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Effects of hypothalamic leptin gene therapy on osteopetrosis in leptin-deficient mice.

Philbrick KA, Martin SA, Colagiovanni AR, Branscum AJ, Turner RT, Iwaniec UT.

J Endocrinol. 2018 Feb;236(2):57-68. doi: 10.1530/JOE-17-0524. Epub 2017 Nov 30.


Central leptin gene therapy corrects skeletal abnormalities in leptin-deficient ob/ob mice.

Iwaniec UT, Boghossian S, Lapke PD, Turner RT, Kalra SP.

Peptides. 2007 May;28(5):1012-9. Epub 2007 Feb 12.


Body mass influences cortical bone mass independent of leptin signaling.

Iwaniec UT, Dube MG, Boghossian S, Song H, Helferich WG, Turner RT, Kalra SP.

Bone. 2009 Mar;44(3):404-12. doi: 10.1016/j.bone.2008.10.058. Epub 2008 Nov 27.


Hypothalamic leptin gene therapy prevents weight gain without long-term detrimental effects on bone in growing and skeletally mature female rats.

Iwaniec UT, Boghossian S, Trevisiol CH, Wronski TJ, Turner RT, Kalra SP.

J Bone Miner Res. 2011 Jul;26(7):1506-16. doi: 10.1002/jbmr.365.


Peripheral leptin regulates bone formation.

Turner RT, Kalra SP, Wong CP, Philbrick KA, Lindenmaier LB, Boghossian S, Iwaniec UT.

J Bone Miner Res. 2013 Jan;28(1):22-34. doi: 10.1002/jbmr.1734.


Hypothalamic Leptin Gene Therapy Reduces Bone Marrow Adiposity in ob/ob Mice Fed Regular and High-Fat Diets.

Lindenmaier LB, Philbrick KA, Branscum AJ, Kalra SP, Turner RT, Iwaniec UT.

Front Endocrinol (Lausanne). 2016 Aug 16;7:110. doi: 10.3389/fendo.2016.00110. eCollection 2016.


Hypothalamic leptin gene therapy reduces body weight without accelerating age-related bone loss.

Turner RT, Dube M, Branscum AJ, Wong CP, Olson DA, Zhong X, Kweh MF, Larkin IV, Wronski TJ, Rosen CJ, Kalra SP, Iwaniec UT.

J Endocrinol. 2015 Dec;227(3):129-41. doi: 10.1530/JOE-15-0280. Epub 2015 Oct 20.


Morbid obesity attenuates the skeletal abnormalities associated with leptin deficiency in mice.

Turner RT, Philbrick KA, Wong CP, Olson DA, Branscum AJ, Iwaniec UT.

J Endocrinol. 2014 Oct;223(1):M1-15. doi: 10.1530/JOE-14-0224. Epub 2014 Jul 2.


Leptin increases osteoblast-specific osteocalcin release through a hypothalamic relay.

Kalra SP, Dube MG, Iwaniec UT.

Peptides. 2009 May;30(5):967-73. doi: 10.1016/j.peptides.2009.01.020. Epub 2009 Feb 7.


Increased leptin expression selectively in the hypothalamus suppresses inflammatory markers CRP and IL-6 in leptin-deficient diabetic obese mice.

Dube MG, Torto R, Kalra SP.

Peptides. 2008 Apr;29(4):593-8. doi: 10.1016/j.peptides.2008.01.001. Epub 2008 Jan 17.


Paradoxical effects of partial leptin deficiency on bone in growing female mice.

Philbrick KA, Turner RT, Branscum AJ, Wong CP, Iwaniec UT.

Anat Rec (Hoboken). 2015 Dec;298(12):2018-29. doi: 10.1002/ar.23267. Epub 2015 Oct 7.


Leptin gene transfer in the hypothalamus enhances longevity in adult monogenic mutant mice in the absence of circulating leptin.

Boghossian S, Ueno N, Dube MG, Kalra P, Kalra S.

Neurobiol Aging. 2007 Oct;28(10):1594-604. Epub 2006 Sep 29.


Diminished Chondrogenesis and Enhanced Osteoclastogenesis in Leptin-Deficient Diabetic Mice (ob/ob) Impair Pathologic, Trauma-Induced Heterotopic Ossification.

Agarwal S, Loder S, Li J, Brownley C, Peterson JR, Oluwatobi E, Drake J, Cholok D, Ranganathan K, Sung HH, Goulet J, Li S, Levi B.

Stem Cells Dev. 2015 Dec 15;24(24):2864-72. doi: 10.1089/scd.2015.0135. Epub 2015 Oct 1.


Bone abnormalities in adolescent leptin-deficient mice.

Ealey KN, Fonseca D, Archer MC, Ward WE.

Regul Pept. 2006 Sep 11;136(1-3):9-13. Epub 2006 Jun 9.


Long-term differential modulation of genes encoding orexigenic and anorexigenic peptides by leptin delivered by rAAV vector in ob/ob mice. Relationship with body weight change.

Dhillon H, Ge Y, Minter RM, Prima V, Moldawer LL, Muzyczka N, Zolotukhin S, Kalra PS, Kalra SP.

Regul Pept. 2000 Aug 25;92(1-3):97-105.


Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass.

Ducy P, Amling M, Takeda S, Priemel M, Schilling AF, Beil FT, Shen J, Vinson C, Rueger JM, Karsenty G.

Cell. 2000 Jan 21;100(2):197-207.


Effects of increased hypothalamic leptin gene expression on ovariectomy-induced bone loss in rats.

Jackson MA, Iwaniec UT, Turner RT, Wronski TJ, Kalra SP.

Peptides. 2011 Aug;32(8):1575-80. doi: 10.1016/j.peptides.2011.04.029. Epub 2011 May 27.

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