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Items: 1 to 20 of 80

1.

Genetic regulatory effects modified by immune activation contribute to autoimmune disease associations.

Kim-Hellmuth S, Bechheim M, Pütz B, Mohammadi P, Nédélec Y, Giangreco N, Becker J, Kaiser V, Fricker N, Beier E, Boor P, Castel SE, Nöthen MM, Barreiro LB, Pickrell JK, Müller-Myhsok B, Lappalainen T, Schumacher J, Hornung V.

Nat Commun. 2017 Aug 16;8(1):266. doi: 10.1038/s41467-017-00366-1.

2.

Limited statistical evidence for shared genetic effects of eQTLs and autoimmune-disease-associated loci in three major immune-cell types.

Chun S, Casparino A, Patsopoulos NA, Croteau-Chonka DC, Raby BA, De Jager PL, Sunyaev SR, Cotsapas C.

Nat Genet. 2017 Apr;49(4):600-605. doi: 10.1038/ng.3795. Epub 2017 Feb 20.

3.

CARD15 variants determine a disturbed early response of monocytes to adherent-invasive Escherichia coli strain LF82 in Crohn's disease.

Peeters H, Bogaert S, Laukens D, Rottiers P, De Keyser F, Darfeuille-Michaud A, Glasser AL, Elewaut D, De Vos M.

Int J Immunogenet. 2007 Jun;34(3):181-91.

PMID:
17504508
4.

Integrative modeling of eQTLs and cis-regulatory elements suggests mechanisms underlying cell type specificity of eQTLs.

Brown CD, Mangravite LM, Engelhardt BE.

PLoS Genet. 2013;9(8):e1003649. doi: 10.1371/journal.pgen.1003649. Epub 2013 Aug 1.

5.

Insight into Genotype-Phenotype Associations through eQTL Mapping in Multiple Cell Types in Health and Immune-Mediated Disease.

Peters JE, Lyons PA, Lee JC, Richard AC, Fortune MD, Newcombe PJ, Richardson S, Smith KG.

PLoS Genet. 2016 Mar 25;12(3):e1005908. doi: 10.1371/journal.pgen.1005908. eCollection 2016 Mar.

6.

Targeted genomic analysis reveals widespread autoimmune disease association with regulatory variants in the TNF superfamily cytokine signalling network.

Richard AC, Peters JE, Lee JC, Vahedi G, Schäffer AA, Siegel RM, Lyons PA, Smith KG.

Genome Med. 2016 Jul 19;8(1):76. doi: 10.1186/s13073-016-0329-5.

7.

Powerful identification of cis-regulatory SNPs in human primary monocytes using allele-specific gene expression.

Almlöf JC, Lundmark P, Lundmark A, Ge B, Maouche S, Göring HH, Liljedahl U, Enström C, Brocheton J, Proust C, Godefroy T, Sambrook JG, Jolley J, Crisp-Hihn A, Foad N, Lloyd-Jones H, Stephens J, Gwilliam R, Rice CM, Hengstenberg C, Samani NJ, Erdmann J, Schunkert H, Pastinen T, Deloukas P, Goodall AH, Ouwehand WH, Cambien F, Syvänen AC.

PLoS One. 2012;7(12):e52260. doi: 10.1371/journal.pone.0052260. Epub 2012 Dec 26.

8.

Patterns of Transcriptional Response to 1,25-Dihydroxyvitamin D3 and Bacterial Lipopolysaccharide in Primary Human Monocytes.

Kariuki SN, Blischak JD, Nakagome S, Witonsky DB, Di Rienzo A.

G3 (Bethesda). 2016 May 3;6(5):1345-55. doi: 10.1534/g3.116.028712.

9.

Effects of a bacterial cell wall fragment on monocyte inflammatory function.

Safavi KE, Nichols FC.

J Endod. 2000 Mar;26(3):153-5.

PMID:
11199709
10.
11.

Innate immune activity conditions the effect of regulatory variants upon monocyte gene expression.

Fairfax BP, Humburg P, Makino S, Naranbhai V, Wong D, Lau E, Jostins L, Plant K, Andrews R, McGee C, Knight JC.

