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28971953,31707831,25626427,28302184,24627421,28772167,26683871,29653124,28486954,28191759,29706502,25528965,32693734,29019149,26171831,32112805,15878162,24141057,29993192,25523811,26439715,28089668,31695764,28123351,26313863,29168273,25304212,25836579,25520292,25898313,28167799,24778452,29879440,25385233,28165055,27133769,20506541,26335746,32827678,32120775,30355156,32169551,27790820,25792811,24200714,25867738,26239243,24370890,30071126,23395931,29967976,15023522,28125926,28110125,29298619,25618335,18625890,22843568,27616194,22191091,27084042,26511653,18021257,25609923,27179434,23995537,26359352,26061549,28063225,28011833,25529476,24357672,31518384,27132889,26991754,24446058,23027656,24112092,29337067,19103993,25043964,31087611,26191215,22693173,22083019,18757826,29086457,23265586,23732220,31406109,30169110,19633209,27500408,33440843,32212852,25967873,32863954,32183888,20659000,34120677,25392050,33983555,30063296,34499814,32694738,18682835,30959047,31615734,22912385,30620217,22898436,32243463,29626713,30744497,30129882,29335067,29987811,23197636,29930336,23573877,28224719,29107593,30224033,30215789,21737789,25286293,31206334,29700394,27631884,31402337,28912571,22896035,22843416,26892627,29258365,26021268,30684499,23707608,33830086,30946857,23193013,21460795,24141327,22890895,29044469,16176124,22645348,23963679,30449705,29111375,32182802,27023256,28165490,31573406,21364991,30098478,31080142,27324647,20163207,30112697,21852242,30145492,35112709,33145715,36544188,31087474,30038385,30292671,21822893,28279973,29579079,29662178,24527390,29637816,22862944,24444355,30400347,30358491,32594263,29021323,22750882,21203390,23918355,35041852,24647085,31564645,31031187,26952934,24526696,22821908,34728657,24192059,31722692,22020386,28266620,28843156,23526681,21423272,33048365,28916735,35536435,28777944,26323090,32151917,29866848,33645570,28131915,29865255,26052225,30290179,23904910,32314164,12242268,35813470,31617439,31685907,27539623,25077932,32053740,28573431,33910067,30503259,32157205,24936463,29382828,32763158,32725800,28883014,24693198,29917042,36583388,31778240,30508787,25937370,33743351,22165977,31825822,33951093,20109065,28484230,34959166,27768032,29987810,33615277,36263833,32514522,24505027,32758132,28288160,33774811,29957443,29768213,29720666,33712058,26103914,34519977,35524336,32450407,31792288,30727863,23086752,20091143,28819274,27492371,27934856,25865043,22848549,23778593,29125993,32271675,34845199,15005574,28829943,34855111,35093634,37059512,34759383,35082186,21149896,34051863,35806319,21513889,26788034,32272203,30679498,31419657,32446219,34321477,29363871,32453715,28165492,24312632,34297940,30321309,34209900,33712605,32700165,36583297,36055193,34828285,36035804,34158418,29920245,36608451,24978297,21617963,24519175,36173887,24483184,26515123,32556311,22100652,32276728,33454888,30686762,31545236,32106535,35099750,24311969,36791227,22412831,33949692,31690816,29435726,24675459,34638793,36361693,33009207,33724787,29145667,28696312,35516845,34309224,34485982,29020613,34460135,36681780,35063131,28176872,35073164,23342106,33757391,31502132,35061661,35587025,18552159,33178704,28777937,24069215,36208083,31136303,30013097,31710288,30317643,29896690,27358240,36836926,31940490,26324824,30314279,34339055,27805726,31207406,33160274,35304609,20724817,32490063,35583192,29021307,29217703,32853480,24146875,33928078,30656630,36335122,31051127,35395174,34831467,19816447,18713735,24012368,30348184,33941937,36225954,35507157,33149912,28497946,28727499,29554224,34722525,28819231,34088012,21603143,31249060,25170089,36039736,22248265,28540181,36999134,32619493,25007806,28462223,31448277,36795846,35382863,37096669,37028399,32952856,24840688,36589430,30018469,37080201,16719938,34772928,21949570,31143302,31697629,34644538,34993730,30023134,33371688,25074263,33207727,32117977,23277040,25328422,33150253,33280267,30800503,31887610,27308586,26553133,28414770,25071572,24618975,23740892,24618976,34708452,36950336,23493303,33321073,33294428,25696254,28676182,36715820,24693070,35174176,34841288,32529217,34910900,36518536,31249404,24693065,28081436,33013259,26692846,29192665,36565066,35141848,28447039,33868715,21331086,31620476,30504747,30586777,36658804,27777936[uid]

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Rapamycin and CHIR99021 Coordinate Robust Cardiomyocyte Differentiation From Human Pluripotent Stem Cells Via Reducing p53-Dependent Apoptosis.

