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Characterization of potent and selective iodonium-class inhibitors of NADPH oxidases.

Lu J, Risbood P, Kane CT Jr, Hossain MT, Anderson L, Hill K, Monks A, Wu Y, Antony S, Juhasz A, Liu H, Jiang G, Harris E, Roy K, Meitzler JL, Konaté M, Doroshow JH.

Biochem Pharmacol. 2017 Nov 1;143:25-38. doi: 10.1016/j.bcp.2017.07.007. Epub 2017 Jul 11.


Antiproliferative mechanisms of action of the flavin dehydrogenase inhibitors diphenylene iodonium and di-2-thienyliodonium based on molecular profiling of the NCI-60 human tumor cell panel.

Doroshow JH, Juhasz A, Ge Y, Holbeck S, Lu J, Antony S, Wu Y, Jiang G, Roy K.

Biochem Pharmacol. 2012 May 1;83(9):1195-207. doi: 10.1016/j.bcp.2012.01.022. Epub 2012 Jan 24.


Effects of iodonium-class flavin dehydrogenase inhibitors on growth, reactive oxygen production, cell cycle progression, NADPH oxidase 1 levels, and gene expression in human colon cancer cells and xenografts.

Doroshow JH, Gaur S, Markel S, Lu J, van Balgooy J, Synold TW, Xi B, Wu X, Juhasz A.

Free Radic Biol Med. 2013 Apr;57:162-75. doi: 10.1016/j.freeradbiomed.2013.01.002. Epub 2013 Jan 11.


Studies on the inhibitory mechanism of iodonium compounds with special reference to neutrophil NADPH oxidase.

O'Donnell BV, Tew DG, Jones OT, England PJ.

Biochem J. 1993 Feb 15;290 ( Pt 1):41-9.


Early NADPH oxidase-2 activation is crucial in phenylephrine-induced hypertrophy of H9c2 cells.

Hahn NE, Musters RJ, Fritz JM, Pagano PJ, Vonk AB, Paulus WJ, van Rossum AC, Meischl C, Niessen HW, Krijnen PA.

Cell Signal. 2014 Sep;26(9):1818-24. doi: 10.1016/j.cellsig.2014.04.018. Epub 2014 May 2.


TGF-beta-induced p38 activation is mediated by Rac1-regulated generation of reactive oxygen species in cultured human keratinocytes.

Chiu C, Maddock DA, Zhang Q, Souza KP, Townsend AR, Wan Y.

Int J Mol Med. 2001 Sep;8(3):251-5.


Role of reactive O2 in phagocyte-induced hypermetabolism and pulmonary injury.

Vlessis AA, Bartos D, Muller P, Trunkey DD.

J Appl Physiol (1985). 1995 Jan;78(1):112-6.


NADPH oxidase plays a crucial role in the activation of pancreatic stellate cells.

Masamune A, Watanabe T, Kikuta K, Satoh K, Shimosegawa T.

Am J Physiol Gastrointest Liver Physiol. 2008 Jan;294(1):G99-G108. Epub 2007 Oct 25.


Comparative pharmacology of chemically distinct NADPH oxidase inhibitors.

Wind S, Beuerlein K, Eucker T, Müller H, Scheurer P, Armitage ME, Ho H, Schmidt HH, Wingler K.

Br J Pharmacol. 2010 Oct;161(4):885-98. doi: 10.1111/j.1476-5381.2010.00920.x.


A Role for Reactive Oxygen Species Produced by NADPH Oxidases in the Embryo and Aleurone Cells in Barley Seed Germination.

Ishibashi Y, Kasa S, Sakamoto M, Aoki N, Kai K, Yuasa T, Hanada A, Yamaguchi S, Iwaya-Inoue M.

PLoS One. 2015 Nov 18;10(11):e0143173. doi: 10.1371/journal.pone.0143173. eCollection 2015.


Diphenylene iodonium interferes with cell cycle progression and induces apoptosis by modulating NAD(P)H oxidase/ROS/cell cycle regulatory pathways in Burkitt's lymphoma cells.

Ding Y, Zhu W, Sun R, Yuan G, Zhang D, Fan Y, Sun J.

Oncol Rep. 2015 Mar;33(3):1434-42. doi: 10.3892/or.2015.3726. Epub 2015 Jan 15.


Effect of atrial natriuretic peptide on reactive oxygen species-induced by hydrogen peroxide in THP-1 monocytes: role in cell growth, migration and cytokine release.

De Vito P, Incerpi S, Affabris E, Percario Z, Borgatti M, Gambari R, Pedersen JZ, Luly P.

Peptides. 2013 Dec;50:100-8. doi: 10.1016/j.peptides.2013.09.002. Epub 2013 Oct 11.


A subset of N-substituted phenothiazines inhibits NADPH oxidases.

Seredenina T, Chiriano G, Filippova A, Nayernia Z, Mahiout Z, Fioraso-Cartier L, Plastre O, Scapozza L, Krause KH, Jaquet V.

Free Radic Biol Med. 2015 Sep;86:239-49. doi: 10.1016/j.freeradbiomed.2015.05.023. Epub 2015 May 23.


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