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Active Hexose Correlated Compound (AHCC) Inhibits the Proliferation of Ovarian Cancer Cells by Suppressing Signal Transducer and Activator of Transcription 3 (STAT3) Activation.

Choi JY, Lee S, Yun SM, Suh DH, Kim K, No JH, Jeong EH, Kim YB.

Nutr Cancer. 2018 Jan;70(1):109-115. doi: 10.1080/01635581.2018.1380203. Epub 2017 Nov 7.


A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells.

Lin L, Hutzen B, Li PK, Ball S, Zuo M, DeAngelis S, Foust E, Sobo M, Friedman L, Bhasin D, Cen L, Li C, Lin J.

Neoplasia. 2010 Jan;12(1):39-50.


Capsaicin is a novel blocker of constitutive and interleukin-6-inducible STAT3 activation.

Bhutani M, Pathak AK, Nair AS, Kunnumakkara AB, Guha S, Sethi G, Aggarwal BB.

Clin Cancer Res. 2007 May 15;13(10):3024-32. Erratum in: Clin Cancer Res. 2018 Sep 1;24(17):4346.


γ-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signalling pathway in human hepatocellular carcinoma: potential role as an antiproliferative, pro-apoptotic and chemosensitizing agent.

Rajendran P, Li F, Manu KA, Shanmugam MK, Loo SY, Kumar AP, Sethi G.

Br J Pharmacol. 2011 May;163(2):283-98. doi: 10.1111/j.1476-5381.2010.01187.x.


Gambogic acid inhibits STAT3 phosphorylation through activation of protein tyrosine phosphatase SHP-1: potential role in proliferation and apoptosis.

Prasad S, Pandey MK, Yadav VR, Aggarwal BB.

Cancer Prev Res (Phila). 2011 Jul;4(7):1084-94. doi: 10.1158/1940-6207.CAPR-10-0340. Epub 2011 Apr 13. Retraction in: Cancer Prev Res (Phila). 2018 Sep;11(9):593.


Obatoclax analog SC-2001 inhibits STAT3 phosphorylation through enhancing SHP-1 expression and induces apoptosis in human breast cancer cells.

Liu CY, Su JC, Ni MH, Tseng LM, Chu PY, Wang DS, Tai WT, Kao YP, Hung MH, Shiau CW, Chen KF.

Breast Cancer Res Treat. 2014 Jul;146(1):71-84. doi: 10.1007/s10549-014-3000-0. Epub 2014 Jun 6.


Honokiol inhibits signal transducer and activator of transcription-3 signaling, proliferation, and survival of hepatocellular carcinoma cells via the protein tyrosine phosphatase SHP-1.

Rajendran P, Li F, Shanmugam MK, Vali S, Abbasi T, Kapoor S, Ahn KS, Kumar AP, Sethi G.

J Cell Physiol. 2012 May;227(5):2184-95. doi: 10.1002/jcp.22954.


Capillarisin inhibits constitutive and inducible STAT3 activation through induction of SHP-1 and SHP-2 tyrosine phosphatases.

Lee JH, Chiang SY, Nam D, Chung WS, Lee J, Na YS, Sethi G, Ahn KS.

Cancer Lett. 2014 Apr 1;345(1):140-8. doi: 10.1016/j.canlet.2013.12.008. Epub 2013 Dec 11.


Arctigenin enhances chemosensitivity of cancer cells to cisplatin through inhibition of the STAT3 signaling pathway.

Yao X, Zhu F, Zhao Z, Liu C, Luo L, Yin Z.

J Cell Biochem. 2011 Oct;112(10):2837-49. doi: 10.1002/jcb.23198.


β-Caryophyllene oxide inhibits constitutive and inducible STAT3 signaling pathway through induction of the SHP-1 protein tyrosine phosphatase.

Kim C, Cho SK, Kapoor S, Kumar A, Vali S, Abbasi T, Kim SH, Sethi G, Ahn KS.

Mol Carcinog. 2014 Oct;53(10):793-806. doi: 10.1002/mc.22035. Epub 2013 Jun 13.


Novel sorafenib analogues induce apoptosis through SHP-1 dependent STAT3 inactivation in human breast cancer cells.

Liu CY, Tseng LM, Su JC, Chang KC, Chu PY, Tai WT, Shiau CW, Chen KF.

Breast Cancer Res. 2013;15(4):R63. Erratum in: Breast Cancer Res. 2017 Jan 11;19(1):5.


Celecoxib induces apoptosis and cell-cycle arrest in nasopharyngeal carcinoma cell lines via inhibition of STAT3 phosphorylation.

Liu DB, Hu GY, Long GX, Qiu H, Mei Q, Hu GQ.

Acta Pharmacol Sin. 2012 May;33(5):682-90. doi: 10.1038/aps.2012.18. Epub 2012 Apr 16. Erratum in: Acta Pharmacol Sin. 2013 Apr;34(4):581.


Morin inhibits STAT3 tyrosine 705 phosphorylation in tumor cells through activation of protein tyrosine phosphatase SHP1.

Gupta SC, Phromnoi K, Aggarwal BB.

Biochem Pharmacol. 2013 Apr 1;85(7):898-912. doi: 10.1016/j.bcp.2012.12.018. Epub 2012 Dec 29.


Allicin Inhibits Proliferation and Invasion in Vitro and in Vivo via SHP-1-Mediated STAT3 Signaling in Cholangiocarcinoma.

Chen H, Zhu B, Zhao L, Liu Y, Zhao F, Feng J, Jin Y, Sun J, Geng R, Wei Y.

Cell Physiol Biochem. 2018;47(2):641-653. doi: 10.1159/000490019. Epub 2018 May 22.


Dihydroxypentamethoxyflavone down-regulates constitutive and inducible signal transducers and activators of transcription-3 through the induction of tyrosine phosphatase SHP-1.

Phromnoi K, Prasad S, Gupta SC, Kannappan R, Reuter S, Limtrakul P, Aggarwal BB.

Mol Pharmacol. 2011 Nov;80(5):889-99. doi: 10.1124/mol.111.073676. Epub 2011 Aug 4.


Hyperactive EGF receptor, Jaks and Stat3 signaling promote enhanced colony-forming ability, motility and migration of cisplatin-resistant ovarian cancer cells.

Yue P, Zhang X, Paladino D, Sengupta B, Ahmad S, Holloway RW, Ingersoll SB, Turkson J.

Oncogene. 2012 May 3;31(18):2309-22. doi: 10.1038/onc.2011.409. Epub 2011 Sep 12.


(-)-Oleocanthal inhibits growth and metastasis by blocking activation of STAT3 in human hepatocellular carcinoma.

Pei T, Meng Q, Han J, Sun H, Li L, Song R, Sun B, Pan S, Liang D, Liu L.

Oncotarget. 2016 Jul 12;7(28):43475-43491. doi: 10.18632/oncotarget.9782.

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