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Items: 1 to 20 of 149

1.

Induced GnasR201H expression from the endogenous Gnas locus causes fibrous dysplasia by up-regulating Wnt/β-catenin signaling.

Khan SK, Yadav PS, Elliott G, Hu DZ, Xu R, Yang Y.

Proc Natl Acad Sci U S A. 2018 Jan 16;115(3):E418-E427. doi: 10.1073/pnas.1714313114. Epub 2017 Nov 20.

2.

Expression of an active Gαs mutant in skeletal stem cells is sufficient and necessary for fibrous dysplasia initiation and maintenance.

Zhao X, Deng P, Iglesias-Bartolome R, Amornphimoltham P, Steffen DJ, Jin Y, Molinolo AA, de Castro LF, Ovejero D, Yuan Q, Chen Q, Han X, Bai D, Taylor SS, Yang Y, Collins MT, Gutkind JS.

Proc Natl Acad Sci U S A. 2018 Jan 16;115(3):E428-E437. doi: 10.1073/pnas.1713710115. Epub 2017 Dec 27.

3.

Gsα Controls Cortical Bone Quality by Regulating Osteoclast Differentiation via cAMP/PKA and β-Catenin Pathways.

Ramaswamy G, Kim H, Zhang D, Lounev V, Wu JY, Choi Y, Kaplan FS, Pignolo RJ, Shore EM.

Sci Rep. 2017 Mar 24;7:45140. doi: 10.1038/srep45140.

4.

The CREB-Smad6-Runx2 axis contributes to the impaired osteogenesis potential of bone marrow stromal cells in fibrous dysplasia of bone.

Fan QM, Yue B, Bian ZY, Xu WT, Tu B, Dai KR, Li G, Tang TT.

J Pathol. 2012 Sep;228(1):45-55. doi: 10.1002/path.4033. Epub 2012 Jun 6.

PMID:
22450860
5.

Potent constitutive cyclic AMP-generating activity of XLαs implicates this imprinted GNAS product in the pathogenesis of McCune-Albright syndrome and fibrous dysplasia of bone.

Mariot V, Wu JY, Aydin C, Mantovani G, Mahon MJ, Linglart A, Bastepe M.

Bone. 2011 Feb;48(2):312-20. doi: 10.1016/j.bone.2010.09.032. Epub 2010 Sep 29.

6.

Activation of Hedgehog signaling by loss of GNAS causes heterotopic ossification.

Regard JB, Malhotra D, Gvozdenovic-Jeremic J, Josey M, Chen M, Weinstein LS, Lu J, Shore EM, Kaplan FS, Yang Y.

Nat Med. 2013 Nov;19(11):1505-12. doi: 10.1038/nm.3314. Epub 2013 Sep 29.

7.

Osteoblast-specific expression of the fibrous dysplasia (FD)-causing mutation Gsα(R201C) produces a high bone mass phenotype but does not reproduce FD in the mouse.

Remoli C, Michienzi S, Sacchetti B, Consiglio AD, Cersosimo S, Spica E, Robey PG, Holmbeck K, Cumano A, Boyde A, Davis G, Saggio I, Riminucci M, Bianco P.

J Bone Miner Res. 2015 Jun;30(6):1030-43. doi: 10.1002/jbmr.2425.

8.

GNAS transcripts in skeletal progenitors: evidence for random asymmetric allelic expression of Gs alpha.

Michienzi S, Cherman N, Holmbeck K, Funari A, Collins MT, Bianco P, Robey PG, Riminucci M.

Hum Mol Genet. 2007 Aug 15;16(16):1921-30. Epub 2007 Jun 12.

PMID:
17566083
9.

Different roles of GNAS and cAMP signaling during early and late stages of osteogenic differentiation.

Zhang S, Kaplan FS, Shore EM.

Horm Metab Res. 2012 Sep;44(10):724-31. doi: 10.1055/s-0032-1321845. Epub 2012 Aug 17.

10.

Wnt/β-catenin signaling is differentially regulated by Gα proteins and contributes to fibrous dysplasia.

Regard JB, Cherman N, Palmer D, Kuznetsov SA, Celi FS, Guettier JM, Chen M, Bhattacharyya N, Wess J, Coughlin SR, Weinstein LS, Collins MT, Robey PG, Yang Y.

Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):20101-6. doi: 10.1073/pnas.1114656108. Epub 2011 Nov 21.

11.

Fibrous Dysplasia/McCune-Albright Syndrome: Clinical and Translational Perspectives.

Robinson C, Collins MT, Boyce AM.

Curr Osteoporos Rep. 2016 Oct;14(5):178-86. doi: 10.1007/s11914-016-0317-0. Review.

12.

GNAS mutation as an alternative mechanism of activation of the Wnt/β-catenin signaling pathway in gastric adenocarcinoma of the fundic gland type.

Nomura R, Saito T, Mitomi H, Hidaka Y, Lee SY, Watanabe S, Yao T.

Hum Pathol. 2014 Dec;45(12):2488-96. doi: 10.1016/j.humpath.2014.08.016. Epub 2014 Sep 8.

PMID:
25288233
13.

Osteosarcoma arising in fibrous dysplasia, confirmed by mutational analysis of GNAS gene.

Sugiura Y, Kanda H, Motoi N, Nomura K, Inamura K, Okada E, Matsumoto H, Shimoji T, Matsumoto S, Nakayama J, Takazawa Y, Ishikawa Y, Machinami R.

Pathol Res Pract. 2018 Feb;214(2):318-324. doi: 10.1016/j.prp.2017.10.018. Epub 2017 Nov 12.

PMID:
29268950
14.

Activating GNAS mutations in parosteal osteosarcoma.

Carter JM, Inwards CY, Jin L, Evers B, Wenger DE, Oliveira AM, Fritchie KJ.

Am J Surg Pathol. 2014 Mar;38(3):402-9. doi: 10.1097/PAS.0000000000000144.

PMID:
24525511
15.

Skeletal progenitors and the GNAS gene: fibrous dysplasia of bone read through stem cells.

Riminucci M, Robey PG, Saggio I, Bianco P.

J Mol Endocrinol. 2010 Dec;45(6):355-64. doi: 10.1677/JME-10-0097. Epub 2010 Sep 14. Review.

16.
17.

Constitutive stimulatory G protein activity in limb mesenchyme impairs bone growth.

Karaca A, Malladi VR, Zhu Y, Tafaj O, Paltrinieri E, Wu JY, He Q, Bastepe M.

Bone. 2018 May;110:230-237. doi: 10.1016/j.bone.2018.02.016. Epub 2018 Feb 20.

19.

Expression of FGF23 is correlated with serum phosphate level in isolated fibrous dysplasia.

Kobayashi K, Imanishi Y, Koshiyama H, Miyauchi A, Wakasa K, Kawata T, Goto H, Ohashi H, Koyano HM, Mochizuki R, Miki T, Inaba M, Nishizawa Y.

Life Sci. 2006 Apr 11;78(20):2295-301. Epub 2005 Dec 7.

PMID:
16337659
20.

Glucocorticoids decrease interleukin-6 levels and induce mineralization of cultured osteogenic cells from children with fibrous dysplasia.

Stanton RP, Hobson GM, Montgomery BE, Moses PA, Smith-Kirwin SM, Funanage VL.

J Bone Miner Res. 1999 Jul;14(7):1104-14.

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