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Short Chain Fatty Acids Enhance Aryl Hydrocarbon (Ah) Responsiveness in Mouse Colonocytes and Caco-2 Human Colon Cancer Cells.

Jin UH, Cheng Y, Park H, Davidson LA, Callaway ES, Chapkin RS, Jayaraman A, Asante A, Allred C, Weaver EA, Safe S.

Sci Rep. 2017 Aug 31;7(1):10163. doi: 10.1038/s41598-017-10824-x.


Aryl Hydrocarbon Receptor Activity of Tryptophan Metabolites in Young Adult Mouse Colonocytes.

Cheng Y, Jin UH, Allred CD, Jayaraman A, Chapkin RS, Safe S.

Drug Metab Dispos. 2015 Oct;43(10):1536-43. doi: 10.1124/dmd.115.063677. Epub 2015 Apr 14.


Editor's Highlight: Microbial-Derived 1,4-Dihydroxy-2-naphthoic Acid and Related Compounds as Aryl Hydrocarbon Receptor Agonists/Antagonists: Structure-Activity Relationships and Receptor Modeling.

Cheng Y, Jin UH, Davidson LA, Chapkin RS, Jayaraman A, Tamamis P, Orr A, Allred C, Denison MS, Soshilov A, Weaver E, Safe S.

Toxicol Sci. 2017 Feb;155(2):458-473. doi: 10.1093/toxsci/kfw230. Epub 2016 Nov 11.


2,3,7,8-Tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase (TiPARP, ARTD14) is a mono-ADP-ribosyltransferase and repressor of aryl hydrocarbon receptor transactivation.

MacPherson L, Tamblyn L, Rajendra S, Bralha F, McPherson JP, Matthews J.

Nucleic Acids Res. 2013 Feb 1;41(3):1604-21. doi: 10.1093/nar/gks1337. Epub 2012 Dec 28.


Aryl hydrocarbon receptor repressor and TiPARP (ARTD14) use similar, but also distinct mechanisms to repress aryl hydrocarbon receptor signaling.

MacPherson L, Ahmed S, Tamblyn L, Krutmann J, Förster I, Weighardt H, Matthews J.

Int J Mol Sci. 2014 May 6;15(5):7939-57. doi: 10.3390/ijms15057939.


Microbiome-derived tryptophan metabolites and their aryl hydrocarbon receptor-dependent agonist and antagonist activities.

Jin UH, Lee SO, Sridharan G, Lee K, Davidson LA, Jayaraman A, Chapkin RS, Alaniz R, Safe S.

Mol Pharmacol. 2014 May;85(5):777-88. doi: 10.1124/mol.113.091165. Epub 2014 Feb 21.


Knockout of the aryl hydrocarbon receptor results in distinct hepatic and renal phenotypes in rats and mice.

Harrill JA, Hukkanen RR, Lawson M, Martin G, Gilger B, Soldatow V, Lecluyse EL, Budinsky RA, Rowlands JC, Thomas RS.

Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13.


Analysis of the transcriptional regulation and molecular function of the aryl hydrocarbon receptor repressor in human cell lines.

Haarmann-Stemmann T, Bothe H, Kohli A, Sydlik U, Abel J, Fritsche E.

Drug Metab Dispos. 2007 Dec;35(12):2262-9. Epub 2007 Sep 21.


The effects of short-chain fatty acids on human colon cancer cell phenotype are associated with histone hyperacetylation.

Hinnebusch BF, Meng S, Wu JT, Archer SY, Hodin RA.

J Nutr. 2002 May;132(5):1012-7.


Identification of the aryl hydrocarbon receptor target gene TiPARP as a mediator of suppression of hepatic gluconeogenesis by 2,3,7,8-tetrachlorodibenzo-p-dioxin and of nicotinamide as a corrective agent for this effect.

Diani-Moore S, Ram P, Li X, Mondal P, Youn DY, Sauve AA, Rifkind AB.

J Biol Chem. 2010 Dec 10;285(50):38801-10. doi: 10.1074/jbc.M110.131573. Epub 2010 Sep 28.


HDAC6 modulates Hsp90 chaperone activity and regulates activation of aryl hydrocarbon receptor signaling.

Kekatpure VD, Dannenberg AJ, Subbaramaiah K.

J Biol Chem. 2009 Mar 20;284(12):7436-45. doi: 10.1074/jbc.M808999200. Epub 2009 Jan 21.


Estrogen regulates Ah responsiveness in MCF-7 breast cancer cells.

Spink DC, Katz BH, Hussain MM, Pentecost BT, Cao Z, Spink BC.

Carcinogenesis. 2003 Dec;24(12):1941-50. Epub 2003 Sep 11.


3-Methylcholanthrene Induces Chylous Ascites in TCDD-Inducible Poly-ADP-Ribose Polymerase (Tiparp) Knockout Mice.

Cho TE, Bott D, Ahmed S, Hutin D, Gomez A, Tamblyn L, Zhou AC, Watts TH, Grant DM, Matthews J.

Int J Mol Sci. 2019 May 10;20(9). pii: E2312. doi: 10.3390/ijms20092312.


Metabolism-based polycyclic aromatic acetylene inhibition of CYP1B1 in 10T1/2 cells potentiates aryl hydrocarbon receptor activity.

Alexander DL, Zhang L, Foroozesh M, Alworth WL, Jefcoate CR.

Toxicol Appl Pharmacol. 1999 Dec 1;161(2):123-39.


Transgenic Overexpression of Aryl Hydrocarbon Receptor Repressor (AhRR) and AhR-Mediated Induction of CYP1A1, Cytokines, and Acute Toxicity.

Vogel CF, Chang WL, Kado S, McCulloh K, Vogel H, Wu D, Haarmann-Stemmann T, Yang G, Leung PS, Matsumura F, Gershwin ME.

Environ Health Perspect. 2016 Jul;124(7):1071-83. doi: 10.1289/ehp.1510194. Epub 2016 Feb 5.


Cobaltous chloride and hypoxia inhibit aryl hydrocarbon receptor-mediated responses in breast cancer cells.

Khan S, Liu S, Stoner M, Safe S.

Toxicol Appl Pharmacol. 2007 Aug 15;223(1):28-38. Epub 2007 May 25.


Aryl hydrocarbon receptor and aryl hydrocarbon nuclear translocator expression in human and rat placentas and transcription activity in human trophoblast cultures.

Stejskalova L, Vecerova L, Peréz LM, Vrzal R, Dvorak Z, Nachtigal P, Pavek P.

Toxicol Sci. 2011 Sep;123(1):26-36. doi: 10.1093/toxsci/kfr150. Epub 2011 Jun 10.


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