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Items: 1 to 20 of 116

1.

Amplified Detection of Prions and Other Amyloids by RT-QuIC in Diagnostics and the Evaluation of Therapeutics and Disinfectants.

Caughey B, Orru CD, Groveman BR, Hughson AG, Manca M, Raymond LD, Raymond GJ, Race B, Saijo E, Kraus A.

Prog Mol Biol Transl Sci. 2017;150:375-388. doi: 10.1016/bs.pmbts.2017.06.003. Epub 2017 Jul 27. Review.

PMID:
28838670
2.

RT-QuIC Assays for Prion Disease Detection and Diagnostics.

Orrù CD, Groveman BR, Hughson AG, Manca M, Raymond LD, Raymond GJ, Campbell KJ, Anson KJ, Kraus A, Caughey B.

Methods Mol Biol. 2017;1658:185-203. doi: 10.1007/978-1-4939-7244-9_14.

PMID:
28861791
3.

Ultrasensitive RT-QuIC Seed Amplification Assays for Disease-Associated Tau, α-Synuclein, and Prion Aggregates.

Saijo E, Groveman BR, Kraus A, Metrick M, Orrù CD, Hughson AG, Caughey B.

Methods Mol Biol. 2019;1873:19-37. doi: 10.1007/978-1-4939-8820-4_2.

PMID:
30341601
4.

Early detection of abnormal prion protein in genetic human prion diseases now possible using real-time QUIC assay.

Sano K, Satoh K, Atarashi R, Takashima H, Iwasaki Y, Yoshida M, Sanjo N, Murai H, Mizusawa H, Schmitz M, Zerr I, Kim YS, Nishida N.

PLoS One. 2013;8(1):e54915. doi: 10.1371/journal.pone.0054915. Epub 2013 Jan 25.

5.

Rapid end-point quantitation of prion seeding activity with sensitivity comparable to bioassays.

Wilham JM, Orrú CD, Bessen RA, Atarashi R, Sano K, Race B, Meade-White KD, Taubner LM, Timmes A, Caughey B.

PLoS Pathog. 2010 Dec 2;6(12):e1001217. doi: 10.1371/journal.ppat.1001217.

6.

Exploring physical and chemical factors influencing the properties of recombinant prion protein and the real-time quaking-induced conversion (RT-QuIC) assay.

Cheng K, Sloan A, Avery KM, Coulthart M, Carpenter M, Knox JD.

PLoS One. 2014 Jan 3;9(1):e84812. doi: 10.1371/journal.pone.0084812. eCollection 2014.

7.

Rapid and sensitive RT-QuIC detection of human Creutzfeldt-Jakob disease using cerebrospinal fluid.

Orrú CD, Groveman BR, Hughson AG, Zanusso G, Coulthart MB, Caughey B.

MBio. 2015 Jan 20;6(1). pii: e02451-14. doi: 10.1128/mBio.02451-14.

8.

A test for Creutzfeldt-Jakob disease using nasal brushings.

Orrú CD, Bongianni M, Tonoli G, Ferrari S, Hughson AG, Groveman BR, Fiorini M, Pocchiari M, Monaco S, Caughey B, Zanusso G.

N Engl J Med. 2014 Aug 7;371(6):519-29. doi: 10.1056/NEJMoa1315200. Erratum in: N Engl J Med. 2014 Nov 6;371(19):1852.

9.

Prion disease blood test using immunoprecipitation and improved quaking-induced conversion.

Orrú CD, Wilham JM, Raymond LD, Kuhn F, Schroeder B, Raeber AJ, Caughey B.

MBio. 2011 May 10;2(3):e00078-11. doi: 10.1128/mBio.00078-11. Print 2011.

10.

New generation QuIC assays for prion seeding activity.

Orrù CD, Wilham JM, Vascellari S, Hughson AG, Caughey B.

Prion. 2012 Apr-Jun;6(2):147-52. doi: 10.4161/pri.19430. Epub 2012 Apr 1. Review.

PMID:
22421206
11.

Prion Seeds Distribute throughout the Eyes of Sporadic Creutzfeldt-Jakob Disease Patients.

