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29155852,23909451,26808867,29439388,17139371,34823218,23751441,17630652,24003163,20664906,23844259,32803122,24780647,26743169,33422688,28146050,21591981,25001901,20642320,19913011,27480079,24258486,20624009,23849096,31858521,11756171,28637879,29967338,27620165,11054084,19172515,27694321,23850619,23236426,22746349,17867432,29671861,12632022,18217157,20431852,23872194,18297551,23305015,29890296,20822337,15886804,23903326,31738933,10446085,20958117,26588064,22503564,22628078,23611368,17463178,21106949,20941457,28650323,12588350,24576258,23340049,29902630,24923466,26674810,24071464,8665907,31034271,17525299,17549299,24088646,14713514,24717421,25003953,28067098,12806027,23490430,23322602,23083103,21621250,22273509,18064324,8701947,16368572,10751543,21175382,21532533,15935833,12624305,22471932,9442040,26083990,15583724,25734957,17155953,9657446,12353081,23313628,10066429,29575062,22234363,29580115,17337040,23623170,23469943,11441983,29496178,14645014,28487256,21736422,10938886,30199212,11753011,10884507,16158305,31461638,28254816,19346255,18516074,18832777,28235634,23245937,24510678,11166284,30759486,27885904,35134667,12871553,25140584,27990840,30240944,11159520,12818256,14644082,7533066,30797789,7980622,15265792,17890448,27653279,31260799,28939294,20102488,35395698,28405672,28790378,29534999,10395026,26912743,27055904,14623889,11719372,16634757,22851178,23246160,11323002,30892978,12477353,33717055,23469931,15665114,8415671,19733667,25329809,11297035,30784176,11748216,28597485,6985716,31649128,1252669,12913786,14693172,25428217,8981060,8209791,30170538,27470510,30980756,28523947,11030463,15717703,23447108,2548620,14640963,36232816,22022533,12969982,21526204,29020490,35708029,9498802,10938890,30621248,27848264,30530120,11108903,22906019,15476670,11672756,26935249,7511731,19945153,28504052,9870481,1420290,8639774,32278335,2172242,30668373,12907444,25290311,27979925,11457470,12182905,20930120,3009439,31226648,35549263,35073813,11298606,18574670,9491270,6323960,11323027,22689668,12509220,7778060,9042822,28060719,28828982,26282717,19261611,28679740,6227139,32464678,37047682,10378842,30734681,31931718,17981558,6412393,32899133,3994711,7506054,14602724,30287213,2558659,7740506,2177684,11061865,18194419,30266987,23826207,7684600,9462579,32852184,7947604,32526790,31770438,3718610,11297038,24722456,2982440,20702811,26444593,17956695,8735824,3079628,30325547,11788478,30630981,7643723,36681816,33828561,32478925,35793439,1435320,4360292,42919,21319374,9890404,23472176,10487531,33255391,29713353,26316625,31987853,32545505,215226,34207429,7350149,14633251,11672762,26683619,12871508,30926386,31162329,9743227,28629815,27867196,26489621,10638696,8610278,9408586,1737752,30810440,10209042,14644083,30355828,2826751,28682424,31200678,22073153,11350482,31831789,29443373,11706059,31240987,28452899,34209363,12423133,11457469,24820356,18664195,25247182,9054055,30630755,10973680,12521992,6221437,7865680,36252813,9801143,23740526,32296045,27815804,24888202,17454672,32672062,32418179,9485228,10871557,10827254,18039662,10037122,12951412,11505083,32717630,26184355,22588534,28319748,28727479,20087952,32704001,3402585,884907,9886314,19705256,33070381,32467473,7539769,2722718,20717958,1314605,29538230,1514698,31046542,12147294,1644174,27656709,12696575,24612435,30935283,33166431,28207883,27819526,34131167,6658713,36207457,28844963,444222,26316743,11281625,23303817,12029005,29554700,3010704,1581239,3040157,12473257,27789259,36721118,27192991,30594050,33238433,1716482,11299027,17074720,37058728,25298190,32781764,11139946,32131714,35305713,33386737,11791701,32542378,8499224,4016157,27651174,1619569,11298605,28827474,20738760,7179222,9374424,8118027,11672752,31292828,10960527,36442804,22419575,31634878,28800150,32014540,10613763,3013677,223026,6743381,9857975,3186737,8314874,30809853,28212842,25816591,28277067,33187007,1827618,12817809,29574692,34063076,15385361,10334326,175822,1519225,24324209,7330834,35378909,8873343,447655,16307036,30295273,18596227,36958516,10947913,24729754,35295075,7912680,1448798,19528814,35929193,6665772,854886,35085240,3201402,30037798,3781350,15166936,24980694,9000123,33648917,35560137,31784932,11121572,30202779,2834604,10709903,11730024,7762422,35919959,9170,34761380,24288740,21082215,7976788,29505609,7900741,9119283,28264687,847396,6262940,12871307,30346867,29078099,22916275,23830370,2379398,29111269,36477860,2714061,29532289,27751909,21937696,22442710,19429868,2792318,14629477,30481769,2848264,34410591,34269461,10827255,26559862,28001309,19817984,30010456,22995898,31440518,30531331,6991077,34684726,26519038,29723157,31969609,24376647,9662442,36142580,9213340,3008365,24792831,27487748,32544100,22204330,2489054,11460502,3035741,12367586,1204751,36230973,7262644,29456511,9671103,28300864,8863901,2833329,7668222,7470616,16079202,29526844,25585124,27177410,35742876,9079626,23256092,23307175,34749589,30561165,27460867,31610683,9717739,21530487,36694432,9751875,30066943,7334813,10527412,22366284,8402835,28639247,20086251,281504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The role of adenosine diphosphate mediated platelet responsiveness for the stability of platelet integrity in citrated whole blood under ex vivo conditions.

