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Items: 1 to 20 of 148

1.

SIRT1 activates the expression of fetal hemoglobin genes.

Dai Y, Chen T, Ijaz H, Cho EH, Steinberg MH.

Am J Hematol. 2017 Nov;92(11):1177-1186. doi: 10.1002/ajh.24879. Epub 2017 Aug 28.

2.

Inhibition of G9a methyltransferase stimulates fetal hemoglobin production by facilitating LCR/γ-globin looping.

Krivega I, Byrnes C, de Vasconcellos JF, Lee YT, Kaushal M, Dean A, Miller JL.

Blood. 2015 Jul 30;126(5):665-72. doi: 10.1182/blood-2015-02-629972. Epub 2015 May 15.

3.

Plastrum testudinis induces γ-globin gene expression through epigenetic histone modifications within the γ-globin gene promoter via activation of the p38 MAPK signaling pathway.

Qian X, Chen J, Zhao D, Guo L, Qian X.

Int J Mol Med. 2013 Jun;31(6):1418-28. doi: 10.3892/ijmm.2013.1338. Epub 2013 Apr 8.

PMID:
23588991
4.

HMGA2 Moderately Increases Fetal Hemoglobin Expression in Human Adult Erythroblasts.

de Vasconcellos JF, Lee YT, Byrnes C, Tumburu L, Rabel A, Miller JL.

PLoS One. 2016 Nov 18;11(11):e0166928. doi: 10.1371/journal.pone.0166928. eCollection 2016.

5.

Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A.

Sankaran VG, Menne TF, Xu J, Akie TE, Lettre G, Van Handel B, Mikkola HK, Hirschhorn JN, Cantor AB, Orkin SH.

Science. 2008 Dec 19;322(5909):1839-42. doi: 10.1126/science.1165409. Epub 2008 Dec 4.

6.

Quantification of HBG mRNA in primary erythroid cultures: prediction of the response to hydroxyurea in sickle cell and beta-thalassemia.

Pecoraro A, Rigano P, Troia A, Calzolari R, Scazzone C, Maggio A, Steinberg MH, Di Marzo R.

Eur J Haematol. 2014 Jan;92(1):66-72. doi: 10.1111/ejh.12204. Epub 2013 Oct 22.

PMID:
24112139
7.

A zinc-finger transcriptional activator designed to interact with the gamma-globin gene promoters enhances fetal hemoglobin production in primary human adult erythroblasts.

Wilber A, Tschulena U, Hargrove PW, Kim YS, Persons DA, Barbas CF 3rd, Nienhuis AW.

Blood. 2010 Apr 15;115(15):3033-41. doi: 10.1182/blood-2009-08-240556. Epub 2010 Feb 26.

8.

Erythroid-Specific Expression of LIN28A Is Sufficient for Robust Gamma-Globin Gene and Protein Expression in Adult Erythroblasts.

Lee YT, de Vasconcellos JF, Byrnes C, Kaushal M, Rabel A, Tumburu L, Allwardt JM, Miller JL.

PLoS One. 2015 Dec 16;10(12):e0144977. doi: 10.1371/journal.pone.0144977. eCollection 2015.

9.

Identification of fetal hemoglobin-inducing agents using the human leukemia KU812 cell line.

Zein S, Li W, Ramakrishnan V, Lou TF, Sivanand S, Mackie A, Pace B.

Exp Biol Med (Maywood). 2010 Nov;235(11):1385-94. doi: 10.1258/ebm.2010.010129.

PMID:
20975082
10.

Pharmacological Induction of Human Fetal Globin Gene in Hydroxyurea-Resistant Primary Adult Erythroid Cells.

Chou YC, Chen RL, Lai ZS, Song JS, Chao YS, Shen CK.

Mol Cell Biol. 2015 Jul;35(14):2541-53. doi: 10.1128/MCB.00035-15. Epub 2015 May 18.

11.

Krüppel-like Factor 4 activates HBG gene expression in primary erythroid cells.

Kalra IS, Alam MM, Choudhary PK, Pace BS.

