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Items: 1 to 20 of 141

1.

PRN473, an inhibitor of Bruton's tyrosine kinase, inhibits neutrophil recruitment via inhibition of macrophage antigen-1 signalling.

Herter JM, Margraf A, Volmering S, Correia BE, Bradshaw JM, Bisconte A, Hill RJ, Langrish CL, Lowell CA, Zarbock A.

Br J Pharmacol. 2018 Feb;175(3):429-439. doi: 10.1111/bph.14090. Epub 2017 Dec 22.

2.

The Neutrophil Btk Signalosome Regulates Integrin Activation during Sterile Inflammation.

Volmering S, Block H, Boras M, Lowell CA, Zarbock A.

Immunity. 2016 Jan 19;44(1):73-87. doi: 10.1016/j.immuni.2015.11.011. Epub 2016 Jan 5.

3.

Selective down-regulation of neutrophil Mac-1 in endotoxemic hepatic microcirculation via IL-10.

Menezes GB, Lee WY, Zhou H, Waterhouse CC, Cara DC, Kubes P.

J Immunol. 2009 Dec 1;183(11):7557-68. doi: 10.4049/jimmunol.0901786. Epub 2009 Nov 16.

4.

Bruton Tyrosine Kinase Inhibition Attenuates Liver Damage in a Mouse Warm Ischemia and Reperfusion Model.

Palumbo T, Nakamura K, Lassman C, Kidani Y, Bensinger SJ, Busuttil R, Kupiec-Weglinski J, Zarrinpar A.

Transplantation. 2017 Feb;101(2):322-331. doi: 10.1097/TP.0000000000001552.

5.

Dual functions of Bruton's tyrosine kinase and Tec kinase during Fcgamma receptor-induced signaling and phagocytosis.

Jongstra-Bilen J, Puig Cano A, Hasija M, Xiao H, Smith CI, Cybulsky MI.

J Immunol. 2008 Jul 1;181(1):288-98.

6.

Phosphodiesterase type 4 blockade prevents platelet-mediated neutrophil recruitment at the site of vascular injury.

Totani L, Piccoli A, Dell'Elba G, Concetta A, Di Santo A, Martelli N, Federico L, Pamuklar Z, Smyth SS, Evangelista V.

Arterioscler Thromb Vasc Biol. 2014 Aug;34(8):1689-96. doi: 10.1161/ATVBAHA.114.303939. Epub 2014 Jun 12.

7.

Tyrosine kinase Btk regulates E-selectin-mediated integrin activation and neutrophil recruitment by controlling phospholipase C (PLC) gamma2 and PI3Kgamma pathways.

Mueller H, Stadtmann A, Van Aken H, Hirsch E, Wang D, Ley K, Zarbock A.

Blood. 2010 Apr 15;115(15):3118-27. doi: 10.1182/blood-2009-11-254185. Epub 2010 Feb 18.

8.

The role of the tec kinase Bruton's tyrosine kinase (Btk) in leukocyte recruitment.

Block H, Zarbock A.

Int Rev Immunol. 2012 Apr;31(2):104-18. doi: 10.3109/08830185.2012.668982. Review.

PMID:
22449072
9.

Soluble CD40 ligand stimulates CD40-dependent activation of the β2 integrin Mac-1 and protein kinase C zeda (PKCζ) in neutrophils: implications for neutrophil-platelet interactions and neutrophil oxidative burst.

Jin R, Yu S, Song Z, Zhu X, Wang C, Yan J, Wu F, Nanda A, Granger DN, Li G.

PLoS One. 2013 Jun 6;8(6):e64631. doi: 10.1371/journal.pone.0064631. Print 2013.

10.

Ability of Bruton's Tyrosine Kinase Inhibitors to Sequester Y551 and Prevent Phosphorylation Determines Potency for Inhibition of Fc Receptor but not B-Cell Receptor Signaling.

Bender AT, Gardberg A, Pereira A, Johnson T, Wu Y, Grenningloh R, Head J, Morandi F, Haselmayer P, Liu-Bujalski L.

