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Extracellular Vesicles Transfer the Receptor Programmed Death-1 in Rheumatoid Arthritis.

Greisen SR, Yan Y, Hansen AS, Venø MT, Nyengaard JR, Moestrup SK, Hvid M, Freeman GJ, Kjems J, Deleuran B.

Front Immunol. 2017 Jul 24;8:851. doi: 10.3389/fimmu.2017.00851. eCollection 2017.


Specificity of T cells in synovial fluid: high frequencies of CD8(+) T cells that are specific for certain viral epitopes.

Tan LC, Mowat AG, Fazou C, Rostron T, Roskell H, Dunbar PR, Tournay C, Romagné F, Peyrat MA, Houssaint E, Bonneville M, Rickinson AB, McMichael AJ, Callan MF.

Arthritis Res. 2000;2(2):154-64. Epub 2000 Feb 7.


The programmed death 1/programmed death ligand 1 inhibitory pathway is up-regulated in rheumatoid synovium and regulates peripheral T cell responses in human and murine arthritis.

Raptopoulou AP, Bertsias G, Makrygiannakis D, Verginis P, Kritikos I, Tzardi M, Klareskog L, Catrina AI, Sidiropoulos P, Boumpas DT.

Arthritis Rheum. 2010 Jul;62(7):1870-80. doi: 10.1002/art.27500.


Increased Expression and Modulated Regulatory Activity of Coinhibitory Receptors PD-1, TIGIT, and TIM-3 in Lymphocytes From Patients With Systemic Sclerosis.

Fleury M, Belkina AC, Proctor EA, Zammitti C, Simms RW, Lauffenburger DA, Snyder-Cappione JE, Lafyatis R, Dooms H.

Arthritis Rheumatol. 2018 Apr;70(4):566-577. doi: 10.1002/art.40399. Epub 2018 Mar 7.


Extracellular vesicles in the pathogenesis of rheumatoid arthritis and osteoarthritis.

Withrow J, Murphy C, Liu Y, Hunter M, Fulzele S, Hamrick MW.

Arthritis Res Ther. 2016 Dec 1;18(1):286. Review.


Blockade of Toll-like receptor 2 prevents spontaneous cytokine release from rheumatoid arthritis ex vivo synovial explant cultures.

Ultaigh SN, Saber TP, McCormick J, Connolly M, Dellacasagrande J, Keogh B, McCormack W, Reilly M, O'Neill LA, McGuirk P, Fearon U, Veale DJ.

Arthritis Res Ther. 2011 Feb 23;13(1):R33. doi: 10.1186/ar3261.


Expression of IL-10 family cytokines in rheumatoid arthritis: elevated levels of IL-19 in the joints.

Alanärä T, Karstila K, Moilanen T, Silvennoinen O, Isomäki P.

Scand J Rheumatol. 2010 Mar;39(2):118-26. doi: 10.3109/03009740903170823.


A regulatory effect of IL-21 on T follicular helper-like cell and B cell in rheumatoid arthritis.

Liu R, Wu Q, Su D, Che N, Chen H, Geng L, Chen J, Chen W, Li X, Sun L.

Arthritis Res Ther. 2012 Nov 23;14(6):R255. doi: 10.1186/ar4100.


Correlation of low CD73 expression on synovial lymphocytes with reduced adenosine generation and higher disease severity in juvenile idiopathic arthritis.

Botta Gordon-Smith S, Ursu S, Eaton S, Moncrieffe H, Wedderburn LR.

Arthritis Rheumatol. 2015 Feb;67(2):545-54. doi: 10.1002/art.38959.


Discrepancy in T cell clonal expansions in synovial fluid and peripheral blood from rheumatoid arthritis patients.

Choi IH, Chwae Y, Lee SK, Chu M, Kim JD, Kim SJ.

Yonsei Med J. 1995 Mar;36(1):68-76.


TIGIT overexpression diminishes the function of CD4 T cells and ameliorates the severity of rheumatoid arthritis in mouse models.

Zhao W, Dong Y, Wu C, Ma Y, Jin Y, Ji Y.

Exp Cell Res. 2016 Jan 1;340(1):132-8. doi: 10.1016/j.yexcr.2015.12.002. Epub 2015 Dec 9.


Synovial T cell hyporesponsiveness to myeloid dendritic cells is reversed by preventing PD-1/PD-L1 interactions.

Moret FM, van der Wurff-Jacobs KM, Bijlsma JW, Lafeber FP, van Roon JA.

Arthritis Res Ther. 2014 Nov 30;16(6):497. doi: 10.1186/s13075-014-0497-x.


Lymphocytes and synovial fluid fibroblasts support osteoclastogenesis through RANKL, TNFalpha, and IL-7 in an in vitro model derived from human psoriatic arthritis.

Colucci S, Brunetti G, Cantatore FP, Oranger A, Mori G, Quarta L, Cirulli N, Mancini L, Corrado A, Grassi FR, Grano M.

J Pathol. 2007 May;212(1):47-55.


CD4+ PD-1+ T cells accumulate as unique anergic cells in rheumatoid arthritis synovial fluid.

Hatachi S, Iwai Y, Kawano S, Morinobu S, Kobayashi M, Koshiba M, Saura R, Kurosaka M, Honjo T, Kumagai S.

J Rheumatol. 2003 Jul;30(7):1410-9.


Increased intra-articular granzyme M may trigger local IFN-λ1/IL-29 response in rheumatoid arthritis.

Shan L, van den Hoogen LL, Meeldijk J, Kok HM, Jongeneel LH, Boes M, Wenink MH, Hack CE, Radstake TRDJ, van Roon JAG, Bovenschen N.

Clin Exp Rheumatol. 2019 Jun 6. [Epub ahead of print]


[Expression of CCR5 and its ligand in joint fluid and synovium of patients with rheumatoid arthritis].

Zhu P, Wang Y, Fan C.

Zhonghua Yi Xue Za Zhi. 2001 Sep 10;81(17):1038-41. Chinese.


Increased soluble programmed death-1 (sPD-1) is associated with disease activity and radiographic progression in early rheumatoid arthritis.

Greisen SR, Rasmussen TK, Stengaard-Pedersen K, Hetland ML, Hørslev-Petersen K, Hvid M, Deleuran B.

Scand J Rheumatol. 2014;43(2):101-8. doi: 10.3109/03009742.2013.823517. Epub 2013 Nov 1.


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