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Skp2-Mediated Stabilization of MTH1 Promotes Survival of Melanoma Cells upon Oxidative Stress.

Wang JY, Liu GZ, Wilmott JS, La T, Feng YC, Yari H, Yan XG, Thorne RF, Scolyer RA, Zhang XD, Jin L.

Cancer Res. 2017 Nov 15;77(22):6226-6239. doi: 10.1158/0008-5472.CAN-17-1965. Epub 2017 Sep 25.


The tumor suppressor ING3 is degraded by SCF(Skp2)-mediated ubiquitin-proteasome system.

Chen G, Wang Y, Garate M, Zhou J, Li G.

Oncogene. 2010 Mar 11;29(10):1498-508. doi: 10.1038/onc.2009.424. Epub 2009 Nov 23.


MTH1 deficiency selectively increases non-cytotoxic oxidative DNA damage in lung cancer cells: more bad news than good?

Abbas HHK, Alhamoudi KMH, Evans MD, Jones GDD, Foster SS.

BMC Cancer. 2018 Apr 16;18(1):423. doi: 10.1186/s12885-018-4332-7.


Molecular dynamics simulations elucidate the mode of protein recognition by Skp1 and the F-box domain in the SCF complex.

Chandra Dantu S, Nathubhai Kachariya N, Kumar A.

Proteins. 2016 Jan;84(1):159-71. doi: 10.1002/prot.24963. Epub 2015 Dec 19.


Skp2-dependent ubiquitination and activation of LKB1 is essential for cancer cell survival under energy stress.

Lee SW, Li CF, Jin G, Cai Z, Han F, Chan CH, Yang WL, Li BK, Rezaeian AH, Li HY, Huang HY, Lin HK.

Mol Cell. 2015 Mar 19;57(6):1022-1033. doi: 10.1016/j.molcel.2015.01.015. Epub 2015 Feb 26.


The G1 phase E3 ubiquitin ligase TRUSS that gets deregulated in human cancers is a novel substrate of the S-phase E3 ubiquitin ligase Skp2.

Jamal A, Swarnalatha M, Sultana S, Joshi P, Panda SK, Kumar V.

Cell Cycle. 2015;14(16):2688-700. doi: 10.1080/15384101.2015.1056946.


Hepatitis B virus X protein enhances Myc stability by inhibiting SCF(Skp2) ubiquitin E3 ligase-mediated Myc ubiquitination and contributes to oncogenesis.

Lee S, Kim W, Ko C, Ryu WS.

Oncogene. 2016 Apr 7;35(14):1857-67. doi: 10.1038/onc.2015.251. Epub 2015 Jul 13.


Estrogen and progesterone regulate p27kip1 levels via the ubiquitin-proteasome system: pathogenic and therapeutic implications for endometrial cancer.

Huang KT, Pavlides SC, Lecanda J, Blank SV, Mittal KR, Gold LI.

PLoS One. 2012;7(9):e46072. doi: 10.1371/journal.pone.0046072. Epub 2012 Sep 27.


Regulation of neddylation and deneddylation of cullin1 in SCFSkp2 ubiquitin ligase by F-box protein and substrate.

Bornstein G, Ganoth D, Hershko A.

Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11515-20. Epub 2006 Jul 21.


Targeting the oncogenic E3 ligase Skp2 in prostate and breast cancer cells with a novel energy restriction-mimetic agent.

Wei S, Chu PC, Chuang HC, Hung WC, Kulp SK, Chen CS.

PLoS One. 2012;7(10):e47298. doi: 10.1371/journal.pone.0047298. Epub 2012 Oct 12.


SKP2 loss destabilizes EZH2 by promoting TRAF6-mediated ubiquitination to suppress prostate cancer.

Lu W, Liu S, Li B, Xie Y, Izban MG, Ballard BR, Sathyanarayana SA, Adunyah SE, Matusik RJ, Chen Z.

Oncogene. 2017 Mar;36(10):1364-1373. doi: 10.1038/onc.2016.300. Epub 2016 Nov 21.


Regulation of Skp2 expression and activity and its role in cancer progression.

Chan CH, Lee SW, Wang J, Lin HK.

ScientificWorldJournal. 2010 Jun 1;10:1001-15. doi: 10.1100/tsw.2010.89. Review.


PTEN regulates the ubiquitin-dependent degradation of the CDK inhibitor p27(KIP1) through the ubiquitin E3 ligase SCF(SKP2).

Mamillapalli R, Gavrilova N, Mihaylova VT, Tsvetkov LM, Wu H, Zhang H, Sun H.

Curr Biol. 2001 Feb 20;11(4):263-7.


Inhibitors of SCF-Skp2/Cks1 E3 ligase block estrogen-induced growth stimulation and degradation of nuclear p27kip1: therapeutic potential for endometrial cancer.

Pavlides SC, Huang KT, Reid DA, Wu L, Blank SV, Mittal K, Guo L, Rothenberg E, Rueda B, Cardozo T, Gold LI.

Endocrinology. 2013 Nov;154(11):4030-45. doi: 10.1210/en.2013-1757. Epub 2013 Sep 13.


Association of MTH1 expression with the tumor malignant potential and poor prognosis in patients with resected lung cancer.

Fujishita T, Okamoto T, Akamine T, Takamori S, Takada K, Katsura M, Toyokawa G, Shoji F, Shimokawa M, Oda Y, Nakabeppu Y, Maehara Y.

Lung Cancer. 2017 Jul;109:52-57. doi: 10.1016/j.lungcan.2017.04.012. Epub 2017 Apr 24.


Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase.

Bashir T, Dorrello NV, Amador V, Guardavaccaro D, Pagano M.

Nature. 2004 Mar 11;428(6979):190-3.


MTH1 expression is required for effective transformation by oncogenic HRAS.

Giribaldi MG, Munoz A, Halvorsen K, Patel A, Rai P.

Oncotarget. 2015 May 10;6(13):11519-29.


Skp2 regulates non-small cell lung cancer cell growth by Meg3 and miR-3163.

Su L, Han D, Wu J, Huo X.

Tumour Biol. 2016 Mar;37(3):3925-31. doi: 10.1007/s13277-015-4151-2. Epub 2015 Oct 19.


von Hippel-Lindau protein promotes Skp2 destabilization on DNA damage.

Roe JS, Kim HR, Hwang IY, Cho EJ, Youn HD.

Oncogene. 2011 Jul 14;30(28):3127-38. doi: 10.1038/onc.2011.40. Epub 2011 Feb 28.


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