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The structural basis of flagellin detection by NAIP5: A strategy to limit pathogen immune evasion.

Tenthorey JL, Haloupek N, López-Blanco JR, Grob P, Adamson E, Hartenian E, Lind NA, Bourgeois NM, Chacón P, Nogales E, Vance RE.

Science. 2017 Nov 17;358(6365):888-893. doi: 10.1126/science.aao1140.


Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity.

Kofoed EM, Vance RE.

Nature. 2011 Aug 28;477(7366):592-5. doi: 10.1038/nature10394.


Differential requirements for NAIP5 in activation of the NLRC4 inflammasome.

Lightfield KL, Persson J, Trinidad NJ, Brubaker SW, Kofoed EM, Sauer JD, Dunipace EA, Warren SE, Miao EA, Vance RE.

Infect Immun. 2011 Apr;79(4):1606-14. doi: 10.1128/IAI.01187-10. Epub 2011 Jan 31.


Structural basis for specific flagellin recognition by the NLR protein NAIP5.

Yang X, Yang F, Wang W, Lin G, Hu Z, Han Z, Qi Y, Zhang L, Wang J, Sui SF, Chai J.

Cell Res. 2018 Jan;28(1):35-47. doi: 10.1038/cr.2017.148. Epub 2017 Nov 28.


The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus.

Zhao Y, Yang J, Shi J, Gong YN, Lu Q, Xu H, Liu L, Shao F.

Nature. 2011 Sep 14;477(7366):596-600. doi: 10.1038/nature10510.


Formation and structure of a NAIP5-NLRC4 inflammasome induced by direct interactions with conserved N- and C-terminal regions of flagellin.

Halff EF, Diebolder CA, Versteeg M, Schouten A, Brondijk TH, Huizinga EG.

J Biol Chem. 2012 Nov 9;287(46):38460-72. doi: 10.1074/jbc.M112.393512. Epub 2012 Sep 25.


Cryoelectron Tomography of the NAIP5/NLRC4 Inflammasome: Implications for NLR Activation.

Diebolder CA, Halff EF, Koster AJ, Huizinga EG, Koning RI.

Structure. 2015 Dec 1;23(12):2349-2357. doi: 10.1016/j.str.2015.10.001. Epub 2015 Nov 12.


Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin.

Lightfield KL, Persson J, Brubaker SW, Witte CE, von Moltke J, Dunipace EA, Henry T, Sun YH, Cado D, Dietrich WF, Monack DM, Tsolis RM, Vance RE.

Nat Immunol. 2008 Oct;9(10):1171-8. doi: 10.1038/ni.1646. Epub 2008 Aug 24.


Global cellular changes induced by Legionella pneumophila infection of bone marrow-derived macrophages.

Fortier A, Faucher SP, Diallo K, Gros P.

Immunobiology. 2011 Dec;216(12):1274-85. doi: 10.1016/j.imbio.2011.06.008. Epub 2011 Jun 30.


Rapid induction of inflammatory lipid mediators by the inflammasome in vivo.

von Moltke J, Trinidad NJ, Moayeri M, Kintzer AF, Wang SB, van Rooijen N, Brown CR, Krantz BA, Leppla SH, Gronert K, Vance RE.

Nature. 2012 Oct 4;490(7418):107-11. doi: 10.1038/nature11351. Epub 2012 Aug 19.


Rosetta Stone of NLR Innate Immunity.

Lechtenberg BC, Riedl SJ.

Trends Biochem Sci. 2016 Jan;41(1):6-8. doi: 10.1016/j.tibs.2015.11.008. Epub 2015 Nov 26.


Structural and biochemical basis for induced self-propagation of NLRC4.

Hu Z, Zhou Q, Zhang C, Fan S, Cheng W, Zhao Y, Shao F, Wang HW, Sui SF, Chai J.

Science. 2015 Oct 23;350(6259):399-404. doi: 10.1126/science.aac5489. Epub 2015 Oct 8.


Flagellin-induced NLRC4 phosphorylation primes the inflammasome for activation by NAIP5.

Matusiak M, Van Opdenbosch N, Vande Walle L, Sirard JC, Kanneganti TD, Lamkanfi M.

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1541-6. doi: 10.1073/pnas.1417945112. Epub 2015 Jan 20.


A novel pathway for inducible nitric-oxide synthase activation through inflammasomes.

Buzzo CL, Campopiano JC, Massis LM, Lage SL, Cassado AA, Leme-Souza R, Cunha LD, Russo M, Zamboni DS, Amarante-Mendes GP, Bortoluci KR.

J Biol Chem. 2010 Oct 15;285(42):32087-95. doi: 10.1074/jbc.M110.124297. Epub 2010 Aug 11.


Restriction of Legionella pneumophila replication in macrophages requires concerted action of the transcriptional regulators Irf1 and Irf8 and nod-like receptors Naip5 and Nlrc4.

Fortier A, Doiron K, Saleh M, Grinstein S, Gros P.

Infect Immun. 2009 Nov;77(11):4794-805. doi: 10.1128/IAI.01546-08. Epub 2009 Aug 31.


Listeria monocytogenes engineered to activate the Nlrc4 inflammasome are severely attenuated and are poor inducers of protective immunity.

Sauer JD, Pereyre S, Archer KA, Burke TP, Hanson B, Lauer P, Portnoy DA.

Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12419-24. doi: 10.1073/pnas.1019041108. Epub 2011 Jul 11.


Inhibition of caspase-1 or gasdermin-D enable caspase-8 activation in the Naip5/NLRC4/ASC inflammasome.

Mascarenhas DPA, Cerqueira DM, Pereira MSF, Castanheira FVS, Fernandes TD, Manin GZ, Cunha LD, Zamboni DS.

PLoS Pathog. 2017 Aug 3;13(8):e1006502. doi: 10.1371/journal.ppat.1006502. eCollection 2017 Aug.


Simultaneous targeting of toll- and nod-like receptors induces effective tumor-specific immune responses.

Garaude J, Kent A, van Rooijen N, Blander JM.

Sci Transl Med. 2012 Feb 8;4(120):120ra16. doi: 10.1126/scitranslmed.3002868.


Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization.

Zhang L, Chen S, Ruan J, Wu J, Tong AB, Yin Q, Li Y, David L, Lu A, Wang WL, Marks C, Ouyang Q, Zhang X, Mao Y, Wu H.

Science. 2015 Oct 23;350(6259):404-9. doi: 10.1126/science.aac5789. Epub 2015 Oct 8.

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