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Items: 1 to 20 of 102

1.

The driver landscape of sporadic chordoma.

Tarpey PS, Behjati S, Young MD, Martincorena I, Alexandrov LB, Farndon SJ, Guzzo C, Hardy C, Latimer C, Butler AP, Teague JW, Shlien A, Futreal PA, Shah S, Bashashati A, Jamshidi F, Nielsen TO, Huntsman D, Baumhoer D, Brandner S, Wunder J, Dickson B, Cogswell P, Sommer J, Phillips JJ, Amary MF, Tirabosco R, Pillay N, Yip S, Stratton MR, Flanagan AM, Campbell PJ.

Nat Commun. 2017 Oct 12;8(1):890. doi: 10.1038/s41467-017-01026-0.

2.

Characterization of T gene sequence variants and germline duplications in familial and sporadic chordoma.

Kelley MJ, Shi J, Ballew B, Hyland PL, Li WQ, Rotunno M, Alcorta DA, Liebsch NJ, Mitchell J, Bass S, Roberson D, Boland J, Cullen M, He J, Burdette L, Yeager M, Chanock SJ, Parry DM, Goldstein AM, Yang XR.

Hum Genet. 2014 Oct;133(10):1289-97. doi: 10.1007/s00439-014-1463-z. Epub 2014 Jul 4.

PMID:
24990759
3.

T (brachyury) gene duplication confers major susceptibility to familial chordoma.

Yang XR, Ng D, Alcorta DA, Liebsch NJ, Sheridan E, Li S, Goldstein AM, Parry DM, Kelley MJ.

Nat Genet. 2009 Nov;41(11):1176-8. doi: 10.1038/ng.454. Epub 2009 Oct 4.

4.

'The chicken or the egg?' dilemma strikes back for the controlling mechanism in chordoma(#).

Szuhai K, Hogendoorn PC.

J Pathol. 2012 Nov;228(3):261-5. doi: 10.1002/path.4102.

PMID:
22952146
5.

Novel therapeutic targets in chordoma.

Bydon M, Papadimitriou K, Witham T, Wolinsky JP, Bydon A, Sciubba D, Gokaslan Z.

Expert Opin Ther Targets. 2012 Nov;16(11):1139-43. doi: 10.1517/14728222.2012.714772. Epub 2012 Aug 4. Review.

PMID:
22860993
6.

An integrated functional genomics approach identifies the regulatory network directed by brachyury (T) in chordoma.

Nelson AC, Pillay N, Henderson S, Presneau N, Tirabosco R, Halai D, Berisha F, Flicek P, Stemple DL, Stern CD, Wardle FC, Flanagan AM.

J Pathol. 2012 Nov;228(3):274-85. doi: 10.1002/path.4082. Epub 2012 Sep 26.

7.

Notochordal Tumors: An Update on Molecular Pathology with Therapeutic Implications.

Yamaguchi T, Imada H, Iida S, Szuhai K.

Surg Pathol Clin. 2017 Sep;10(3):637-656. doi: 10.1016/j.path.2017.04.008. Epub 2017 Jun 29. Review.

PMID:
28797506
8.

Generation of chordoma cell line JHC7 and the identification of Brachyury as a novel molecular target.

Hsu W, Mohyeldin A, Shah SR, ap Rhys CM, Johnson LF, Sedora-Roman NI, Kosztowski TA, Awad OA, McCarthy EF, Loeb DM, Wolinsky JP, Gokaslan ZL, Quiñones-Hinojosa A.

J Neurosurg. 2011 Oct;115(4):760-9. doi: 10.3171/2011.5.JNS11185. Epub 2011 Jun 24.

9.

A common single-nucleotide variant in T is strongly associated with chordoma.

Pillay N, Plagnol V, Tarpey PS, Lobo SB, Presneau N, Szuhai K, Halai D, Berisha F, Cannon SR, Mead S, Kasperaviciute D, Palmen J, Talmud PJ, Kindblom LG, Amary MF, Tirabosco R, Flanagan AM.

Nat Genet. 2012 Nov;44(11):1185-7. doi: 10.1038/ng.2419. Epub 2012 Oct 14.

PMID:
23064415
10.

The brachyury Gly177Asp SNP is not associated with a risk of skull base chordoma in the Chinese population.

Wu Z, Wang K, Wang L, Feng J, Hao S, Tian K, Zhang L, Jia G, Wan H, Zhang J.

