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Items: 1 to 20 of 110

1.

Sulfonium as a Surrogate for Ammonium: A New α7 Nicotinic Acetylcholine Receptor Partial Agonist with Desensitizing Activity.

Quadri M, Stokes C, Gulsevin A, Felts ACJ, Abboud KA, Papke RL, Horenstein NA.

J Med Chem. 2017 Sep 28;60(18):7928-7934. doi: 10.1021/acs.jmedchem.7b00875. Epub 2017 Sep 14.

2.

Investigations of amide bond variation and biaryl modification in analogues of α7 nAChR agonist SEN12333.

Beinat C, Reekie T, Hibbs D, Xie T, Olson TT, Xiao Y, Harvey A, O'Connor S, Coles C, Tsanaktsidis J, Kassiou M.

Eur J Med Chem. 2014 Sep 12;84:200-5. doi: 10.1016/j.ejmech.2014.07.029. Epub 2014 Jul 9.

PMID:
25019477
3.

Identification of α7 Nicotinic Acetylcholine Receptor Silent Agonists Based on the Spirocyclic Quinuclidine-Δ2 -Isoxazoline Scaffold: Synthesis and Electrophysiological Evaluation.

Quadri M, Matera C, Silnović A, Pismataro MC, Horenstein NA, Stokes C, Papke RL, Dallanoce C.

ChemMedChem. 2017 Aug 22;12(16):1335-1348. doi: 10.1002/cmdc.201700162. Epub 2017 Jun 12.

4.

The minimal pharmacophore for silent agonism of the α7 nicotinic acetylcholine receptor.

Papke RL, Chojnacka K, Horenstein NA.

J Pharmacol Exp Ther. 2014 Sep;350(3):665-80. doi: 10.1124/jpet.114.215236. Epub 2014 Jul 2. Erratum in: J Pharmacol Exp Ther. 2015 Sep;354(3):483.

5.
6.

New quinoline derivatives as nicotinic receptor modulators.

Manetti D, Bellucci C, Dei S, Teodori E, Varani K, Spirova E, Kudryavtsev D, Shelukhina I, Tsetlin V, Romanelli MN.

Eur J Med Chem. 2016 Mar 3;110:246-58. doi: 10.1016/j.ejmech.2016.01.025. Epub 2016 Jan 19.

PMID:
26840365
7.

Selectivity optimization of substituted 1,2,3-triazoles as α7 nicotinic acetylcholine receptor agonists.

Arunrungvichian K, Fokin VV, Vajragupta O, Taylor P.

ACS Chem Neurosci. 2015 Aug 19;6(8):1317-30. doi: 10.1021/acschemneuro.5b00058. Epub 2015 May 15.

PMID:
25932897
8.

Identification and in vitro pharmacological characterization of a novel and selective α7 nicotinic acetylcholine receptor agonist, Br-IQ17B.

Tang JS, Xie BX, Bian XL, Xue Y, Wei NN, Zhou JH, Hao YC, Li G, Zhang LR, Wang KW.

Acta Pharmacol Sin. 2015 Jul;36(7):800-12. doi: 10.1038/aps.2015.9. Epub 2015 Apr 27.

9.

Electrophysiological perspectives on the therapeutic use of nicotinic acetylcholine receptor partial agonists.

Papke RL, Trocmé-Thibierge C, Guendisch D, Al Rubaiy SA, Bloom SA.

J Pharmacol Exp Ther. 2011 May;337(2):367-79. doi: 10.1124/jpet.110.177485. Epub 2011 Feb 1.

10.

Multiple pharmacophores for the selective activation of nicotinic alpha7-type acetylcholine receptors.

Horenstein NA, Leonik FM, Papke RL.

Mol Pharmacol. 2008 Dec;74(6):1496-511. doi: 10.1124/mol.108.048892. Epub 2008 Sep 2.

11.

Structurally similar allosteric modulators of α7 nicotinic acetylcholine receptors exhibit five distinct pharmacological effects.

Gill-Thind JK, Dhankher P, D'Oyley JM, Sheppard TD, Millar NS.

