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Items: 1 to 20 of 101

1.

The link between exercise and titin passive stiffness.

Lalande S, Mueller PJ, Chung CS.

Exp Physiol. 2017 Sep 1;102(9):1055-1066. doi: 10.1113/EP086275. Epub 2017 Jul 31. Review.

2.
3.

Increased myocardial stiffness due to cardiac titin isoform switching in a mouse model of volume overload limits eccentric remodeling.

Hutchinson KR, Saripalli C, Chung CS, Granzier H.

J Mol Cell Cardiol. 2015 Feb;79:104-14. doi: 10.1016/j.yjmcc.2014.10.020. Epub 2014 Nov 8.

4.

Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy.

Nagueh SF, Shah G, Wu Y, Torre-Amione G, King NM, Lahmers S, Witt CC, Becker K, Labeit S, Granzier HL.

Circulation. 2004 Jul 13;110(2):155-62. Epub 2004 Jul 6.

PMID:
15238456
5.

Effect of exercise training on post-translational and post-transcriptional regulation of titin stiffness in striated muscle of wild type and IG KO mice.

Hidalgo C, Saripalli C, Granzier HL.

Arch Biochem Biophys. 2014 Jun 15;552-553:100-7. doi: 10.1016/j.abb.2014.02.010. Epub 2014 Mar 3.

PMID:
24603287
6.

Titin-based tension in the cardiac sarcomere: molecular origin and physiological adaptations.

Anderson BR, Granzier HL.

Prog Biophys Mol Biol. 2012 Oct-Nov;110(2-3):204-17. doi: 10.1016/j.pbiomolbio.2012.08.003. Epub 2012 Aug 11. Review.

7.

Effect of exercise on passive myocardial stiffness in mice with diastolic dysfunction.

Slater RE, Strom JG, Granzier H.

J Mol Cell Cardiol. 2017 Jul;108:24-33. doi: 10.1016/j.yjmcc.2017.04.006. Epub 2017 May 3.

PMID:
28476659
8.

Hyperphosphorylation of mouse cardiac titin contributes to transverse aortic constriction-induced diastolic dysfunction.

Hudson B, Hidalgo C, Saripalli C, Granzier H.

Circ Res. 2011 Sep 30;109(8):858-66. doi: 10.1161/CIRCRESAHA.111.246819. Epub 2011 Aug 11.

9.

Tuning the molecular giant titin through phosphorylation: role in health and disease.

Hidalgo C, Granzier H.

Trends Cardiovasc Med. 2013 Jul;23(5):165-71. doi: 10.1016/j.tcm.2012.10.005. Epub 2013 Jan 5. Review.

10.

Passive stiffness of myocardium from congenital heart disease and implications for diastole.

Chaturvedi RR, Herron T, Simmons R, Shore D, Kumar P, Sethia B, Chua F, Vassiliadis E, Kentish JC.

Circulation. 2010 Mar 2;121(8):979-88. doi: 10.1161/CIRCULATIONAHA.109.850677. Epub 2010 Feb 16.

PMID:
20159832
11.

Changes in titin and collagen underlie diastolic stiffness diversity of cardiac muscle.

Wu Y, Cazorla O, Labeit D, Labeit S, Granzier H.

J Mol Cell Cardiol. 2000 Dec;32(12):2151-62.

PMID:
11112991
12.

Alternative Splicing of Titin Restores Diastolic Function in an HFpEF-Like Genetic Murine Model (TtnΔIAjxn).

Bull M, Methawasin M, Strom J, Nair P, Hutchinson K, Granzier H.

Circ Res. 2016 Sep 2;119(6):764-72. doi: 10.1161/CIRCRESAHA.116.308904. Epub 2016 Jul 28.

13.

Differential changes in titin domain phosphorylation increase myofilament stiffness in failing human hearts.

Kötter S, Gout L, Von Frieling-Salewsky M, Müller AE, Helling S, Marcus K, Dos Remedios C, Linke WA, Krüger M.

Cardiovasc Res. 2013 Sep 1;99(4):648-56. doi: 10.1093/cvr/cvt144. Epub 2013 Jun 13.

PMID:
23764881
14.

Protein kinase-A phosphorylates titin in human heart muscle and reduces myofibrillar passive tension.

Krüger M, Linke WA.

J Muscle Res Cell Motil. 2006;27(5-7):435-44. Epub 2006 Aug 4.

PMID:
16897574
15.

Diabetes-Induced Cardiomyocyte Passive Stiffening Is Caused by Impaired Insulin-Dependent Titin Modification and Can Be Modulated by Neuregulin-1.

Hopf AE, Andresen C, Kötter S, Isić M, Ulrich K, Sahin S, Bongardt S, Röll W, Drove F, Scheerer N, Vandekerckhove L, De Keulenaer GW, Hamdani N, Linke WA, Krüger M.

Circ Res. 2018 Jul 20;123(3):342-355. doi: 10.1161/CIRCRESAHA.117.312166. Epub 2018 May 14.

PMID:
29760016
16.

Protein kinase G modulates human myocardial passive stiffness by phosphorylation of the titin springs.

Krüger M, Kötter S, Grützner A, Lang P, Andresen C, Redfield MM, Butt E, dos Remedios CG, Linke WA.

Circ Res. 2009 Jan 2;104(1):87-94. doi: 10.1161/CIRCRESAHA.108.184408. Epub 2008 Nov 20.

PMID:
19023132
17.
18.

Hypothyroidism leads to increased collagen-based stiffness and re-expression of large cardiac titin isoforms with high compliance.

Wu Y, Peng J, Campbell KB, Labeit S, Granzier H.

J Mol Cell Cardiol. 2007 Jan;42(1):186-95. Epub 2006 Oct 27.

PMID:
17069849
19.

Titin isoform switching is a major cardiac adaptive response in hibernating grizzly bears.

Nelson OL, Robbins CT, Wu Y, Granzier H.

Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H366-71. doi: 10.1152/ajpheart.00234.2008. Epub 2008 May 23.

20.

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