz LM, Haynes RK, N'Da DD.

ChemMedChem. 2017 Dec 19;12(24):2086-2093. doi: 10.1002/cmdc.201700599. Epub 2017 Dec 8.

PMID:
29219249
2.

Activities of 11-Azaartemisinin and N-Sulfonyl Derivatives against Neospora caninum and Comparative Cytotoxicities.

Harmse R, Wong HN, Smit FJ, Müller J, Hemphill A, N'Da DD, Haynes RK.

ChemMedChem. 2017 Dec 19;12(24):2094-2098. doi: 10.1002/cmdc.201700600. Epub 2017 Dec 6.

PMID:
29210523
3.

Synthesis, in vitro antimalarial activities and cytotoxicities of amino-artemisinin-ferrocene derivatives.

de Lange C, Coertzen D, Smit FJ, Wentzel JF, Wong HN, Birkholtz LM, Haynes RK, N'Da DD.

Bioorg Med Chem Lett. 2018 Feb 1;28(3):289-292. doi: 10.1016/j.bmcl.2017.12.057. Epub 2017 Dec 26.

PMID:
29317166
4.

Synthesis, antimalarial activities and cytotoxicities of amino-artemisinin-1,2-disubstituted ferrocene hybrids.

de Lange C, Coertzen D, Smit FJ, Wentzel JF, Wong HN, Birkholtz LM, Haynes RK, N'Da DD.

Bioorg Med Chem Lett. 2018 Oct 15;28(19):3161-3163. doi: 10.1016/j.bmcl.2018.08.037. Epub 2018 Aug 28.

PMID:
30174153
5.

Design, economical synthesis and antiplasmodial evaluation of vanillin derived allylated chalcones and their marked synergism with artemisinin against chloroquine resistant strains of Plasmodium falciparum.

Sharma N, Mohanakrishnan D, Sharma UK, Kumar R, Richa, Sinha AK, Sahal D.

Eur J Med Chem. 2014 May 22;79:350-68. doi: 10.1016/j.ejmech.2014.03.079. Epub 2014 Apr 1.

PMID:
24747290
6.

Preparation of N-sulfonyl- and N-carbonyl-11-azaartemisinins with greatly enhanced thermal stabilities: in vitro antimalarial activities.

Haynes RK, Wong HN, Lee KW, Lung CM, Shek LY, Williams ID, Croft SL, Vivas L, Rattray L, Stewart L, Wong VK, Ko BC.

ChemMedChem. 2007 Oct;2(10):1464-79.

PMID:
17768731
7.

Synthesis and in vitro biological evaluation of dihydroartemisinyl-chalcone esters.

Smit FJ, van Biljon RA, Birkholtz LM, N'Da DD.

Eur J Med Chem. 2015 Jan 27;90:33-44. doi: 10.1016/j.ejmech.2014.11.016. Epub 2014 Nov 7.

PMID:
25461309
8.

Synthesis, antimalarial activity and cytotoxicity of 10-aminoethylether derivatives of artemisinin.

Cloete TT, Wilma Breytenbach J, Kock Cd, Smith PJ, Breytenbach JC, N'da DD.

Bioorg Med Chem. 2012 Aug 1;20(15):4701-9. doi: 10.1016/j.bmc.2012.06.014. Epub 2012 Jun 15.

PMID:
22750008
9.

Artemisone and Artemiside Are Potent Panreactive Antimalarial Agents That Also Synergize Redox Imbalance in Plasmodium falciparum Transmissible Gametocyte Stages.

Coertzen D, Reader J, van der Watt M, Nondaba SH, Gibhard L, Wiesner L, Smith P, D'Alessandro S, Taramelli D, Wong HN, du Preez JL, Wu RWK, Birkholtz LM, Haynes RK.

Antimicrob Agents Chemother. 2018 Jul 27;62(8). pii: e02214-17. doi: 10.1128/AAC.02214-17. Print 2018 Aug.

10.

Ex vivo activity of endoperoxide antimalarials, including artemisone and arterolane, against multidrug-resistant Plasmodium falciparum isolates from Cambodia.

Lanteri CA, Chaorattanakawee S, Lon C, Saunders DL, Rutvisuttinunt W, Yingyuen K, Bathurst I, Ding XC, Tyner SD.

Antimicrob Agents Chemother. 2014 Oct;58(10):5831-40. doi: 10.1128/AAC.02462-14. Epub 2014 Jul 21.

11.

In vitro inhibition of Plasmodium falciparum early and late stage gametocyte viability by extracts from eight traditionally used South African plant species.

