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Induction of Cell Cycle and NK Cell Responses by Live-Attenuated Oral Vaccines against Typhoid Fever.

Blohmke CJ, Hill J, Darton TC, Carvalho-Burger M, Eustace A, Jones C, Schreiber F, Goodier MR, Dougan G, Nakaya HI, Pollard AJ.

Front Immunol. 2017 Oct 12;8:1276. doi: 10.3389/fimmu.2017.01276. eCollection 2017.


Salmonella Typhi Bactericidal Antibodies Reduce Disease Severity but Do Not Protect against Typhoid Fever in a Controlled Human Infection Model.

Juel HB, Thomaides-Brears HB, Darton TC, Jones C, Jones E, Shrestha S, Sie R, Eustace A, Galal U, Kurupati P, Van TT, Thieu NTV, Baker S, Blohmke CJ, Pollard AJ.

Front Immunol. 2018 Jan 17;8:1916. doi: 10.3389/fimmu.2017.01916. eCollection 2017.


Oral Typhoid Vaccination With Live-Attenuated Salmonella Typhi Strain Ty21a Generates Ty21a-Responsive and Heterologous Influenza Virus-Responsive CD4+ and CD8+ T Cells at the Human Intestinal Mucosa.

Pennington SH, Thompson AL, Wright AK, Ferreira DM, Jambo KC, Wright AD, Faragher B, Gilmour JW, Gordon SB, Gordon MA.

J Infect Dis. 2016 Jun 1;213(11):1809-19. doi: 10.1093/infdis/jiw030. Epub 2016 Jan 24.


Head-to-head comparison of humoral immune responses to Vi capsular polysaccharide and Salmonella Typhi Ty21a typhoid vaccines--a randomized trial.

Kantele A, Pakkanen SH, Karttunen R, Kantele JM.

PLoS One. 2013 Apr 8;8(4):e60583. doi: 10.1371/journal.pone.0060583. Print 2013.


Salmonella enterica serovar Typhi Ty21a expressing human papillomavirus type 16 L1 as a potential live vaccine against cervical cancer and typhoid fever.

Fraillery D, Baud D, Pang SY, Schiller J, Bobst M, Zosso N, Ponci F, Nardelli-Haefliger D.

Clin Vaccine Immunol. 2007 Oct;14(10):1285-95. Epub 2007 Aug 8.


Live oral typhoid vaccine Salmonella Typhi Ty21a - a surrogate vaccine against non-typhoid salmonella?

Kantele A, Pakkanen SH, Siitonen A, Karttunen R, Kantele JM.

Vaccine. 2012 Nov 26;30(50):7238-45. doi: 10.1016/j.vaccine.2012.10.002. Epub 2012 Oct 17.


Specific and cross-reactive immune response to oral Salmonella Typhi Ty21a and parenteral Vi capsular polysaccharide typhoid vaccines administered concomitantly.

Pakkanen SH, Kantele JM, Savolainen LE, Rombo L, Kantele A.

Vaccine. 2015 Jan 9;33(3):451-8. doi: 10.1016/j.vaccine.2014.11.030. Epub 2014 Nov 26.


Cross-reactive gut-directed immune response against Salmonella enterica serovar Paratyphi A and B in typhoid fever and after oral Ty21a typhoid vaccination.

Pakkanen SH, Kantele JM, Kantele A.

Vaccine. 2012 Sep 14;30(42):6047-53. doi: 10.1016/j.vaccine.2012.07.051. Epub 2012 Aug 2.


Cross-reactive immune response elicited by parenteral Vi polysaccharide typhoid vaccine against non-typhoid Salmonellae.

Pakkanen SH, Kantele JM, Herzog C, Kantele A.

Vaccine. 2014 Jan 23;32(5):544-51. doi: 10.1016/j.vaccine.2013.12.001. Epub 2013 Dec 14.


The novel oral typhoid vaccine M01ZH09 is well tolerated and highly immunogenic in 2 vaccine presentations.

Kirkpatrick BD, Tenney KM, Larsson CJ, O'Neill JP, Ventrone C, Bentley M, Upton A, Hindle Z, Fidler C, Kutzko D, Holdridge R, Lapointe C, Hamlet S, Chatfield SN.

J Infect Dis. 2005 Aug 1;192(3):360-6. Epub 2005 Jun 30.


A review of the current status of enteric vaccines.

Levine MM, Noriega F.

P N G Med J. 1995 Dec;38(4):325-31. Review.


Age-Associated Heterogeneity of Ty21a-Induced T Cell Responses to HLA-E Restricted Salmonella Typhi Antigen Presentation.

Rudolph ME, McArthur MA, Magder LS, Barnes RS, Chen WH, Sztein MB.

Front Immunol. 2019 Mar 4;10:257. doi: 10.3389/fimmu.2019.00257. eCollection 2019.


Stable expression of Shigella sonnei form I O-polysaccharide genes recombineered into the chromosome of live Salmonella oral vaccine vector Ty21a.

Dharmasena MN, Hanisch BW, Wai TT, Kopecko DJ.

Int J Med Microbiol. 2013 Apr;303(3):105-13. doi: 10.1016/j.ijmm.2013.01.001. Epub 2013 Mar 7.


Live oral typhoid vaccine Ty21a induces cross-reactive humoral immune responses against Salmonella enterica serovar Paratyphi A and S. Paratyphi B in humans.

Wahid R, Simon R, Zafar SJ, Levine MM, Sztein MB.

Clin Vaccine Immunol. 2012 Jun;19(6):825-34. doi: 10.1128/CVI.00058-12. Epub 2012 Apr 4.


Evaluation of Salmonella enterica serovar Typhi (Ty2 aroC-ssaV-) M01ZH09, with a defined mutation in the Salmonella pathogenicity island 2, as a live, oral typhoid vaccine in human volunteers.

Kirkpatrick BD, McKenzie R, O'Neill JP, Larsson CJ, Bourgeois AL, Shimko J, Bentley M, Makin J, Chatfield S, Hindle Z, Fidler C, Robinson BE, Ventrone CH, Bansal N, Carpenter CM, Kutzko D, Hamlet S, LaPointe C, Taylor DN.

Vaccine. 2006 Jan 12;24(2):116-23. Epub 2005 Aug 18.


Progress in vaccines against typhoid fever.

Levine MM, Ferreccio C, Black RE, Tacket CO, Germanier R.

Rev Infect Dis. 1989 May-Jun;11 Suppl 3:S552-67. Review.


Impact of oral typhoid vaccination on the human gut microbiota and correlations with s. Typhi-specific immunological responses.

Eloe-Fadrosh EA, McArthur MA, Seekatz AM, Drabek EF, Rasko DA, Sztein MB, Fraser CM.

PLoS One. 2013 Apr 24;8(4):e62026. doi: 10.1371/journal.pone.0062026. Print 2013.


Experience with registered mucosal vaccines.

Dietrich G, Griot-Wenk M, Metcalfe IC, Lang AB, Viret JF.

Vaccine. 2003 Jan 30;21(7-8):678-83. Review.


Diversity of Salmonella Typhi-responsive CD4 and CD8 T cells before and after Ty21a typhoid vaccination in children and adults.

Rudolph ME, McArthur MA, Magder LS, Barnes RS, Chen WH, Sztein MB.

Int Immunol. 2019 Apr 26;31(5):315-333. doi: 10.1093/intimm/dxz011.


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