Koessler J, Schwarz M, Weber K, Etzel J, Koessler A, Boeck M, Kobsar A. Koessler J, et al. PLoS One. 2017 Nov 20;12(11):e0188193. doi: 10.1371/journal.pone.0188193. eCollection 2017. PLoS One. 2017. PMID: 29155852 Free PMC article.

Decreasing phosphodiesterase 5A activity contributes to platelet cGMP accumulation during storage of apheresis-derived platelet concentrates.

Kobsar A, Putz E, Yilmaz P, Weinig E, Boeck M, Koessler J. Kobsar A, et al. Transfusion. 2014 Apr;54(4):1008-14. doi: 10.1111/trf.12360. Epub 2013 Aug 2. Transfusion. 2014. PMID: 23909451

Role of Purinergic Receptor Expression and Function for Reduced Responsiveness to Adenosine Diphosphate in Washed Human Platelets.

Koessler J, Hermann S, Weber K, Koessler A, Kuhn S, Boeck M, Kobsar A. Koessler J, et al. PLoS One. 2016 Jan 25;11(1):e0147370. doi: 10.1371/journal.pone.0147370. eCollection 2016. PLoS One. 2016. PMID: 26808867 Free PMC article.

Inhibitory Effect of Flavonolignans on the P2Y12 Pathway in Blood Platelets.

Bijak M, Szelenberger R, Dziedzic A, Saluk-Bijak J. Bijak M, et al. Molecules. 2018 Feb 10;23(2):374. doi: 10.3390/molecules23020374. Molecules. 2018. PMID: 29439388 Free PMC article.

Comparison of VASP-phosphorylation assay to light-transmission aggregometry in assessing inhibition of the platelet ADP P2Y12 receptor.

Pampuch A, Cerletti C, de Gaetano G. Pampuch A, et al. Thromb Haemost. 2006 Dec;96(6):767-73. Thromb Haemost. 2006. PMID: 17139371

Curcumin by activation of adenosine A_2A receptor stimulates protein kinase a and potentiates inhibitory effect of cangrelor on platelets.

Rukoyatkina N, Shpakova V, Bogoutdinova A, Kharazova A, Mindukshev I, Gambaryan S. Rukoyatkina N, et al. Biochem Biophys Res Commun. 2022 Jan 1;586:20-26. doi: 10.1016/j.bbrc.2021.11.006. Epub 2021 Nov 4. Biochem Biophys Res Commun. 2022. PMID: 34823218

Clinical and laboratory significance of defective P2Y(12) pathway function in patients with myeloproliferative neoplasms: a pilot study.

Chang H, Shih LY, Michelson AD, Dunn P, Frelinger AL, Wang PN, Kuo MC, Lin TL, Wu JH, Tang TC. Chang H, et al. Acta Haematol. 2013;130(3):181-7. doi: 10.1159/000348413. Epub 2013 Jun 8. Acta Haematol. 2013. PMID: 23751441 Clinical Trial.

Relationships between optical aggregometry (type born) and flow cytometry in evaluating ADP-induced platelet activation.

Sbrana S, Della Pina F, Rizza A, Buffa M, De Filippis R, Gianetti J, Clerico A. Sbrana S, et al. Cytometry B Clin Cytom. 2008 Jan;74(1):30-9. doi: 10.1002/cyto.b.20360. Cytometry B Clin Cytom. 2008. PMID: 17630652 Free article.

Blockade of the purinergic P2Y12 receptor greatly increases the platelet inhibitory actions of nitric oxide.

Kirkby NS, Lundberg MH, Chan MV, Vojnovic I, Solomon AB, Emerson M, Mitchell JA, Warner TD. Kirkby NS, et al. Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):15782-7. doi: 10.1073/pnas.1218880110. Epub 2013 Sep 3. Proc Natl Acad Sci U S A. 2013. PMID: 24003163 Free PMC article.

Differential sensitivity and kinetics of response of different ex vivo tests monitoring functional variability of platelet response to clopidogrel.

Bal Dit Sollier C, Berge N, Boval B, Dubar M, Drouet L. Bal Dit Sollier C, et al. Thromb Haemost. 2010 Sep;104(3):571-81. doi: 10.1160/TH09-11-0803. Epub 2010 Jul 20. Thromb Haemost. 2010. PMID: 20664906 Clinical Trial.

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