Science. 2014 Mar 7;343(6175):1246949. doi: 10.1126/science.1246949.

12.

Integrated genome-wide analysis of expression quantitative trait loci aids interpretation of genomic association studies.

Joehanes R, Zhang X, Huan T, Yao C, Ying SX, Nguyen QT, Demirkale CY, Feolo ML, Sharopova NR, Sturcke A, Schäffer AA, Heard-Costa N, Chen H, Liu PC, Wang R, Woodhouse KA, Tanriverdi K, Freedman JE, Raghavachari N, Dupuis J, Johnson AD, O'Donnell CJ, Levy D, Munson PJ.

Genome Biol. 2017 Jan 25;18(1):16. doi: 10.1186/s13059-016-1142-6.

13.

Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes.

Raj T, Rothamel K, Mostafavi S, Ye C, Lee MN, Replogle JM, Feng T, Lee M, Asinovski N, Frohlich I, Imboywa S, Von Korff A, Okada Y, Patsopoulos NA, Davis S, McCabe C, Paik HI, Srivastava GP, Raychaudhuri S, Hafler DA, Koller D, Regev A, Hacohen N, Mathis D, Benoist C, Stranger BE, De Jager PL.

Science. 2014 May 2;344(6183):519-23. doi: 10.1126/science.1249547.

14.

Impact of genetic risk loci for multiple sclerosis on expression of proximal genes in patients.

James T, Lindén M, Morikawa H, Fernandes SJ, Ruhrmann S, Huss M, Brandi M, Piehl F, Jagodic M, Tegnér J, Khademi M, Olsson T, Gomez-Cabrero D, Kockum I.

Hum Mol Genet. 2018 Mar 1;27(5):912-928. doi: 10.1093/hmg/ddy001.

PMID:
29325110
15.

Generation of primary human intestinal T cell transcriptomes reveals differential expression at genetic risk loci for immune-mediated disease.

Raine T, Liu JZ, Anderson CA, Parkes M, Kaser A.

Gut. 2015 Feb;64(2):250-9. doi: 10.1136/gutjnl-2013-306657. Epub 2014 May 5.

16.

Synthesis of 53 tissue and cell line expression QTL datasets reveals master eQTLs.

Zhang X, Gierman HJ, Levy D, Plump A, Dobrin R, Goring HH, Curran JE, Johnson MP, Blangero J, Kim SK, O'Donnell CJ, Emilsson V, Johnson AD.

BMC Genomics. 2014 Jun 27;15:532. doi: 10.1186/1471-2164-15-532.

17.

Airway Epithelial Expression Quantitative Trait Loci Reveal Genes Underlying Asthma and Other Airway Diseases.

Luo W, Obeidat M, Di Narzo AF, Chen R, Sin DD, Paré PD, Hao K.

Am J Respir Cell Mol Biol. 2016 Feb;54(2):177-87. doi: 10.1165/rcmb.2014-0381OC.

18.

MAIL regulates human monocyte IL-6 production.

Seshadri S, Kannan Y, Mitra S, Parker-Barnes J, Wewers MD.

J Immunol. 2009 Oct 15;183(8):5358-68. doi: 10.4049/jimmunol.0802736. Epub 2009 Sep 25.

19.

The genetic regulation of transcription in human endometrial tissue.

Fung JN, Girling JE, Lukowski SW, Sapkota Y, Wallace L, Holdsworth-Carson SJ, Henders AK, Healey M, Rogers PAW, Powell JE, Montgomery GW.

Hum Reprod. 2017 Apr 1;32(4):893-904. doi: 10.1093/humrep/dex006.

PMID:
28177073
20.

Regulation of gene expression in autoimmune disease loci and the genetic basis of proliferation in CD4+ effector memory T cells.

Hu X, Kim H, Raj T, Brennan PJ, Trynka G, Teslovich N, Slowikowski K, Chen WM, Onengut S, Baecher-Allan C, De Jager PL, Rich SS, Stranger BE, Brenner MB, Raychaudhuri S.

PLoS Genet. 2014 Jun 26;10(6):e1004404. doi: 10.1371/journal.pgen.1004404. eCollection 2014 Jun.

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