J Biol Chem. 2015 Feb 6;290(6):3552-62. doi: 10.1074/jbc.M114.619221. Epub 2014 Dec 16.

12.

[The structure-activity relationships of novel α7 nicotinic acetylcholine receptor agonists based on indolizine scaffold].

Li Q, Yang TY, Xue Y, Ma XZ, Tang JS, Zhang GS, Wang KW, Zhang LR.

Yao Xue Xue Bao. 2016 Oct;51(10):1584-94. Chinese.

PMID:
29932605
13.

Radiochemical synthesis and in vivo evaluation of [18F]AZ11637326: an agonist probe for the α7 nicotinic acetylcholine receptor.

Ravert HT, Dorff P, Foss CA, Mease RC, Fan H, Holmquist CR, Phillips E, McCarthy DJ, Heys JR, Holt DP, Wang Y, Endres CJ, Dannals RF, Pomper MG.

Nucl Med Biol. 2013 Aug;40(6):731-9. doi: 10.1016/j.nucmedbio.2013.04.005. Epub 2013 May 13.

PMID:
23680470
14.

Synthesis of selective agonists for the α7 nicotinic acetylcholine receptor with in situ click-chemistry on acetylcholine-binding protein templates.

Yamauchi JG, Gomez K, Grimster N, Dufouil M, Nemecz A, Fotsing JR, Ho KY, Talley TT, Sharpless KB, Fokin VV, Taylor P.

Mol Pharmacol. 2012 Oct;82(4):687-99. Epub 2012 Jul 11.

15.

Critical Molecular Determinants of α7 Nicotinic Acetylcholine Receptor Allosteric Activation: SEPARATION OF DIRECT ALLOSTERIC ACTIVATION AND POSITIVE ALLOSTERIC MODULATION.

Horenstein NA, Papke RL, Kulkarni AR, Chaturbhuj GU, Stokes C, Manther K, Thakur GA.

J Biol Chem. 2016 Mar 4;291(10):5049-67. doi: 10.1074/jbc.M115.692392. Epub 2016 Jan 7.

16.

Molecular dissection of tropisetron, an alpha7 nicotinic acetylcholine receptor-selective partial agonist.

Papke RL, Schiff HC, Jack BA, Horenstein NA.

Neurosci Lett. 2005 Apr 22;378(3):140-4. Epub 2005 Jan 5.

PMID:
15781147
17.

Discovery, cocrystallization and biological evaluation of novel piperidine derivatives as high affinity Ls-AChBP ligands possessing α7 nAChR activities.

Yang X, Shen J, Jiang L, Li W, Yu M, Pan G, Yan Y, Zhang C, Jia W, Xiao L, Yu H, Chen H, Zheng Y, Yu L, Xie Q, Zhou L, Shao L.

Eur J Med Chem. 2018 Dec 5;160:37-48. doi: 10.1016/j.ejmech.2018.09.073. Epub 2018 Oct 3.

PMID:
30317024
18.

Development of Automated Patch Clamp Assay for Evaluation of α7 Nicotinic Acetylcholine Receptor Agonists in Automated QPatch-16.

Hao Y, Tang J, Wang K.

Assay Drug Dev Technol. 2015 Apr;13(3):174-84. doi: 10.1089/adt.2014.622. Epub 2015 Apr 16.

PMID:
25880723
19.

The therapeutic potential of α7 nicotinic acetylcholine receptor (α7 nAChR) agonists for the treatment of the cognitive deficits associated with schizophrenia.

Beinat C, Banister SD, Herrera M, Law V, Kassiou M.

CNS Drugs. 2015 Jul;29(7):529-42. doi: 10.1007/s40263-015-0260-0. Review.

PMID:
26242477
20.

An unusual pattern of ligand-receptor interactions for the α7 nicotinic acetylcholine receptor, with implications for the binding of varenicline.

Van Arnam EB, Blythe EE, Lester HA, Dougherty DA.

Mol Pharmacol. 2013 Aug;84(2):201-7. doi: 10.1124/mol.113.085795. Epub 2013 May 16.

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