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Membrane Microdomain Disassembly Inhibits MRSA Antibiotic Resistance.

García-Fernández E, Koch G, Wagner RM, Fekete A, Stengel ST, Schneider J, Mielich-Süss B, Geibel S, Markert SM, Stigloher C, Lopez D.

Cell. 2017 Nov 30;171(6):1354-1367.e20. doi: 10.1016/j.cell.2017.10.012. Epub 2017 Nov 2.


Passive immunization against methicillin resistant Staphylococcus aureus recombinant PBP2a in sepsis model of mice: Comparable results with antibiotic therapy.

Naghshbandi RZ, Haghighat S, Mahdavi M.

Int Immunopharmacol. 2018 Mar;56:186-192. doi: 10.1016/j.intimp.2018.01.035. Epub 2018 Feb 3.


Synergistic, collaterally sensitive β-lactam combinations suppress resistance in MRSA.

Gonzales PR, Pesesky MW, Bouley R, Ballard A, Biddy BA, Suckow MA, Wolter WR, Schroeder VA, Burnham CA, Mobashery S, Chang M, Dantas G.

Nat Chem Biol. 2015 Nov;11(11):855-61. doi: 10.1038/nchembio.1911. Epub 2015 Sep 14.


In vitro Potential Effect of Morin in the Combination with β-Lactam Antibiotics Against Methicillin-Resistant Staphylococcus aureus.

Mun SH, Lee YS, Han SH, Lee SW, Cha SW, Kim SB, Seo YS, Kong R, Kang DH, Shin DW, Kang OH, Kwon DY.

Foodborne Pathog Dis. 2015 Jun;12(6):545-50. doi: 10.1089/fpd.2014.1923.


Flotillin scaffold activity contributes to type VII secretion system assembly in Staphylococcus aureus.

Mielich-Süss B, Wagner RM, Mietrach N, Hertlein T, Marincola G, Ohlsen K, Geibel S, Lopez D.

PLoS Pathog. 2017 Nov 22;13(11):e1006728. doi: 10.1371/journal.ppat.1006728. eCollection 2017 Nov.


Mechanisms of Methicillin Resistance in Staphylococcus aureus.

Peacock SJ, Paterson GK.

Annu Rev Biochem. 2015;84:577-601. doi: 10.1146/annurev-biochem-060614-034516. Review.


Molecular characterization of MRSA isolates bracketing the current EUCAST ceftaroline-susceptible breakpoint for Staphylococcus aureus: the role of PBP2a in the activity of ceftaroline.

Lahiri SD, McLaughlin RE, Whiteaker JD, Ambler JE, Alm RA.

J Antimicrob Chemother. 2015 Sep;70(9):2488-98. doi: 10.1093/jac/dkv131. Epub 2015 Jun 4.


Missense mutations in PBP2A Affecting ceftaroline susceptibility detected in epidemic hospital-acquired methicillin-resistant Staphylococcus aureus clonotypes ST228 and ST247 in Western Switzerland archived since 1998.

Kelley WL, Jousselin A, Barras C, Lelong E, Renzoni A.

Antimicrob Agents Chemother. 2015 Apr;59(4):1922-30. doi: 10.1128/AAC.04068-14. Epub 2015 Jan 12.


Staphylococcus aureus PBP4 is essential for beta-lactam resistance in community-acquired methicillin-resistant strains.

Memmi G, Filipe SR, Pinho MG, Fu Z, Cheung A.

Antimicrob Agents Chemother. 2008 Nov;52(11):3955-66. doi: 10.1128/AAC.00049-08. Epub 2008 Aug 25.


Attenuating Staphylococcus aureus Virulence by Targeting Flotillin Protein Scaffold Activity.

Koch G, Wermser C, Acosta IC, Kricks L, Stengel ST, Yepes A, Lopez D.

Cell Chem Biol. 2017 Jul 20;24(7):845-857.e6. doi: 10.1016/j.chembiol.2017.05.027. Epub 2017 Jun 29.


The mechanism of heterogeneous beta-lactam resistance in MRSA: key role of the stringent stress response.

Kim C, Mwangi M, Chung M, Milheiriço C, de Lencastre H, Tomasz A.

PLoS One. 2013 Dec 9;8(12):e82814. doi: 10.1371/journal.pone.0082814. eCollection 2013. Erratum in: PLoS One. 2014;9(1). doi:10.1371/annotation/7775dee3-7a91-4c44-9125-c7634bf909e4. Milheirço, Catarina [corrected to Milheiriço, Catarina].


Poorly Cross-Linked Peptidoglycan in MRSA Due to mecA Induction Activates the Inflammasome and Exacerbates Immunopathology.

Müller S, Wolf AJ, Iliev ID, Berg BL, Underhill DM, Liu GY.

Cell Host Microbe. 2015 Nov 11;18(5):604-12. doi: 10.1016/j.chom.2015.10.011.


Oxacillin alters the toxin expression profile of community-associated methicillin-resistant Staphylococcus aureus.

Rudkin JK, Laabei M, Edwards AM, Joo HS, Otto M, Lennon KL, O'Gara JP, Waterfield NR, Massey RC.

Antimicrob Agents Chemother. 2014;58(2):1100-7. doi: 10.1128/AAC.01618-13. Epub 2013 Dec 2.


Biofilm formation and antimicrobial resistance in methicillin-resistant Staphylococcus aureus isolated from burn patients, Iran.

Ohadian Moghadam S, Pourmand MR, Aminharati F.

J Infect Dev Ctries. 2014 Dec 15;8(12):1511-7. doi: 10.3855/jidc.5514.


Old Drugs To Treat Resistant Bugs: Methicillin-Resistant Staphylococcus aureus Isolates with mecC Are Susceptible to a Combination of Penicillin and Clavulanic Acid.

Ba X, Harrison EM, Lovering AL, Gleadall N, Zadoks R, Parkhill J, Peacock SJ, Holden MT, Paterson GK, Holmes MA.

Antimicrob Agents Chemother. 2015 Dec;59(12):7396-404. doi: 10.1128/AAC.01469-15. Epub 2015 Sep 21.


Characterization of methicillin-resistant Staphylococcus aureus displaying increased MICs of ceftaroline.

Mendes RE, Tsakris A, Sader HS, Jones RN, Biek D, McGhee P, Appelbaum PC, Kosowska-Shick K.

J Antimicrob Chemother. 2012 Jun;67(6):1321-4. doi: 10.1093/jac/dks069. Epub 2012 Mar 7.


Antimicrobial activity of ceftaroline against methicillin-resistant Staphylococcus aureus (MRSA) isolates collected in 2013-2014 at the Geneva University Hospitals.

Andrey DO, François P, Manzano C, Bonetti EJ, Harbarth S, Schrenzel J, Kelley WL, Renzoni A.

Eur J Clin Microbiol Infect Dis. 2017 Feb;36(2):343-350. doi: 10.1007/s10096-016-2807-5. Epub 2016 Oct 15.

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