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Items: 1 to 20 of 126

1.

The E3 ubiquitin ligase NEDD4 induces endocytosis and lysosomal sorting of connexin 43 to promote loss of gap junctions.

Totland MZ, Bergsland CH, Fykerud TA, Knudsen LM, Rasmussen NL, Eide PW, Yohannes Z, Sørensen V, Brech A, Lothe RA, Leithe E.

J Cell Sci. 2017 Sep 1;130(17):2867-2882. doi: 10.1242/jcs.202408. Epub 2017 Jul 21.

2.

Ubiquitination of gap junction proteins.

Leithe E, Rivedal E.

J Membr Biol. 2007 Jun;217(1-3):43-51. Epub 2007 Jul 28. Review.

PMID:
17657522
3.

Regulation of connexins by the ubiquitin system: Implications for intercellular communication and cancer.

Leithe E.

Biochim Biophys Acta. 2016 Apr;1865(2):133-46. doi: 10.1016/j.bbcan.2016.02.001. Epub 2016 Feb 12. Review.

PMID:
26855059
4.

Smad ubiquitination regulatory factor-2 controls gap junction intercellular communication by modulating endocytosis and degradation of connexin43.

Fykerud TA, Kjenseth A, Schink KO, Sirnes S, Bruun J, Omori Y, Brech A, Rivedal E, Leithe E.

J Cell Sci. 2012 Sep 1;125(Pt 17):3966-76. doi: 10.1242/jcs.093500. Epub 2012 May 23.

5.

Ubiquitylation of the gap junction protein connexin-43 signals its trafficking from early endosomes to lysosomes in a process mediated by Hrs and Tsg101.

Leithe E, Kjenseth A, Sirnes S, Stenmark H, Brech A, Rivedal E.

J Cell Sci. 2009 Nov 1;122(Pt 21):3883-93. doi: 10.1242/jcs.053801. Epub 2009 Oct 6.

6.

CRTC2 and Nedd4 ligase involvement in FSH and TGFβ1 upregulation of connexin43 gap junction.

Fang WL, Lai SY, Lai WA, Lee MT, Liao CF, Ke FC, Hwang JJ.

J Mol Endocrinol. 2015 Dec;55(3):263-75. doi: 10.1530/JME-15-0076.

PMID:
26508620
7.
8.

Nedd4-interacting protein 2, a short half-life membrane protein degraded in lysosomes, negatively controls down-regulation of connexin43.

Ohzono C, Etoh S, Matsumoto M, Nakayama KI, Hirota Y, Tanaka Y, Fujita H.

Biol Pharm Bull. 2010;33(6):951-7.

9.

Eps15 interacts with ubiquitinated Cx43 and mediates its internalization.

Girão H, Catarino S, Pereira P.

Exp Cell Res. 2009 Dec 10;315(20):3587-97. doi: 10.1016/j.yexcr.2009.10.003. Epub 2009 Oct 14.

PMID:
19835873
10.

Norepinephrine inhibits intercellular coupling in rat cardiomyocytes by ubiquitination of connexin43 gap junctions.

Mollerup S, Hofgaard JP, Braunstein TH, Kjenseth A, Leithe E, Rivedal E, Holstein-Rathlou NH, Nielsen MS.

Cell Commun Adhes. 2011 Aug;18(4):57-65. doi: 10.3109/15419061.2011.611920. Epub 2011 Sep 21.

PMID:
21936631
11.

AMSH-mediated deubiquitination of Cx43 regulates internalization and degradation of gap junctions.

Ribeiro-Rodrigues TM, Catarino S, Marques C, Ferreira JV, Martins-Marques T, Pereira P, Girão H.

FASEB J. 2014 Nov;28(11):4629-41. doi: 10.1096/fj.13-248963. Epub 2014 Jul 28.

PMID:
25070368
12.

Association of connexin43 with E3 ubiquitin ligase TRIM21 reveals a mechanism for gap junction phosphodegron control.

Chen VC, Kristensen AR, Foster LJ, Naus CC.

J Proteome Res. 2012 Dec 7;11(12):6134-46. doi: 10.1021/pr300790h. Epub 2012 Nov 8.

PMID:
23106098
13.

Epidermal growth factor regulates ubiquitination, internalization and proteasome-dependent degradation of connexin43.

Leithe E, Rivedal E.

J Cell Sci. 2004 Mar 1;117(Pt 7):1211-20. Epub 2004 Feb 17. Erratum in: J Cell Sci. 2004 Mar 15;117(8):1613.

14.

Regulation of gap junction intercellular communication by the ubiquitin system.

Kjenseth A, Fykerud T, Rivedal E, Leithe E.

Cell Signal. 2010 Sep;22(9):1267-73. doi: 10.1016/j.cellsig.2010.03.005. Epub 2010 Mar 4. Review.

PMID:
20206687
15.

Cardiomyocyte-specific overexpression of the ubiquitin ligase Wwp1 contributes to reduction in Connexin 43 and arrhythmogenesis.

Basheer WA, Harris BS, Mentrup HL, Abreha M, Thames EL, Lea JB, Swing DA, Copeland NG, Jenkins NA, Price RL, Matesic LE.

J Mol Cell Cardiol. 2015 Nov;88:1-13. doi: 10.1016/j.yjmcc.2015.09.004. Epub 2015 Sep 16.

16.

The detergent resistance of Connexin43 is lost upon TPA or EGF treatment and is an early step in gap junction endocytosis.

Sirnes S, Leithe E, Rivedal E.

Biochem Biophys Res Commun. 2008 Sep 5;373(4):597-601. doi: 10.1016/j.bbrc.2008.06.095. Epub 2008 Jul 2.

PMID:
18601906
17.

Endocytic processing of connexin43 gap junctions: a morphological study.

Leithe E, Brech A, Rivedal E.

Biochem J. 2006 Jan 1;393(Pt 1):59-67.

19.

Protein kinase Cδ-mediated phosphorylation of Connexin43 gap junction channels causes movement within gap junctions followed by vesicle internalization and protein degradation.

Cone AC, Cavin G, Ambrosi C, Hakozaki H, Wu-Zhang AX, Kunkel MT, Newton AC, Sosinsky GE.

J Biol Chem. 2014 Mar 28;289(13):8781-98. doi: 10.1074/jbc.M113.533265. Epub 2014 Feb 5.

20.

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