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4-(Nitrophenylsulfonyl)piperazines mitigate radiation damage to multiple tissues.

Micewicz ED, Kim K, Iwamoto KS, Ratikan JA, Cheng G, Boxx GM, Damoiseaux RD, Whitelegge JP, Ruchala P, Nguyen C, Purbey P, Loo J, Deng G, Jung ME, Sayre JW, Norris AJ, Schaue D, McBride WH.

PLoS One. 2017 Jul 21;12(7):e0181577. doi: 10.1371/journal.pone.0181577. eCollection 2017.


The Aftermath of Surviving Acute Radiation Hematopoietic Syndrome and its Mitigation.

Micewicz ED, Iwamoto KS, Ratikan JA, Nguyen C, Xie MW, Cheng G, Boxx GM, Deriu E, Damoiseaux RD, Whitelegge JP, Ruchala PP, Avetisyan R, Jung ME, Lawson G, Nemeth E, Ganz T, Sayre JW, McBride WH, Schaue D.

Radiat Res. 2019 Apr;191(4):323-334. doi: 10.1667/RR15231.1. Epub 2019 Feb 7.


Inhibiting glycogen synthase kinase-3 mitigates the hematopoietic acute radiation syndrome in mice.

Lee CL, Lento WE, Castle KD, Chao NJ, Kirsch DG.

Radiat Res. 2014 May;181(5):445-51. doi: 10.1667/RR13692.1. Epub 2014 Apr 10.


Administration of ON 01210.Na after exposure to ionizing radiation protects bone marrow cells by attenuating DNA damage response.

Suman S, Maniar M, Fornace AJ Jr, Datta K.

Radiat Oncol. 2012 Jan 20;7:6. doi: 10.1186/1748-717X-7-6.


Expansion of CD11b(+)Ly6G (+)Ly6C (int) cells driven by medroxyprogesterone acetate in mice bearing breast tumors restrains NK cell effector functions.

Spallanzani RG, Dalotto-Moreno T, Raffo Iraolagoitia XL, Ziblat A, Domaica CI, Avila DE, Rossi LE, Fuertes MB, Battistone MA, Rabinovich GA, Salatino M, Zwirner NW.

Cancer Immunol Immunother. 2013 Dec;62(12):1781-95. doi: 10.1007/s00262-013-1483-x. Epub 2013 Oct 11.


Bilirubin augments radiation injury and leads to increased infection and mortality in mice: molecular mechanisms.

Khan NM, Poduval TB.

Free Radic Biol Med. 2012 Sep 1;53(5):1152-69. doi: 10.1016/j.freeradbiomed.2012.07.007. Epub 2012 Jul 20.


Compartmental responses after thoracic irradiation of mice: strain differences.

Chiang CS, Liu WC, Jung SM, Chen FH, Wu CR, McBride WH, Lee CC, Hong JH.

Int J Radiat Oncol Biol Phys. 2005 Jul 1;62(3):862-71.


CD11b+ Ly6Chi Ly6G- immature myeloid cells recruited in response to Salmonella enterica serovar Typhimurium infection exhibit protective and immunosuppressive properties.

Tam JW, Kullas AL, Mena P, Bliska JB, van der Velden AW.

Infect Immun. 2014 Jun;82(6):2606-14. doi: 10.1128/IAI.01590-13. Epub 2014 Apr 7.


C/EBPδ deficiency sensitizes mice to ionizing radiation-induced hematopoietic and intestinal injury.

Pawar SA, Shao L, Chang J, Wang W, Pathak R, Zhu X, Wang J, Hendrickson H, Boerma M, Sterneck E, Zhou D, Hauer-Jensen M.

PLoS One. 2014 Apr 18;9(4):e94967. doi: 10.1371/journal.pone.0094967. eCollection 2014.


Combined mitigation of the gastrointestinal and hematopoietic acute radiation syndromes by an LPA2 receptor-specific nonlipid agonist.