Int J Mol Sci. 2013 Oct 25;14(11):21258-65. doi: 10.3390/ijms141121258.

11.

Brachyury and chordoma: the chondroid-chordoid dilemma resolved?

Romeo S, Hogendoorn PC.

J Pathol. 2006 Jun;209(2):143-6.

PMID:
16604512
12.

From notochord formation to hereditary chordoma: the many roles of Brachyury.

Nibu Y, José-Edwards DS, Di Gregorio A.

Biomed Res Int. 2013;2013:826435. doi: 10.1155/2013/826435. Epub 2013 Mar 31. Review.

13.

Diagnosing an extra-axial chordoma of the proximal tibia with the help of brachyury, a molecule required for notochordal differentiation.

O'donnell P, Tirabosco R, Vujovic S, Bartlett W, Briggs TW, Henderson S, Boshoff C, Flanagan AM.

Skeletal Radiol. 2007 Jan;36(1):59-65. Epub 2006 Jun 30.

PMID:
16810540
14.

Molecular profiling of chordoma.

Scheil-Bertram S, Kappler R, von Baer A, Hartwig E, Sarkar M, Serra M, Brüderlein S, Westhoff B, Melzner I, Bassaly B, Herms J, Hugo HH, Schulte M, Möller P.

Int J Oncol. 2014 Apr;44(4):1041-55. doi: 10.3892/ijo.2014.2268. Epub 2014 Jan 21.

15.

Liposome-Protamine-DNA Nanoparticle-Mediated Delivery of Short Hairpin RNA Targeting Brachyury Inhibits Chordoma Cell Growth.

Hu Y, Singh R, Deng Z, Mintz A, Hsu W.

J Biomed Nanotechnol. 2016 Oct;12(10):1952-61.

PMID:
29360338
16.

Spinal column chordoma: prognostic significance of clinical variables and T (brachyury) gene SNP rs2305089 for local recurrence and overall survival.

Bettegowda C, Yip S, Lo SL, Fisher CG, Boriani S, Rhines LD, Wang JY, Lazary A, Gambarotti M, Wang WL, Luzzati A, Dekutoski MB, Bilsky MH, Chou D, Fehlings MG, McCarthy EF, Quraishi NA, Reynolds JJ, Sciubba DM, Williams RP, Wolinsky JP, Zadnik PL, Zhang M, Germscheid NM, Kalampoki V, Varga PP, Gokaslan ZL; AOSpine Knowledge Forum Tumor.

Neuro Oncol. 2017 Mar 1;19(3):405-413. doi: 10.1093/neuonc/now156.

17.

Role of the transcription factor T (brachyury) in the pathogenesis of sporadic chordoma: a genetic and functional-based study.

Presneau N, Shalaby A, Ye H, Pillay N, Halai D, Idowu B, Tirabosco R, Whitwell D, Jacques TS, Kindblom LG, Brüderlein S, Möller P, Leithner A, Liegl B, Amary FM, Athanasou NN, Hogendoorn PC, Mertens F, Szuhai K, Flanagan AM.

J Pathol. 2011 Feb;223(3):327-35. doi: 10.1002/path.2816. Epub 2010 Nov 24.

PMID:
21171078
18.

T gene isoform expression pattern is significantly different between chordomas and notochords.

Wang K, Hu Q, Wang L, Chen W, Tian K, Cao C, Wu Z, Jia G, Zhang L, Zeng C, Zhang J.

Biochem Biophys Res Commun. 2015 Nov 13;467(2):261-7. doi: 10.1016/j.bbrc.2015.09.178. Epub 2015 Oct 3.

PMID:
26435504
19.

Analysis of the fibroblastic growth factor receptor-RAS/RAF/MEK/ERK-ETS2/brachyury signalling pathway in chordomas.

Shalaby AA, Presneau N, Idowu BD, Thompson L, Briggs TR, Tirabosco R, Diss TC, Flanagan AM.

Mod Pathol. 2009 Aug;22(8):996-1005. doi: 10.1038/modpathol.2009.63. Epub 2009 May 1.

20.

[Novel molecular aspects of chordomas].

Scheil-Bertram S.

Pathologe. 2014 Nov;35 Suppl 2:237-41. doi: 10.1007/s00292-014-1986-z. German.

PMID:
25394972

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