Moyo P, Botha ME, Nondaba S, Niemand J, Maharaj VJ, Eloff JN, Louw AI, Birkholtz L.

J Ethnopharmacol. 2016 Jun 5;185:235-42. doi: 10.1016/j.jep.2016.03.036. Epub 2016 Mar 16.

PMID:
26994818
12.

Considerations on the mechanism of action of artemisinin antimalarials: part 1--the 'carbon radical' and 'heme' hypotheses.

Haynes RK, Cheu KW, N'Da D, Coghi P, Monti D.

Infect Disord Drug Targets. 2013 Aug;13(4):217-77. Review.

PMID:
24304352
13.

Synthetic chemistry fuels interdisciplinary approaches to the production of artemisinin.

Corsello MA, Garg NK.

Nat Prod Rep. 2015 Mar;32(3):359-66. doi: 10.1039/c4np00113c. Review. Erratum in: Nat Prod Rep. 2015 Mar;32(3):504.

PMID:
25342519
14.

Facile synthesis of vanillin-based novel bischalcones identifies one that induces apoptosis and displays synergy with Artemisinin in killing chloroquine resistant Plasmodium falciparum.

Sharma UK, Mohanakrishnan D, Sharma N, Equbal D, Sahal D, Sinha AK.

Eur J Med Chem. 2018 Jul 15;155:623-638. doi: 10.1016/j.ejmech.2018.06.025. Epub 2018 Jun 15.

PMID:
29929118
15.

Artemisinin-dipeptidyl vinyl sulfone hybrid molecules: design, synthesis and preliminary SAR for antiplasmodial activity and falcipain-2 inhibition.

Capela R, Oliveira R, Gonçalves LM, Domingos A, Gut J, Rosenthal PJ, Lopes F, Moreira R.

Bioorg Med Chem Lett. 2009 Jun 15;19(12):3229-32. doi: 10.1016/j.bmcl.2009.04.100. Epub 2009 May 3.

16.

Facile Preparation of N-Glycosylated 10-Piperazinyl Artemisinin Derivatives and Evaluation of Their Antimalarial and Cytotoxic Activities.

Wu Y, Parapini S, Williams ID, Misiano P, Wong HN, Taramelli D, Basilico N, Haynes RK.

Molecules. 2018 Jul 13;23(7). pii: E1713. doi: 10.3390/molecules23071713.

17.

Plasmodium falciparum K13 Mutations Differentially Impact Ozonide Susceptibility and Parasite Fitness In Vitro.

Straimer J, Gnädig NF, Stokes BH, Ehrenberger M, Crane AA, Fidock DA.

MBio. 2017 Apr 11;8(2). pii: e00172-17. doi: 10.1128/mBio.00172-17.

18.

Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy Modeling.

Le Bihan A, de Kanter R, Angulo-Barturen I, Binkert C, Boss C, Brun R, Brunner R, Buchmann S, Burrows J, Dechering KJ, Delves M, Ewerling S, Ferrer S, Fischli C, Gamo-Benito FJ, Gnädig NF, Heidmann B, Jiménez-Díaz MB, Leroy D, Martínez MS, Meyer S, Moehrle JJ, Ng CL, Noviyanti R, Ruecker A, Sanz LM, Sauerwein RW, Scheurer C, Schleiferboeck S, Sinden R, Snyder C, Straimer J, Wirjanata G, Marfurt J, Price RN, Weller T, Fischli W, Fidock DA, Clozel M, Wittlin S.

PLoS Med. 2016 Oct 4;13(10):e1002138. doi: 10.1371/journal.pmed.1002138. eCollection 2016 Oct.

19.

Preliminary Evaluation of Artemisinin-Cholesterol Conjugates as Potential Drugs for the Treatment of Intractable Forms of Malaria and Tuberculosis.

Morake M, Coertzen D, Ngwane A, Wentzel JF, Wong HN, Smit FJ, Birkholtz LM, Pietersen RD, Baker B, Wiid I, N'Da DD, Haynes RK.

ChemMedChem. 2018 Jan 8;13(1):67-77. doi: 10.1002/cmdc.201700579. Epub 2017 Dec 15.

PMID:
29193799
20.

The Spiroindolone KAE609 Does Not Induce Dormant Ring Stages in Plasmodium falciparum Parasites.

Chavchich M, Van Breda K, Rowcliffe K, Diagana TT, Edstein MD.

Antimicrob Agents Chemother. 2016 Aug 22;60(9):5167-74. doi: 10.1128/AAC.02838-15. Print 2016 Sep.

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