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Items: 1 to 20 of 161

1.

How Ligands Illuminate GPCR Molecular Pharmacology.

Wacker D, Stevens RC, Roth BL.

Cell. 2017 Jul 27;170(3):414-427. doi: 10.1016/j.cell.2017.07.009. Review.

2.

Emerging structural insights into biased GPCR signaling.

Shukla AK, Singh G, Ghosh E.

Trends Biochem Sci. 2014 Dec;39(12):594-602. doi: 10.1016/j.tibs.2014.10.001. Epub 2014 Nov 4. Review.

PMID:
25458114
3.

Tuning up the right signal: chemical and genetic approaches to study GPCR functions.

Giguere PM, Kroeze WK, Roth BL.

Curr Opin Cell Biol. 2014 Apr;27:51-5. doi: 10.1016/j.ceb.2013.11.006. Epub 2013 Dec 8. Review.

4.

Discovery of new GPCR ligands to illuminate new biology.

Roth BL, Irwin JJ, Shoichet BK.

Nat Chem Biol. 2017 Nov;13(11):1143-1151. doi: 10.1038/nchembio.2490. Epub 2017 Oct 18.

5.

Bridging the gap: bitopic ligands of G-protein-coupled receptors.

Lane JR, Sexton PM, Christopoulos A.

Trends Pharmacol Sci. 2013 Jan;34(1):59-66. doi: 10.1016/j.tips.2012.10.003. Epub 2012 Nov 20. Review.

PMID:
23177916
6.

Emerging paradigms in GPCR allostery: implications for drug discovery.

Wootten D, Christopoulos A, Sexton PM.

Nat Rev Drug Discov. 2013 Aug;12(8):630-44. doi: 10.1038/nrd4052. Review.

PMID:
23903222
7.

Structural insights into ligand recognition and selectivity for classes A, B, and C GPCRs.

Lee SM, Booe JM, Pioszak AA.

Eur J Pharmacol. 2015 Sep 15;763(Pt B):196-205. doi: 10.1016/j.ejphar.2015.05.013. Epub 2015 May 14. Review.

8.

G-protein coupled receptors: advances in simulation and drug discovery.

Miao Y, McCammon JA.

Curr Opin Struct Biol. 2016 Dec;41:83-89. doi: 10.1016/j.sbi.2016.06.008. Epub 2016 Jun 22. Review.

9.

Using silico methods predicting ligands for orphan GPCRs.

Jiang Z, Zhou Y.

Curr Protein Pept Sci. 2006 Oct;7(5):459-64. Review.

PMID:
17073696
10.

Emerging Approaches to GPCR Ligand Screening for Drug Discovery.

Kumari P, Ghosh E, Shukla AK.

Trends Mol Med. 2015 Nov;21(11):687-701. doi: 10.1016/j.molmed.2015.09.002. Epub 2015 Oct 16. Review.

PMID:
26481827
11.

Quantitative and systems pharmacology 2. In silico polypharmacology of G protein-coupled receptor ligands via network-based approaches.

Wu Z, Lu W, Yu W, Wang T, Li W, Liu G, Zhang H, Pang X, Huang J, Liu M, Cheng F, Tang Y.

Pharmacol Res. 2018 Mar;129:400-413. doi: 10.1016/j.phrs.2017.11.005. Epub 2017 Nov 10.

PMID:
29133212
12.

Orphan G protein-coupled receptors (GPCRs): biological functions and potential drug targets.

Tang XL, Wang Y, Li DL, Luo J, Liu MY.

Acta Pharmacol Sin. 2012 Mar;33(3):363-71. doi: 10.1038/aps.2011.210. Epub 2012 Feb 27. Review.

13.

Advances in Computational Techniques to Study GPCR-Ligand Recognition.

Ciancetta A, Sabbadin D, Federico S, Spalluto G, Moro S.

Trends Pharmacol Sci. 2015 Dec;36(12):878-890. doi: 10.1016/j.tips.2015.08.006. Epub 2015 Nov 1. Review.

PMID:
26538318
14.

Employing novel animal models in the design of clinically efficacious GPCR ligands.

Bradley SJ, Riaz SA, Tobin AB.

Curr Opin Cell Biol. 2014 Apr;27:117-25. doi: 10.1016/j.ceb.2013.12.002. Epub 2013 Dec 31. Review.

15.

G protein-coupled receptor transmembrane binding pockets and their applications in GPCR research and drug discovery: a survey.

Kratochwil NA, Gatti-McArthur S, Hoener MC, Lindemann L, Christ AD, Green LG, Guba W, Martin RE, Malherbe P, Porter RH, Slack JP, Winnig M, Dehmlow H, Grether U, Hertel C, Narquizian R, Panousis CG, Kolczewski S, Steward L.

Curr Top Med Chem. 2011;11(15):1902-24.

PMID:
21470172
16.

Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate Receptors.

Lindsley CW, Emmitte KA, Hopkins CR, Bridges TM, Gregory KJ, Niswender CM, Conn PJ.

Chem Rev. 2016 Jun 8;116(11):6707-41. doi: 10.1021/acs.chemrev.5b00656. Epub 2016 Feb 16. Review.

17.

Biased ligands for better cardiovascular drugs: dissecting G-protein-coupled receptor pharmacology.

DeWire SM, Violin JD.

Circ Res. 2011 Jul 8;109(2):205-16. doi: 10.1161/CIRCRESAHA.110.231308. Review.

PMID:
21737816
18.

Do orphan G-protein-coupled receptors have ligand-independent functions? New insights from receptor heterodimers.

Levoye A, Dam J, Ayoub MA, Guillaume JL, Jockers R.

EMBO Rep. 2006 Nov;7(11):1094-8. Review.

19.

Orphan receptor ligand discovery by pickpocketing pharmacological neighbors.

Ngo T, Ilatovskiy AV, Stewart AG, Coleman JL, McRobb FM, Riek RP, Graham RM, Abagyan R, Kufareva I, Smith NJ.

Nat Chem Biol. 2017 Feb;13(2):235-242. doi: 10.1038/nchembio.2266. Epub 2016 Dec 19.

20.

Selective GPCR ligands.

Gmeiner P.

Bioorg Med Chem. 2015 Jul 15;23(14):3879. doi: 10.1016/j.bmc.2015.03.030. Epub 2015 Mar 14. No abstract available.

PMID:
25818769

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