Orrù CD, Soldau K, Cordano C, Llibre-Guerra J, Green AJ, Sanchez H, Groveman BR, Edland SD, Safar JG, Lin JH, Caughey B, Geschwind MD, Sigurdson CJ.

MBio. 2018 Nov 20;9(6). pii: e02095-18. doi: 10.1128/mBio.02095-18.

12.

Diagnostic and prognostic value of human prion detection in cerebrospinal fluid.

Foutz A, Appleby BS, Hamlin C, Liu X, Yang S, Cohen Y, Chen W, Blevins J, Fausett C, Wang H, Gambetti P, Zhang S, Hughson A, Tatsuoka C, Schonberger LB, Cohen ML, Caughey B, Safar JG.

Ann Neurol. 2017 Jan;81(1):79-92. doi: 10.1002/ana.24833.

13.

Applications of the real-time quaking-induced conversion assay in diagnosis, prion strain-typing, drug pre-screening and other amyloidopathies.

Candelise N, Schmitz M, Da Silva Correia SM, Arora AS, Villar-Piqué A, Zafar S, Llorens F, Cramm M, Zerr I.

Expert Rev Mol Diagn. 2017 Oct;17(10):897-904. doi: 10.1080/14737159.2017.1368389. Epub 2017 Sep 8. Review.

PMID:
28817974
14.

Factors That Improve RT-QuIC Detection of Prion Seeding Activity.

Orrú CD, Hughson AG, Groveman BR, Campbell KJ, Anson KJ, Manca M, Kraus A, Caughey B.

Viruses. 2016 May 23;8(5). pii: E140. doi: 10.3390/v8050140.

15.

Prion seeding activities of mouse scrapie strains with divergent PrPSc protease sensitivities and amyloid plaque content using RT-QuIC and eQuIC.

Vascellari S, Orrù CD, Hughson AG, King D, Barron R, Wilham JM, Baron GS, Race B, Pani A, Caughey B.

PLoS One. 2012;7(11):e48969. doi: 10.1371/journal.pone.0048969. Epub 2012 Nov 5.

16.

Bank Vole Prion Protein As an Apparently Universal Substrate for RT-QuIC-Based Detection and Discrimination of Prion Strains.

Orrú CD, Groveman BR, Raymond LD, Hughson AG, Nonno R, Zou W, Ghetti B, Gambetti P, Caughey B.

PLoS Pathog. 2015 Jun 18;11(6):e1004983. doi: 10.1371/journal.ppat.1004983. eCollection 2015 Jun. Erratum in: PLoS Pathog. 2015 Aug;11(8):e1005117.

17.

Real-Time Quaking-Induced Conversion Analysis for the Diagnosis of Sporadic Creutzfeldt-Jakob Disease in Korea.

Park JH, Choi YG, Lee YJ, Park SJ, Choi HS, Choi KC, Choi EK, Kim YS.

J Clin Neurol. 2016 Jan;12(1):101-6. doi: 10.3988/jcn.2016.12.1.101. Epub 2015 Nov 4.

18.

The real-time quaking-induced conversion assay for detection of human prion disease and study of other protein misfolding diseases.

Schmitz M, Cramm M, Llorens F, Müller-Cramm D, Collins S, Atarashi R, Satoh K, Orrù CD, Groveman BR, Zafar S, Schulz-Schaeffer WJ, Caughey B, Zerr I.

Nat Protoc. 2016 Nov;11(11):2233-2242. doi: 10.1038/nprot.2016.120. Epub 2016 Oct 13.

PMID:
27735933
19.

Real-Time Quaking-Induced Conversion Detection of Bovine Spongiform Encephalopathy Prions in a Subclinical Steer.

Hwang S, West Greenlee MH, Balkema-Buschmann A, Groschup MH, Nicholson EM, Greenlee JJ.

Front Vet Sci. 2018 Jan 19;4:242. doi: 10.3389/fvets.2017.00242. eCollection 2017.

20.

Real-time Quaking-induced Conversion Assay for Detection of CWD Prions in Fecal Material.

Cheng YC, Hannaoui S, John TR, Dudas S, Czub S, Gilch S.

J Vis Exp. 2017 Sep 29;(127). doi: 10.3791/56373.

PMID:
28994814

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