Qiu XX, Liu Y, Zhang YF, Guan YN, Jia QQ, Wang C, Liang H, Li YQ, Yang HT, Qin YW, Huang S, Zhao XX, Jing Q. Qiu XX, et al. J Am Heart Assoc. 2017 Oct 2;6(10):e005295. doi: 10.1161/JAHA.116.005295. J Am Heart Assoc. 2017. PMID: 28971953 Free PMC article.

Inhibition of mTOR Signaling Enhances Maturation of Cardiomyocytes Derived From Human-Induced Pluripotent Stem Cells via p53-Induced Quiescence.

Garbern JC, Helman A, Sereda R, Sarikhani M, Ahmed A, Escalante GO, Ogurlu R, Kim SL, Zimmerman JF, Cho A, MacQueen L, Bezzerides VJ, Parker KK, Melton DA, Lee RT. Garbern JC, et al. Circulation. 2020 Jan 28;141(4):285-300. doi: 10.1161/CIRCULATIONAHA.119.044205. Epub 2019 Nov 11. Circulation. 2020. PMID: 31707831 Free PMC article.

Differentiation of Human Pluripotent Stem Cells to Cardiomyocytes Under Defined Conditions.

van den Berg CW, Elliott DA, Braam SR, Mummery CL, Davis RP. van den Berg CW, et al. Methods Mol Biol. 2016;1353:163-80. doi: 10.1007/7651_2014_178. Methods Mol Biol. 2016. PMID: 25626427

Cytokine-free directed differentiation of human pluripotent stem cells efficiently produces hemogenic endothelium with lymphoid potential.

Galat Y, Dambaeva S, Elcheva I, Khanolkar A, Beaman K, Iannaccone PM, Galat V. Galat Y, et al. Stem Cell Res Ther. 2017 Mar 17;8(1):67. doi: 10.1186/s13287-017-0519-0. Stem Cell Res Ther. 2017. PMID: 28302184 Free PMC article.

Dual modulation of the mitochondrial permeability transition pore and redox signaling synergistically promotes cardiomyocyte differentiation from pluripotent stem cells.

Cho SW, Park JS, Heo HJ, Park SW, Song S, Kim I, Han YM, Yamashita JK, Youm JB, Han J, Koh GY. Cho SW, et al. J Am Heart Assoc. 2014 Mar 13;3(2):e000693. doi: 10.1161/JAHA.113.000693. J Am Heart Assoc. 2014. PMID: 24627421 Free PMC article.

Glycogen synthase kinase-3 inhibition sensitizes human induced pluripotent stem cells to thiol-containing antioxidants induced apoptosis.

Tu C, Xu R, Koleti M, Zoldan J. Tu C, et al. Stem Cell Res. 2017 Aug;23:182-187. doi: 10.1016/j.scr.2017.07.019. Epub 2017 Jul 22. Stem Cell Res. 2017. PMID: 28772167 Free article.

Human Induced Pluripotent Stem Cell-Derived Cardiac Progenitor Cells in Phenotypic Screening: A Transforming Growth Factor-β Type 1 Receptor Kinase Inhibitor Induces Efficient Cardiac Differentiation.

Drowley L, Koonce C, Peel S, Jonebring A, Plowright AT, Kattman SJ, Andersson H, Anson B, Swanson BJ, Wang QD, Brolen G. Drowley L, et al. Stem Cells Transl Med. 2016 Feb;5(2):164-74. doi: 10.5966/sctm.2015-0114. Epub 2015 Dec 18. Stem Cells Transl Med. 2016. PMID: 26683871 Free PMC article.

Doxorubicin triggers bioenergetic failure and p53 activation in mouse stem cell-derived cardiomyocytes.

Cunha-Oliveira T, Ferreira LL, Coelho AR, Deus CM, Oliveira PJ. Cunha-Oliveira T, et al. Toxicol Appl Pharmacol. 2018 Jun 1;348:1-13. doi: 10.1016/j.taap.2018.04.009. Epub 2018 Apr 11. Toxicol Appl Pharmacol. 2018. PMID: 29653124

MiR-486 regulates cardiomyocyte apoptosis by p53-mediated BCL-2 associated mitochondrial apoptotic pathway.

Sun Y, Su Q, Li L, Wang X, Lu Y, Liang J. Sun Y, et al. BMC Cardiovasc Disord. 2017 May 10;17(1):119. doi: 10.1186/s12872-017-0549-7. BMC Cardiovasc Disord. 2017. PMID: 28486954 Free PMC article.

Heparin Promotes Cardiac Differentiation of Human Pluripotent Stem Cells in Chemically Defined Albumin-Free Medium, Enabling Consistent Manufacture of Cardiomyocytes.

Lin Y, Linask KL, Mallon B, Johnson K, Klein M, Beers J, Xie W, Du Y, Liu C, Lai Y, Zou J, Haigney M, Yang H, Rao M, Chen G. Lin Y, et al. Stem Cells Transl Med. 2017 Feb;6(2):527-538. doi: 10.5966/sctm.2015-0428. Epub 2016 Sep 2. Stem Cells Transl Med. 2017. PMID: 28191759 Free PMC article.

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