Mol Pharmacol. 2017 Mar;91(3):208-219. doi: 10.1124/mol.116.107037. Epub 2017 Jan 6.

PMID:
28062735
11.

Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathy.

Hirahashi J, Mekala D, Van Ziffle J, Xiao L, Saffaripour S, Wagner DD, Shapiro SD, Lowell C, Mayadas TN.

Immunity. 2006 Aug;25(2):271-83. Epub 2006 Jul 27.

12.

Bruton's tyrosine kinase is required for TLR-dependent heme oxygenase-1 gene activation via Nrf2 in macrophages.

Vijayan V, Baumgart-Vogt E, Naidu S, Qian G, Immenschuh S.

J Immunol. 2011 Jul 15;187(2):817-27. doi: 10.4049/jimmunol.1003631. Epub 2011 Jun 15.

13.

Inhibition of Ras signalling reduces neutrophil infiltration and tissue damage in severe acute pancreatitis.

Yu C, Merza M, Luo L, Thorlacius H.

Eur J Pharmacol. 2015 Jan 5;746:245-51. doi: 10.1016/j.ejphar.2014.11.020. Epub 2014 Nov 25.

PMID:
25460024
14.

Rho-kinase signaling regulates pulmonary infiltration of neutrophils in abdominal sepsis via attenuation of CXC chemokine formation and Mac-1 expression on neutrophils.

Hasan Z, Palani K, Rahman M, Zhang S, Syk I, Jeppsson B, Thorlacius H.

Shock. 2012 Mar;37(3):282-8. doi: 10.1097/SHK.0b013e3182426be4.

PMID:
22266975
15.

A novel pathway of HMGB1-mediated inflammatory cell recruitment that requires Mac-1-integrin.

Orlova VV, Choi EY, Xie C, Chavakis E, Bierhaus A, Ihanus E, Ballantyne CM, Gahmberg CG, Bianchi ME, Nawroth PP, Chavakis T.

EMBO J. 2007 Feb 21;26(4):1129-39. Epub 2007 Feb 1.

16.

Inhibiting Bruton's tyrosine kinase rescues mice from lethal influenza-induced acute lung injury.

Florence JM, Krupa A, Booshehri LM, Davis SA, Matthay MA, Kurdowska AK.

Am J Physiol Lung Cell Mol Physiol. 2018 Jul 1;315(1):L52-L58. doi: 10.1152/ajplung.00047.2018. Epub 2018 Mar 8.

17.

RN486, a selective Bruton's tyrosine kinase inhibitor, abrogates immune hypersensitivity responses and arthritis in rodents.

Xu D, Kim Y, Postelnek J, Vu MD, Hu DQ, Liao C, Bradshaw M, Hsu J, Zhang J, Pashine A, Srinivasan D, Woods J, Levin A, O'Mahony A, Owens TD, Lou Y, Hill RJ, Narula S, DeMartino J, Fine JS.

J Pharmacol Exp Ther. 2012 Apr;341(1):90-103. doi: 10.1124/jpet.111.187740. Epub 2012 Jan 6.

PMID:
22228807
18.

Oral administration of Bruton's tyrosine kinase inhibitors impairs GPVI-mediated platelet function.

Rigg RA, Aslan JE, Healy LD, Wallisch M, Thierheimer ML, Loren CP, Pang J, Hinds MT, Gruber A, McCarty OJ.

Am J Physiol Cell Physiol. 2016 Mar 1;310(5):C373-80. doi: 10.1152/ajpcell.00325.2015. Epub 2015 Dec 9.

19.

The effects of Bruton tyrosine kinase inhibition on chemotaxis and superoxide generation in human neutrophils.

Broides A, Hadad N, Levy J, Levy R.

J Clin Immunol. 2014 Jul;34(5):555-60. doi: 10.1007/s10875-014-0046-z. Epub 2014 Apr 26.

PMID:
24771458
20.

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