Similar articles for PMID: 28971610

Year	Number of Results
2002	1
2008	5
2009	7
2010	7
2011	11
2012	8
2013	24
2014	14
2015	14
2016	22
2017	14
2018	16
2019	16
2020	22
2021	23
2022	17
2023	14
2024	0

1

Mechanistic in vitro studies confirm that inhibition of the renal apical efflux transporter multidrug and toxin extrusion (MATE) 1, and not altered absorption, underlies the increased metformin exposure observed in clinical interactions with cimetidine, trimethoprim or pyrimethamine.

Elsby R, Chidlaw S, Outteridge S, Pickering S, Radcliffe A, Sullivan R, Jones H, Butler P. Elsby R, et al. Pharmacol Res Perspect. 2017 Oct;5(5):e00357. doi: 10.1002/prp2.357. Pharmacol Res Perspect. 2017. PMID: 28971610 Free PMC article.

2

N(1)-methylnicotinamide as an endogenous probe for drug interactions by renal cation transporters: studies on the metformin-trimethoprim interaction.

Müller F, Pontones CA, Renner B, Mieth M, Hoier E, Auge D, Maas R, Zolk O, Fromm MF. Müller F, et al. Eur J Clin Pharmacol. 2015 Jan;71(1):85-94. doi: 10.1007/s00228-014-1770-2. Epub 2014 Oct 22. Eur J Clin Pharmacol. 2015. PMID: 25552403 Clinical Trial.

3

Competitive inhibition of the luminal efflux by multidrug and toxin extrusions, but not basolateral uptake by organic cation transporter 2, is the likely mechanism underlying the pharmacokinetic drug-drug interactions caused by cimetidine in the kidney.

Ito S, Kusuhara H, Yokochi M, Toyoshima J, Inoue K, Yuasa H, Sugiyama Y. Ito S, et al. J Pharmacol Exp Ther. 2012 Feb;340(2):393-403. doi: 10.1124/jpet.111.184986. Epub 2011 Nov 9. J Pharmacol Exp Ther. 2012. PMID: 22072731

4

Role of organic cation transporter OCT2 and multidrug and toxin extrusion proteins MATE1 and MATE2-K for transport and drug interactions of the antiviral lamivudine.

Müller F, König J, Hoier E, Mandery K, Fromm MF. Müller F, et al. Biochem Pharmacol. 2013 Sep 15;86(6):808-15. doi: 10.1016/j.bcp.2013.07.008. Epub 2013 Jul 20. Biochem Pharmacol. 2013. PMID: 23876341

5

Proguanil and cycloguanil are organic cation transporter and multidrug and toxin extrusion substrates.

van der Velden M, Bilos A, van den Heuvel JJMW, Rijpma SR, Hurkmans EGE, Sauerwein RW, Russel FGM, Koenderink JB. van der Velden M, et al. Malar J. 2017 Oct 23;16(1):422. doi: 10.1186/s12936-017-2062-y. Malar J. 2017. PMID: 29061131 Free PMC article.

6

Importance of OCT2 and MATE1 for the Cimetidine-Metformin Interaction: Insights from Investigations of Polarized Transport in Single- And Double-Transfected MDCK Cells with a Focus on Perpetrator Disposition.

Müller F, Weitz D, Mertsch K, König J, Fromm MF. Müller F, et al. Mol Pharm. 2018 Aug 6;15(8):3425-3433. doi: 10.1021/acs.molpharmaceut.8b00416. Epub 2018 Jul 19. Mol Pharm. 2018. PMID: 29975542

7

Efavirenz reduces renal excretion of lamivudine in rats by inhibiting organic cation transporters (OCT, Oct) and multidrug and toxin extrusion proteins (MATE, Mate).

Ceckova M, Reznicek J, Deutsch B, Fromm MF, Staud F. Ceckova M, et al. PLoS One. 2018 Aug 16;13(8):e0202706. doi: 10.1371/journal.pone.0202706. eCollection 2018. PLoS One. 2018. PMID: 30114293 Free PMC article.

8

Renal Transporter-Mediated Drug-Biomarker Interactions of the Endogenous Substrates Creatinine and N¹ -Methylnicotinamide: A PBPK Modeling Approach.

Türk D, Müller F, Fromm MF, Selzer D, Dallmann R, Lehr T. Türk D, et al. Clin Pharmacol Ther. 2022 Sep;112(3):687-698. doi: 10.1002/cpt.2636. Epub 2022 Jun 7. Clin Pharmacol Ther. 2022. PMID: 35527512

9

Metformin and cimetidine: Physiologically based pharmacokinetic modelling to investigate transporter mediated drug-drug interactions.

Burt HJ, Neuhoff S, Almond L, Gaohua L, Harwood MD, Jamei M, Rostami-Hodjegan A, Tucker GT, Rowland-Yeo K. Burt HJ, et al. Eur J Pharm Sci. 2016 Jun 10;88:70-82. doi: 10.1016/j.ejps.2016.03.020. Epub 2016 Mar 25. Eur J Pharm Sci. 2016. PMID: 27019345 Free article.

10

Lack of Drug-Drug Interaction Between Cimetidine, a Renal Transporter Inhibitor, and Imeglimin, a Novel Oral Antidiabetic Drug, in Healthy Volunteers.

Chevalier C, Perrimond-Dauchy S, Dubourg J, Fouqueray P, Bolze S. Chevalier C, et al. Eur J Drug Metab Pharmacokinet. 2020 Dec;45(6):725-733. doi: 10.1007/s13318-020-00642-4. Eur J Drug Metab Pharmacokinet. 2020. PMID: 32860624 Clinical Trial.

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