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Items: 1 to 20 of 102

1.

Guide-bound structures of an RNA-targeting A-cleaving CRISPR-Cas13a enzyme.

Knott GJ, East-Seletsky A, Cofsky JC, Holton JM, Charles E, O'Connell MR, Doudna JA.

Nat Struct Mol Biol. 2017 Oct;24(10):825-833. doi: 10.1038/nsmb.3466. Epub 2017 Sep 11.

2.

The Molecular Architecture for RNA-Guided RNA Cleavage by Cas13a.

Liu L, Li X, Ma J, Li Z, You L, Wang J, Wang M, Zhang X, Wang Y.

Cell. 2017 Aug 10;170(4):714-726.e10. doi: 10.1016/j.cell.2017.06.050. Epub 2017 Jul 27.

3.

Structural Basis for the Canonical and Non-canonical PAM Recognition by CRISPR-Cpf1.

Yamano T, Zetsche B, Ishitani R, Zhang F, Nishimasu H, Nureki O.

Mol Cell. 2017 Aug 17;67(4):633-645.e3. doi: 10.1016/j.molcel.2017.06.035. Epub 2017 Aug 3.

4.

RNA Targeting by Functionally Orthogonal Type VI-A CRISPR-Cas Enzymes.

East-Seletsky A, O'Connell MR, Burstein D, Knott GJ, Doudna JA.

Mol Cell. 2017 May 4;66(3):373-383.e3. doi: 10.1016/j.molcel.2017.04.008.

5.

The CRISPR-associated DNA-cleaving enzyme Cpf1 also processes precursor CRISPR RNA.

Fonfara I, Richter H, Bratovič M, Le Rhun A, Charpentier E.

Nature. 2016 Apr 28;532(7600):517-21. doi: 10.1038/nature17945. Epub 2016 Apr 20.

PMID:
27096362
6.

Structural Variation of Type I-F CRISPR RNA Guided DNA Surveillance.

Pausch P, Müller-Esparza H, Gleditzsch D, Altegoer F, Randau L, Bange G.

Mol Cell. 2017 Aug 17;67(4):622-632.e4. doi: 10.1016/j.molcel.2017.06.036. Epub 2017 Aug 3.

7.

Structural Basis for Guide RNA Processing and Seed-Dependent DNA Targeting by CRISPR-Cas12a.

Swarts DC, van der Oost J, Jinek M.

Mol Cell. 2017 Apr 20;66(2):221-233.e4. doi: 10.1016/j.molcel.2017.03.016.

8.

Inhibition Mechanism of an Anti-CRISPR Suppressor AcrIIA4 Targeting SpyCas9.

Yang H, Patel DJ.

Mol Cell. 2017 Jul 6;67(1):117-127.e5. doi: 10.1016/j.molcel.2017.05.024. Epub 2017 Jun 9.

9.

DNA Targeting by a Minimal CRISPR RNA-Guided Cascade.

Hochstrasser ML, Taylor DW, Kornfeld JE, Nogales E, Doudna JA.

Mol Cell. 2016 Sep 1;63(5):840-51. doi: 10.1016/j.molcel.2016.07.027.

10.

Assembly of Francisella novicida Cpf1 endonuclease in complex with guide RNA and target DNA.

Alcón P, Montoya G, Stella S.

Acta Crystallogr F Struct Biol Commun. 2017 Jul 1;73(Pt 7):409-415. doi: 10.1107/S2053230X1700838X. Epub 2017 Jun 20.

11.

RNA virus interference via CRISPR/Cas13a system in plants.

Aman R, Ali Z, Butt H, Mahas A, Aljedaani F, Khan MZ, Ding S, Mahfouz M.

Genome Biol. 2018 Jan 4;19(1):1. doi: 10.1186/s13059-017-1381-1.

12.

The crystal structure of Cpf1 in complex with CRISPR RNA.

Dong D, Ren K, Qiu X, Zheng J, Guo M, Guan X, Liu H, Li N, Zhang B, Yang D, Ma C, Wang S, Wu D, Ma Y, Fan S, Wang J, Gao N, Huang Z.

Nature. 2016 Apr 28;532(7600):522-6. doi: 10.1038/nature17944. Epub 2016 Apr 20.

PMID:
27096363
13.

Substrate generation for endonucleases of CRISPR/cas systems.

Zoephel J, Dwarakanath S, Richter H, Plagens A, Randau L.

J Vis Exp. 2012 Sep 8;(67). pii: 4277. doi: 10.3791/4277.

14.

STRUCTURAL BIOLOGY. A Cas9-guide RNA complex preorganized for target DNA recognition.

Jiang F, Zhou K, Ma L, Gressel S, Doudna JA.

Science. 2015 Jun 26;348(6242):1477-81. doi: 10.1126/science.aab1452.

PMID:
26113724
15.

Probing the structural dynamics of the CRISPR-Cas9 RNA-guided DNA-cleavage system by coarse-grained modeling.

Zheng W.

Proteins. 2017 Feb;85(2):342-353. doi: 10.1002/prot.25229. Epub 2017 Jan 5.

PMID:
27936513
16.

Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection.

East-Seletsky A, O'Connell MR, Knight SC, Burstein D, Cate JH, Tjian R, Doudna JA.

Nature. 2016 Oct 13;538(7624):270-273. doi: 10.1038/nature19802. Epub 2016 Sep 26.

17.

Structural biology. Crystal structure of the CRISPR RNA-guided surveillance complex from Escherichia coli.

Jackson RN, Golden SM, van Erp PB, Carter J, Westra ER, Brouns SJ, van der Oost J, Terwilliger TC, Read RJ, Wiedenheft B.

Science. 2014 Sep 19;345(6203):1473-9. doi: 10.1126/science.1256328. Epub 2014 Aug 7.

18.

Primary processing of CRISPR RNA by the endonuclease Cas6 in Staphylococcus epidermidis.

Wakefield N, Rajan R, Sontheimer EJ.

FEBS Lett. 2015 Oct 7;589(20 Pt B):3197-204. doi: 10.1016/j.febslet.2015.09.005. Epub 2015 Sep 10.

19.

CRISPR RNA binding and DNA target recognition by purified Cascade complexes from Escherichia coli.

Beloglazova N, Kuznedelov K, Flick R, Datsenko KA, Brown G, Popovic A, Lemak S, Semenova E, Severinov K, Yakunin AF.

Nucleic Acids Res. 2015 Jan;43(1):530-43. doi: 10.1093/nar/gku1285. Epub 2014 Dec 8.

20.

Nucleic Acid-Dependent Conformational Changes in CRISPR-Cas9 Revealed by Site-Directed Spin Labeling.

Vazquez Reyes C, Tangprasertchai NS, Yogesha SD, Nguyen RH, Zhang X, Rajan R, Qin PZ.

Cell Biochem Biophys. 2017 Jun;75(2):203-210. doi: 10.1007/s12013-016-0738-5. Epub 2016 Jun 24.

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