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Items: 1 to 20 of 124

1.

Structural basis of human kinesin-8 function and inhibition.

Locke J, Joseph AP, Peña A, Möckel MM, Mayer TU, Topf M, Moores CA.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):E9539-E9548. doi: 10.1073/pnas.1712169114. Epub 2017 Oct 23.

2.

Kif18A uses a microtubule binding site in the tail for plus-end localization and spindle length regulation.

Weaver LN, Ems-McClung SC, Stout JR, LeBlanc C, Shaw SL, Gardner MK, Walczak CE.

Curr Biol. 2011 Sep 13;21(17):1500-6. doi: 10.1016/j.cub.2011.08.005. Epub 2011 Sep 1.

3.

A non-motor microtubule binding site is essential for the high processivity and mitotic function of kinesin-8 Kif18A.

Mayr MI, Storch M, Howard J, Mayer TU.

PLoS One. 2011;6(11):e27471. doi: 10.1371/journal.pone.0027471. Epub 2011 Nov 10.

4.

Kinesin-5: cross-bridging mechanism to targeted clinical therapy.

Wojcik EJ, Buckley RS, Richard J, Liu L, Huckaba TM, Kim S.

Gene. 2013 Dec 1;531(2):133-49. doi: 10.1016/j.gene.2013.08.004. Epub 2013 Aug 14. Review.

5.

The kinesin-8 Kif18A dampens microtubule plus-end dynamics.

Du Y, English CA, Ohi R.

Curr Biol. 2010 Feb 23;20(4):374-80. doi: 10.1016/j.cub.2009.12.049. Epub 2010 Feb 11.

6.

The human kinesin Kif18A is a motile microtubule depolymerase essential for chromosome congression.

Mayr MI, Hümmer S, Bormann J, Grüner T, Adio S, Woehlke G, Mayer TU.

Curr Biol. 2007 Mar 20;17(6):488-98. Epub 2007 Mar 8.

7.

Comprehensive structural model of the mechanochemical cycle of a mitotic motor highlights molecular adaptations in the kinesin family.

Goulet A, Major J, Jun Y, Gross SP, Rosenfeld SS, Moores CA.

Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):1837-42. doi: 10.1073/pnas.1319848111. Epub 2014 Jan 21.

8.

Biased Brownian motion as a mechanism to facilitate nanometer-scale exploration of the microtubule plus end by a kinesin-8.

Shin Y, Du Y, Collier SE, Ohi MD, Lang MJ, Ohi R.

Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):E3826-35. doi: 10.1073/pnas.1500272112. Epub 2015 Jul 6.

9.

BTB-1: a small molecule inhibitor of the mitotic motor protein Kif18A.

Catarinella M, Grüner T, Strittmatter T, Marx A, Mayer TU.

Angew Chem Int Ed Engl. 2009;48(48):9072-6. doi: 10.1002/anie.200904510. No abstract available.

PMID:
19856362
10.

The kinesin-8 motor Kif18A suppresses kinetochore movements to control mitotic chromosome alignment.

Stumpff J, von Dassow G, Wagenbach M, Asbury C, Wordeman L.

Dev Cell. 2008 Feb;14(2):252-62. doi: 10.1016/j.devcel.2007.11.014.

11.

Synthesis and biological evaluation of optimized inhibitors of the mitotic kinesin Kif18A.

Braun J, Möckel MM, Strittmatter T, Marx A, Groth U, Mayer TU.

ACS Chem Biol. 2015 Feb 20;10(2):554-60. doi: 10.1021/cb500789h. Epub 2014 Nov 26.

PMID:
25402598
12.

The mitotic kinesin-14 KlpA contains a context-dependent directionality switch.

Popchock AR, Tseng KF, Wang P, Karplus PA, Xiang X, Qiu W.

Nat Commun. 2017 Jan 4;8:13999. doi: 10.1038/ncomms13999.

13.

Kinesin-12 motors cooperate to suppress microtubule catastrophes and drive the formation of parallel microtubule bundles.

Drechsler H, McAinsh AD.

Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):E1635-44. doi: 10.1073/pnas.1516370113. Epub 2016 Mar 11.

14.

Conformation-dependent ligand regulation of ATP hydrolysis by human KSP: activation of basal hydrolysis and inhibition of microtubule-stimulated hydrolysis by a single, small molecule modulator.

Luo L, Carson JD, Molnar KS, Tuske SJ, Coales SJ, Hamuro Y, Sung CM, Sudakin V, Auger KR, Dhanak D, Jackson JR, Huang PS, Tummino PJ, Copeland RA.

J Am Chem Soc. 2008 Jun 18;130(24):7584-91. doi: 10.1021/ja710889h. Epub 2008 May 21.

PMID:
18491908
15.

A bidirectional kinesin motor in live Drosophila embryos.

Sciambi CJ, Komma DJ, Sköld HN, Hirose K, Endow SA.

Traffic. 2005 Nov;6(11):1036-46.

16.

The structural basis of force generation by the mitotic motor kinesin-5.

Goulet A, Behnke-Parks WM, Sindelar CV, Major J, Rosenfeld SS, Moores CA.

J Biol Chem. 2012 Dec 28;287(53):44654-66. doi: 10.1074/jbc.M112.404228. Epub 2012 Nov 7.

17.

A unique kinesin-8 surface loop provides specificity for chromosome alignment.

Kim H, Fonseca C, Stumpff J.

Mol Biol Cell. 2014 Nov 1;25(21):3319-29. doi: 10.1091/mbc.E14-06-1132. Epub 2014 Sep 10.

18.

A tethering mechanism controls the processivity and kinetochore-microtubule plus-end enrichment of the kinesin-8 Kif18A.

Stumpff J, Du Y, English CA, Maliga Z, Wagenbach M, Asbury CL, Wordeman L, Ohi R.

Mol Cell. 2011 Sep 2;43(5):764-75. doi: 10.1016/j.molcel.2011.07.022.

19.

Eg5 Inhibitors Have Contrasting Effects on Microtubule Stability and Metaphase Spindle Integrity.

Chen GY, Kang YJ, Gayek AS, Youyen W, Tüzel E, Ohi R, Hancock WO.

ACS Chem Biol. 2017 Apr 21;12(4):1038-1046. doi: 10.1021/acschembio.6b01040. Epub 2017 Feb 22.

20.

Minus-end-directed Kinesin-14 motors align antiparallel microtubules to control metaphase spindle length.

Hepperla AJ, Willey PT, Coombes CE, Schuster BM, Gerami-Nejad M, McClellan M, Mukherjee S, Fox J, Winey M, Odde DJ, O'Toole E, Gardner MK.

Dev Cell. 2014 Oct 13;31(1):61-72. doi: 10.1016/j.devcel.2014.07.023.

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