Patil R, Szabó E, Fells JI, Balogh A, Lim KG, Fujiwara Y, Norman DD, Lee SC, Balazs L, Thomas F, Patil S, Emmons-Thompson K, Boler A, Strobos J, McCool SW, Yates CR, Stabenow J, Byrne GI, Miller DD, Tigyi GJ.

Chem Biol. 2015 Feb 19;22(2):206-16. doi: 10.1016/j.chembiol.2014.12.009. Epub 2015 Jan 22.


Tumor apoptosis induced by epoxide-containing piperazines, a new class of anti-cancer agents.

Eilon GF, Gu J, Slater LM, Hara K, Jacobs JW.

Cancer Chemother Pharmacol. 2000;45(3):183-91.


Myeloid progenitors: a radiation countermeasure that is effective when initiated days after irradiation.

Singh VK, Christensen J, Fatanmi OO, Gille D, Ducey EJ, Wise SY, Karsunky H, Sedello AK.

Radiat Res. 2012 Jun;177(6):781-91. Epub 2012 May 4.


Dihydroxyselenolane (DHS) supplementation improves survival following whole-body irradiation (WBI) by suppressing tissue-specific inflammatory responses.

Kunwar A, Verma P, Bhilwade HN, Iwaoka M, Priyadarsini KI.

Mutat Res Genet Toxicol Environ Mutagen. 2016 Sep 1;807:33-46. doi: 10.1016/j.mrgentox.2016.07.002. Epub 2016 Jul 22.


The Protective Effects of 5-Methoxytryptamine-α-lipoic Acid on Ionizing Radiation-Induced Hematopoietic Injury.

Li D, Tian Z, Tang W, Zhang J, Lu L, Sun Z, Zhou Z, Fan F.

Int J Mol Sci. 2016 Jun 14;17(6). pii: E935. doi: 10.3390/ijms17060935.


Intravenous basic fibroblast growth factor protects the lung but not mediastinal organs against radiation-induced apoptosis in vivo.

Fuks Z, Alfieri A, Haimovitz-Friedman A, Seddon A, Cordon-Cardo C.

Cancer J Sci Am. 1995 May-Jun;1(1):62-72. Erratum in: Cancer J Sci Am. 1995 Jul-Aug;1(2):113.


Long-term hematopoietic stem cell damage in a murine model of the hematopoietic syndrome of the acute radiation syndrome.

Chua HL, Plett PA, Sampson CH, Joshi M, Tabbey R, Katz BP, MacVittie TJ, Orschell CM.

Health Phys. 2012 Oct;103(4):356-66. doi: 10.1097/HP.0b013e3182666d6f.


Immature myeloid cells induced by a high-fat diet contribute to liver inflammation.

Deng ZB, Liu Y, Liu C, Xiang X, Wang J, Cheng Z, Shah SV, Zhang S, Zhang L, Zhuang X, Michalek S, Grizzle WE, Zhang HG.

Hepatology. 2009 Nov;50(5):1412-20. doi: 10.1002/hep.23148.


Bone marrow stromal cell transplantation mitigates radiation-induced gastrointestinal syndrome in mice.

Saha S, Bhanja P, Kabarriti R, Liu L, Alfieri AA, Guha C.

PLoS One. 2011;6(9):e24072. doi: 10.1371/journal.pone.0024072. Epub 2011 Sep 15.


Mitigation of radiation injury by selective stimulation of the LPA(2) receptor.

Kiss GN, Lee SC, Fells JI, Liu J, Valentine WJ, Fujiwara Y, Thompson KE, Yates CR, Sümegi B, Tigyi G.

Biochim Biophys Acta. 2013 Jan;1831(1):117-25. doi: 10.1016/j.bbalip.2012.08.020.


Blockade of CD47 increases survival of mice exposed to lethal total body irradiation.

Soto-Pantoja DR, Ridnour LA, Wink DA, Roberts DD.

Sci Rep. 2013;3:1038. doi: 10.1038/srep01038. Epub 2013 Jan 8.

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