Br J Haematol. 2011 Jul;154(2):248-59. doi: 10.1111/j.1365-2141.2011.08710.x. Epub 2011 May 3.

12.

Mi2β-mediated silencing of the fetal γ-globin gene in adult erythroid cells.

Amaya M, Desai M, Gnanapragasam MN, Wang SZ, Zu Zhu S, Williams DC Jr, Ginder GD.

Blood. 2013 Apr 25;121(17):3493-501. doi: 10.1182/blood-2012-11-466227. Epub 2013 Feb 26.

13.

Krüppel-Like Transcription Factor KLF1 Is Required for Optimal γ- and β-Globin Expression in Human Fetal Erythroblasts.

Vinjamur DS, Alhashem YN, Mohamad SF, Amin P, Williams DC Jr, Lloyd JA.

PLoS One. 2016 Feb 3;11(2):e0146802. doi: 10.1371/journal.pone.0146802. eCollection 2016.

14.

Induction of human fetal hemoglobin via the NRF2 antioxidant response signaling pathway.

Macari ER, Lowrey CH.

Blood. 2011 Jun 2;117(22):5987-97. doi: 10.1182/blood-2010-10-314096. Epub 2011 Apr 4.

15.

Compounds of the anthracycline family of antibiotics elevate human gamma-globin expression both in erythroid cultures and in a transgenic mouse model.

Spyrou P, Phylactides M, Lederer CW, Kithreotis L, Kirri A, Christou S, Kkolou E, Kanavakis E, Anagnou NP, Stamatoyannopoulos G, Kleanthous M.

Blood Cells Mol Dis. 2010 Mar-Apr;44(2):100-6. doi: 10.1016/j.bcmd.2009.10.008. Epub 2009 Nov 14.

PMID:
19914848
16.

Therapeutic levels of fetal hemoglobin in erythroid progeny of β-thalassemic CD34+ cells after lentiviral vector-mediated gene transfer.

Wilber A, Hargrove PW, Kim YS, Riberdy JM, Sankaran VG, Papanikolaou E, Georgomanoli M, Anagnou NP, Orkin SH, Nienhuis AW, Persons DA.

Blood. 2011 Mar 10;117(10):2817-26. doi: 10.1182/blood-2010-08-300723. Epub 2010 Dec 14.

17.

Cis-vaccenic acid induces differentiation and up-regulates gamma globin synthesis in K562, JK1 and transgenic mice erythroid progenitor stem cells.

Aimola IA, Inuwa HM, Nok AJ, Mamman AI, Bieker JJ.

Eur J Pharmacol. 2016 Apr 5;776:9-18. doi: 10.1016/j.ejphar.2016.02.041. Epub 2016 Feb 12.

18.

Resveratrol: Antioxidant activity and induction of fetal hemoglobin in erythroid cells from normal donors and β-thalassemia patients.

Fibach E, Prus E, Bianchi N, Zuccato C, Breveglieri G, Salvatori F, Finotti A, Lipucci di Paola M, Brognara E, Lampronti I, Borgatti M, Gambari R.

Int J Mol Med. 2012 Jun;29(6):974-82. doi: 10.3892/ijmm.2012.928. Epub 2012 Feb 28.

PMID:
22378234
19.

Transcriptional activation of the gamma-globin gene in baboons treated with decitabine and in cultured erythroid progenitor cells involves different mechanisms.

Chin J, Singh M, Banzon V, Vaitkus K, Ibanez V, Kouznetsova T, Mahmud N, DeSimone J, Lavelle D.

Exp Hematol. 2009 Oct;37(10):1131-42. doi: 10.1016/j.exphem.2009.06.007. Epub 2009 Jul 2.

PMID:
19576949
20.

Transcriptional regulators Myb and BCL11A interplay with DNA methyltransferase 1 in developmental silencing of embryonic and fetal β-like globin genes.

Roosjen M, McColl B, Kao B, Gearing LJ, Blewitt ME, Vadolas J.

FASEB J. 2014 Apr;28(4):1610-20. doi: 10.1096/fj.13-242669. Epub 2013 Dec 26.

PMID:
24371119

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